MAZF_STAA3
ID MAZF_STAA3 Reviewed; 120 AA.
AC Q2FF56;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2006, sequence version 1.
DT 25-MAY-2022, entry version 83.
DE RecName: Full=Endoribonuclease MazF;
DE EC=3.1.-.-;
DE AltName: Full=Toxin MazF;
DE AltName: Full=mRNA interferase MazF;
GN Name=mazF; OrderedLocusNames=SAUSA300_2026;
OS Staphylococcus aureus (strain USA300).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=367830;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=USA300;
RX PubMed=16517273; DOI=10.1016/s0140-6736(06)68231-7;
RA Diep B.A., Gill S.R., Chang R.F., Phan T.H., Chen J.H., Davidson M.G.,
RA Lin F., Lin J., Carleton H.A., Mongodin E.F., Sensabaugh G.F.,
RA Perdreau-Remington F.;
RT "Complete genome sequence of USA300, an epidemic clone of community-
RT acquired meticillin-resistant Staphylococcus aureus.";
RL Lancet 367:731-739(2006).
CC -!- FUNCTION: Toxic component of a type II toxin-antitoxin (TA) system.
CC Ribosome-independent, sequence-specific endoribonuclease that cleaves
CC mRNA, thus inhibiting protein synthesis and inducing bacterial stasis.
CC It cuts between the first and nucleotides of 5'-UACAU-3' in single-
CC stranded RNA. Neutralized by coexpression with cognate antitoxin MazE.
CC {ECO:0000250|UniProtKB:A6QIR4}.
CC -!- SUBUNIT: Forms a complex with MazE which is no longer active as an
CC endoribonuclease. {ECO:0000250|UniProtKB:A6QIR4}.
CC -!- SIMILARITY: Belongs to the PemK/MazF family. {ECO:0000305}.
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DR EMBL; CP000255; ABD22408.1; -; Genomic_DNA.
DR RefSeq; WP_000621175.1; NZ_CP027476.1.
DR AlphaFoldDB; Q2FF56; -.
DR BMRB; Q2FF56; -.
DR SMR; Q2FF56; -.
DR EnsemblBacteria; ABD22408; ABD22408; SAUSA300_2026.
DR KEGG; saa:SAUSA300_2026; -.
DR HOGENOM; CLU_121823_1_0_9; -.
DR OMA; NDIGNQY; -.
DR Proteomes; UP000001939; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR Gene3D; 2.30.30.110; -; 1.
DR InterPro; IPR003477; PemK-like.
DR InterPro; IPR011067; Plasmid_toxin/cell-grow_inhib.
DR PANTHER; PTHR33988; PTHR33988; 1.
DR Pfam; PF02452; PemK_toxin; 1.
DR PIRSF; PIRSF033490; MazF; 1.
PE 3: Inferred from homology;
KW Endonuclease; Hydrolase; Nuclease; RNA-binding; Toxin-antitoxin system.
FT CHAIN 1..120
FT /note="Endoribonuclease MazF"
FT /id="PRO_0000330704"
SQ SEQUENCE 120 AA; 13442 MW; 41D531536BAE2B57 CRC64;
MIRRGDVYLA DLSPVQGSEQ GGVRPVVIIQ NDTGNKYSPT VIVAAITGRI NKAKIPTHVE
IEKKKYKLDK DSVILLEQIR TLDKKRLKEK LTYLSDDKMK EVDNALMISL GLNAVAHQKN