ID   MAZF2_MYCTO             Reviewed;         102 AA.
AC   P9WII0; L0T7C6; O06780; Q7D9G9;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 35.
DE   RecName: Full=Probable endoribonuclease MazF2;
DE            EC=3.1.-.-;
DE   AltName: Full=Probable toxin MazF2;
GN   Name=mazF2; OrderedLocusNames=MT0688;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Toxic component of a type II toxin-antitoxin (TA) system.
CC       Acts as an endoribonuclease. Neutralized by coexpression with cognate
CC       antitoxin MazE2. {ECO:0000250|UniProtKB:P9WII1}.
CC   -!- SUBUNIT: Forms a complex with cognate antitoxin MazE2.
CC       {ECO:0000250|UniProtKB:P9WII1}.
CC   -!- SIMILARITY: Belongs to the PemK/MazF family. {ECO:0000305}.
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DR   EMBL; AE000516; AAK44913.1; -; Genomic_DNA.
DR   PIR; F70534; F70534.
DR   RefSeq; WP_003403376.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WII0; -.
DR   SMR; P9WII0; -.
DR   EnsemblBacteria; AAK44913; AAK44913; MT0688.
DR   KEGG; mtc:MT0688; -.
DR   PATRIC; fig|83331.31.peg.732; -.
DR   HOGENOM; CLU_174647_1_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.30.30.110; -; 1.
DR   InterPro; IPR003477; PemK-like.
DR   InterPro; IPR011067; Plasmid_toxin/cell-grow_inhib.
DR   PANTHER; PTHR33988; PTHR33988; 1.
DR   Pfam; PF02452; PemK_toxin; 1.
PE   3: Inferred from homology;
KW   Endonuclease; Hydrolase; Nuclease; Toxin-antitoxin system.
FT   CHAIN           1..102
FT                   /note="Probable endoribonuclease MazF2"
FT                   /id="PRO_0000428003"
SQ   SEQUENCE   102 AA;  11320 MW;  6EB2F795CAAE1E11 CRC64;
     MRRGELWFAA TPGGDRPVLV LTRDPVADRI GAVVVVALTR TRRGLVSELE LTAVENRVPS
     DCVVNFDNIH TLPRTAFRRR ITRLSPARLH EACQTLRAST GC