ID   MAZF8_MYCTU             Reviewed;         105 AA.
AC   P9WIH7; L0T9C1; Q50689;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 31.
DE   RecName: Full=Putative toxin MazF8 {ECO:0000305};
DE            EC=3.1.-.-;
GN   Name=mazF8; OrderedLocusNames=Rv2274c; ORFNames=MTCY339.36;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
CC   -!- FUNCTION: Putative toxic component of a type II toxin-antitoxin (TA)
CC       system, its cognate toxin is MaZE8. Probably an endoribonuclease (By
CC       similarity). {ECO:0000250|UniProtKB:P9WIH9, ECO:0000305}.
CC   -!- SUBUNIT: Forms a complex with cognate antitoxin MazE8.
CC       {ECO:0000250|UniProtKB:P9WIH9}.
CC   -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR   EMBL; AL123456; CCP45055.1; -; Genomic_DNA.
DR   PIR; F70730; F70730.
DR   RefSeq; NP_216790.1; NC_000962.3.
DR   RefSeq; WP_003903830.1; NZ_NVQJ01000008.1.
DR   AlphaFoldDB; P9WIH7; -.
DR   STRING; 83332.Rv2274c; -.
DR   PaxDb; P9WIH7; -.
DR   DNASU; 888067; -.
DR   GeneID; 45426256; -.
DR   GeneID; 888067; -.
DR   KEGG; mtu:Rv2274c; -.
DR   TubercuList; Rv2274c; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
PE   5: Uncertain;
KW   Endonuclease; Hydrolase; Nuclease; Reference proteome;
KW   Toxin-antitoxin system.
FT   CHAIN           1..105
FT                   /note="Putative toxin MazF8"
FT                   /id="PRO_0000104003"
SQ   SEQUENCE   105 AA;  11046 MW;  BBB3716AA9ADDE26 CRC64;
     MSIARSAQPI GWISCPPKGG SSCCRCGGGY THIFCVSAWT GLVVDLQAEQ VRSVVTERLR
     RRIGRGAPIL AGTLAPGVGL AAQNREFRQF TGRSAPPSAT IAFGE