ID   MAZF8_MYCTO             Reviewed;         105 AA.
AC   P9WIH6; L0T9C1; Q50689;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 19.
DE   RecName: Full=Putative toxin MazF8;
DE            EC=3.1.-.-;
GN   Name=mazF8; OrderedLocusNames=MT2334.2;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Putative toxic component of a type II toxin-antitoxin (TA)
CC       system. Acts as an endoribonuclease. Neutralized by coexpression with
CC       cognate antitoxin MazE8. {ECO:0000250|UniProtKB:P9WIH7, ECO:0000305}.
CC   -!- SUBUNIT: Forms a complex with cognate antitoxin MazE8.
CC       {ECO:0000250|UniProtKB:P9WIH7}.
CC   -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR   EMBL; AE000516; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PIR; F70730; F70730.
DR   RefSeq; WP_003903830.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WIH6; -.
DR   GeneID; 45426256; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
PE   5: Uncertain;
KW   Endonuclease; Hydrolase; Nuclease; Toxin-antitoxin system.
FT   CHAIN           1..105
FT                   /note="Putative toxin MazF8"
FT                   /id="PRO_0000428005"
SQ   SEQUENCE   105 AA;  11046 MW;  BBB3716AA9ADDE26 CRC64;
     MSIARSAQPI GWISCPPKGG SSCCRCGGGY THIFCVSAWT GLVVDLQAEQ VRSVVTERLR
     RRIGRGAPIL AGTLAPGVGL AAQNREFRQF TGRSAPPSAT IAFGE