ID   MAZE_STAHJ              Reviewed;          56 AA.
AC   Q4L7V4;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Antitoxin MazE;
GN   Name=mazE; OrderedLocusNames=SH0962;
OS   Staphylococcus haemolyticus (strain JCSC1435).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=279808;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCSC1435;
RX   PubMed=16237012; DOI=10.1128/jb.187.21.7292-7308.2005;
RA   Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y.,
RA   Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C.,
RA   Hiramatsu K.;
RT   "Whole-genome sequencing of Staphylococcus haemolyticus uncovers the
RT   extreme plasticity of its genome and the evolution of human-colonizing
RT   staphylococcal species.";
RL   J. Bacteriol. 187:7292-7308(2005).
CC   -!- FUNCTION: Antitoxin component of a type II toxin-antitoxin (TA) system.
CC       Labile antitoxin that binds to cognate MazF toxin and counteracts its
CC       endoribonuclease activity. {ECO:0000250|UniProtKB:P0C7B4}.
CC   -!- SUBUNIT: Forms a complex with cognate toxin MazF which inhibits the
CC       endoribonuclease activity of MazF. {ECO:0000250|UniProtKB:P0C7B4}.
CC   -!- SIMILARITY: Belongs to the MazE/EndoAI family. {ECO:0000305}.
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DR   EMBL; AP006716; BAE04271.1; -; Genomic_DNA.
DR   RefSeq; WP_011275271.1; NC_007168.1.
DR   AlphaFoldDB; Q4L7V4; -.
DR   SMR; Q4L7V4; -.
DR   STRING; 279808.SH0962; -.
DR   EnsemblBacteria; BAE04271; BAE04271; SH0962.
DR   KEGG; sha:SH0962; -.
DR   eggNOG; ENOG50305BV; Bacteria.
DR   HOGENOM; CLU_3012108_0_0_9; -.
DR   OMA; AYSVECE; -.
DR   OrthoDB; 2014469at2; -.
DR   Proteomes; UP000000543; Chromosome.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 1.10.1220.10; -; 1.
DR   InterPro; IPR013321; Arc_rbn_hlx_hlx.
PE   3: Inferred from homology;
KW   Toxin-antitoxin system.
FT   CHAIN           1..56
FT                   /note="Antitoxin MazE"
FT                   /id="PRO_0000330723"
SQ   SEQUENCE   56 AA;  6380 MW;  B177E26E0F9D2A40 CRC64;
     MLTFNQNRSH SLEQSLKEGY AQMAELNLSL ATEAFPLECE ACDCNETYLI SNYKSE