ID   MAZF3_MYCTO             Reviewed;         103 AA.
AC   P9WIH8; L0T5Q4; O53450; Q7D8U7;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 37.
DE   RecName: Full=Endoribonuclease MazF3 {ECO:0000305};
DE            EC=3.1.-.-;
DE   AltName: Full=Toxin MazF3;
DE   AltName: Full=mRNA interferase MazF3;
GN   Name=mazF3; OrderedLocusNames=MT1134;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Toxic component of a type II toxin-antitoxin (TA) system.
CC       Acts as an endoribonuclease, cleaving in U-rich regions. Neutralized by
CC       cognate antitoxin MazE3. {ECO:0000250|UniProtKB:P9WIH9}.
CC   -!- SUBUNIT: Forms a complex with cognate antitoxin MazE3.
CC       {ECO:0000250|UniProtKB:P9WIH9}.
CC   -!- SIMILARITY: Belongs to the PemK/MazF family. {ECO:0000305}.
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DR   EMBL; AE000516; AAK45392.1; -; Genomic_DNA.
DR   PIR; D70897; D70897.
DR   RefSeq; WP_003898728.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WIH8; -.
DR   SMR; P9WIH8; -.
DR   EnsemblBacteria; AAK45392; AAK45392; MT1134.
DR   KEGG; mtc:MT1134; -.
DR   PATRIC; fig|83331.31.peg.1224; -.
DR   HOGENOM; CLU_174647_0_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.30.30.110; -; 1.
DR   InterPro; IPR003477; PemK-like.
DR   InterPro; IPR011067; Plasmid_toxin/cell-grow_inhib.
DR   PANTHER; PTHR33988; PTHR33988; 1.
DR   Pfam; PF02452; PemK_toxin; 1.
PE   3: Inferred from homology;
KW   Endonuclease; Hydrolase; Nuclease; Toxin-antitoxin system.
FT   CHAIN           1..103
FT                   /note="Endoribonuclease MazF3"
FT                   /id="PRO_0000428004"
SQ   SEQUENCE   103 AA;  11050 MW;  5785AF38C1C1E19D CRC64;
     MRPIHIAQLD KARPVLILTR EVVRPHLTNV TVAPITTTVR GLATEVPVDA VNGLNQPSVV
     SCDNTQTIPV CDLGRQIGYL LASQEPALAE AIGNAFDLDW VVA