ID   MAZE_STAES              Reviewed;          56 AA.
AC   Q8CRQ0;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Antitoxin MazE;
GN   Name=mazE; OrderedLocusNames=SE_1673;
OS   Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=176280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 12228 / FDA PCI 1200;
RX   PubMed=12950922; DOI=10.1046/j.1365-2958.2003.03671.x;
RA   Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q.,
RA   Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H.,
RA   Zhao G.-P., Qu D., Danchin A., Wen Y.-M.;
RT   "Genome-based analysis of virulence genes in a non-biofilm-forming
RT   Staphylococcus epidermidis strain (ATCC 12228).";
RL   Mol. Microbiol. 49:1577-1593(2003).
CC   -!- FUNCTION: Antitoxin component of a type II toxin-antitoxin (TA) system.
CC       Labile antitoxin that binds to cognate MazF toxin and counteracts its
CC       endoribonuclease activity. {ECO:0000250|UniProtKB:P0C7B4}.
CC   -!- SUBUNIT: Forms a complex with cognate toxin MazF which inhibits the
CC       endoribonuclease activity of MazF. {ECO:0000250|UniProtKB:P0C7B4}.
CC   -!- SIMILARITY: Belongs to the MazE/EndoAI family. {ECO:0000305}.
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DR   EMBL; AE015929; AAO05272.1; -; Genomic_DNA.
DR   RefSeq; NP_765228.1; NC_004461.1.
DR   RefSeq; WP_001829931.1; NZ_WBME01000071.1.
DR   AlphaFoldDB; Q8CRQ0; -.
DR   SMR; Q8CRQ0; -.
DR   STRING; 176280.SE_1673; -.
DR   EnsemblBacteria; AAO05272; AAO05272; SE_1673.
DR   GeneID; 50018226; -.
DR   KEGG; sep:SE_1673; -.
DR   PATRIC; fig|176280.10.peg.1634; -.
DR   eggNOG; ENOG50305BV; Bacteria.
DR   HOGENOM; CLU_3012108_0_0_9; -.
DR   OMA; AYSVECE; -.
DR   Proteomes; UP000001411; Chromosome.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 1.10.1220.10; -; 1.
DR   InterPro; IPR013321; Arc_rbn_hlx_hlx.
PE   3: Inferred from homology;
KW   Toxin-antitoxin system.
FT   CHAIN           1..56
FT                   /note="Antitoxin MazE"
FT                   /id="PRO_0000330721"
SQ   SEQUENCE   56 AA;  6290 MW;  6EB3005659287A5A CRC64;
     MLSFNQNRNH SLEQSLKEGY AQMADLNLSL ATEAFPIECE ACDCNESHLI SNSKNE