ID   MAZF6_MYCTO             Reviewed;         114 AA.
AC   P9WII2; L0T8B0; P64911; Q10867;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 35.
DE   RecName: Full=Endoribonuclease MazF6 {ECO:0000305};
DE            EC=3.1.27.- {ECO:0000305};
DE   AltName: Full=Toxin MazF6;
DE   AltName: Full=mRNA interferase MazF6;
GN   Name=mazF6; OrderedLocusNames=MT2046;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Toxic component of a type II toxin-antitoxin (TA) system.
CC       Acts as an endoribonuclease on single-strand RNA, cleaving between the
CC       second and third bases in the sequences CUCCU and UUCCU. Neutralized by
CC       coexpression with cognate antitoxin MazE6.
CC       {ECO:0000250|UniProtKB:P9WII3}.
CC   -!- SUBUNIT: Forms a complex with cognate toxin MazE6, which neutralizes
CC       the toxin. {ECO:0000250|UniProtKB:P9WII3}.
CC   -!- SIMILARITY: Belongs to the PemK/MazF family. {ECO:0000305}.
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DR   EMBL; AE000516; AAK46323.1; -; Genomic_DNA.
DR   PIR; E70757; E70757.
DR   RefSeq; WP_003410010.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WII2; -.
DR   SMR; P9WII2; -.
DR   EnsemblBacteria; AAK46323; AAK46323; MT2046.
DR   GeneID; 45425969; -.
DR   KEGG; mtc:MT2046; -.
DR   HOGENOM; CLU_121823_1_1_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.30.30.110; -; 1.
DR   InterPro; IPR003477; PemK-like.
DR   InterPro; IPR011067; Plasmid_toxin/cell-grow_inhib.
DR   PANTHER; PTHR33988; PTHR33988; 1.
DR   Pfam; PF02452; PemK_toxin; 1.
DR   PIRSF; PIRSF033490; MazF; 1.
PE   3: Inferred from homology;
KW   Endonuclease; Hydrolase; Nuclease; Toxin-antitoxin system.
FT   CHAIN           1..114
FT                   /note="Endoribonuclease MazF6"
FT                   /id="PRO_0000428002"
SQ   SEQUENCE   114 AA;  12262 MW;  59A18C54B9EDDBCE CRC64;
     MVISRAEIYW ADLGPPSGSQ PAKRRPVLVI QSDPYNASRL ATVIAAVITS NTALAAMPGN
     VFLPATTTRL PRDSVVNVTA IVTLNKTDLT DRVGEVPASL MHEVDRGLRR VLDL