ID   MAZ_MESAU               Reviewed;         331 AA.
AC   P56670;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1999, sequence version 1.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=Myc-associated zinc finger protein;
DE            Short=MAZI;
DE   AltName: Full=Pur-1;
DE   AltName: Full=Purine-binding transcription factor;
DE   Flags: Fragment;
GN   Name=MAZ;
OS   Mesocricetus auratus (Golden hamster).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Mesocricetus.
OX   NCBI_TaxID=10036;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RC   TISSUE=Pancreas;
RX   PubMed=1454839; DOI=10.1073/pnas.89.23.11498;
RA   Kennedy G.C., Rutter W.J.;
RT   "Pur-1, a zinc-finger protein which binds to purine-rich sequences,
RT   activates an insulin promoter in heterologous cells.";
RL   Proc. Natl. Acad. Sci. U.S.A. 89:11498-11502(1992).
CC   -!- FUNCTION: Transcriptional regulator (By similarity). Acts as a
CC       transcriptional activator that binds to purine-rich GAGA sites found in
CC       the promoter of many genes including insulin I and II and islet amyloid
CC       polypeptide (PubMed:1454839). {ECO:0000250|UniProtKB:P56270,
CC       ECO:0000269|PubMed:1454839}.
CC   -!- SUBUNIT: Interacts with BPTF. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- TISSUE SPECIFICITY: Ubiquitously expressed.
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DR   EMBL; L06008; -; NOT_ANNOTATED_CDS; mRNA.
DR   PIR; B47236; B47236.
DR   AlphaFoldDB; P56670; -.
DR   STRING; 10036.XP_005064433.1; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   Proteomes; UP000189706; Unplaced.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:MGI.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF00096; zf-C2H2; 1.
DR   SMART; SM00355; ZnF_C2H2; 3.
DR   SUPFAM; SSF57667; SSF57667; 2.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           <1..>331
FT                   /note="Myc-associated zinc finger protein"
FT                   /id="PRO_0000047216"
FT   ZN_FING         177..199
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         266..288
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         294..316
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         324..>331
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          46..65
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          108..131
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        115..131
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT   NON_TER         331
SQ   SEQUENCE   331 AA;  33374 MW;  0482F1AF43264B32 CRC64;
     FPVLGLDSRG VGGLMNSFPP PQGHAQNPLQ VGAELQSRFF ASQGCAQSPF QAAPAPPPTP
     QAPAAEPLQV DLLPVLAAAQ ESAAAAAAAA AAAAAVVTAP PAPAAASTVD TAALKQPPAP
     PPPPPAVSAP AAEAAPPAAA ATIAAAAATA VVAPTSTVAV APVASVLEKK TKSKGPYICA
     LCAKEFKNGY NLRRHEAIHT GAKAGRVPSG AMKMPTMVPL SLLSVPQLSG ASGGGGEAGA
     GGGTTAVAAG GVVTTTASGK RIRKNHACEM CGKAFRDVYH LNRHKLSHSD EKPYQCPVCQ
     QRFKRKDRMS YHVRSHDGAV HKPYNCSHCG K