ID   MAZF1_MYCTU             Reviewed;          93 AA.
AC   Q6MX40; L0T6I7;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Probable endoribonuclease MazF1 {ECO:0000305};
DE            EC=3.1.-.-;
DE   AltName: Full=Probable toxin MazF1;
GN   Name=mazF1; Synonyms=mazF-mt2 {ECO:0000303|PubMed:16611633};
GN   OrderedLocusNames=Rv0456A;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION, AND POSSIBLE FUNCTION.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=15718296; DOI=10.1093/nar/gki201;
RA   Pandey D.P., Gerdes K.;
RT   "Toxin-antitoxin loci are highly abundant in free-living but lost from
RT   host-associated prokaryotes.";
RL   Nucleic Acids Res. 33:966-976(2005).
RN   [3]
RP   GENE NAME, AND POSSIBLE FUNCTION.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=16611633; DOI=10.1074/jbc.m512693200;
RA   Zhu L., Zhang Y., Teh J.S., Zhang J., Connell N., Rubin H., Inouye M.;
RT   "Characterization of mRNA interferases from Mycobacterium tuberculosis.";
RL   J. Biol. Chem. 281:18638-18643(2006).
CC   -!- FUNCTION: Toxic component of a type II toxin-antitoxin (TA) system, its
CC       cognate antitoxin is MazE1 (Probable). Probably an endoribonuclease (By
CC       similarity). {ECO:0000250|UniProtKB:P9WIH9, ECO:0000305}.
CC   -!- SUBUNIT: Forms a complex with cognate antitoxin MazE1.
CC       {ECO:0000250|UniProtKB:P9WIH9}.
CC   -!- SIMILARITY: Belongs to the PemK/MazF family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP43188.1; -; Genomic_DNA.
DR   RefSeq; WP_003402288.1; NC_000962.3.
DR   RefSeq; YP_177621.1; NC_000962.3.
DR   AlphaFoldDB; Q6MX40; -.
DR   SMR; Q6MX40; -.
DR   STRING; 83332.Rv0456A; -.
DR   PaxDb; Q6MX40; -.
DR   GeneID; 3205039; -.
DR   KEGG; mtu:Rv0456A; -.
DR   TubercuList; Rv0456A; -.
DR   eggNOG; COG2337; Bacteria.
DR   InParanoid; Q6MX40; -.
DR   PhylomeDB; Q6MX40; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0004521; F:endoribonuclease activity; IBA:GO_Central.
DR   GO; GO:0006402; P:mRNA catabolic process; IBA:GO_Central.
DR   GO; GO:0016075; P:rRNA catabolic process; IBA:GO_Central.
DR   Gene3D; 2.30.30.110; -; 1.
DR   InterPro; IPR003477; PemK-like.
DR   InterPro; IPR011067; Plasmid_toxin/cell-grow_inhib.
DR   PANTHER; PTHR33988; PTHR33988; 1.
DR   Pfam; PF02452; PemK_toxin; 1.
PE   3: Inferred from homology;
KW   Endonuclease; Hydrolase; Nuclease; Reference proteome;
KW   Toxin-antitoxin system.
FT   CHAIN           1..93
FT                   /note="Probable endoribonuclease MazF1"
FT                   /id="PRO_0000406304"
SQ   SEQUENCE   93 AA;  9925 MW;  ED1BFC5F6A84DC92 CRC64;
     MLRGEIWQVD LDPARGSAAN MRRPAVIVSN DRANAAAIRL DRGVVPVVPV TSNTEKVPIP
     GVVAGSERWP GRRFEGAGPA GWIRRCATSP LPS