ID   MB12A_CHICK             Reviewed;         267 AA.
AC   Q5ZJX7;
DT   05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Multivesicular body subunit 12A;
DE   AltName: Full=ESCRT-I complex subunit MVB12A;
DE   AltName: Full=Protein FAM125A;
GN   Name=MVB12A; Synonyms=FAM125A; ORFNames=RCJMB04_14j17;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Component of the ESCRT-I complex, a regulator of vesicular
CC       trafficking process. Required for the sorting of endocytic
CC       ubiquitinated cargos into multivesicular bodies (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the ESCRT-I complex (endosomal sorting complex
CC       required for transport I). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Endosome {ECO:0000250}.
CC       Late endosome membrane {ECO:0000250}; Peripheral membrane protein
CC       {ECO:0000250}. Note=Colocalizes with F-actin. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MVB12 family. {ECO:0000305}.
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DR   EMBL; AJ720307; CAG31966.1; -; mRNA.
DR   RefSeq; NP_001026526.1; NM_001031355.1.
DR   AlphaFoldDB; Q5ZJX7; -.
DR   SMR; Q5ZJX7; -.
DR   STRING; 9031.ENSGALP00000029145; -.
DR   PaxDb; Q5ZJX7; -.
DR   GeneID; 426089; -.
DR   KEGG; gga:426089; -.
DR   CTD; 93343; -.
DR   VEuPathDB; HostDB:geneid_426089; -.
DR   eggNOG; KOG4000; Eukaryota.
DR   InParanoid; Q5ZJX7; -.
DR   OrthoDB; 1021387at2759; -.
DR   PhylomeDB; Q5ZJX7; -.
DR   PRO; PR:Q5ZJX7; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0000813; C:ESCRT I complex; IBA:GO_Central.
DR   GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
DR   GO; GO:0032510; P:endosome to lysosome transport via multivesicular body sorting pathway; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0032801; P:receptor catabolic process; IBA:GO_Central.
DR   GO; GO:0042058; P:regulation of epidermal growth factor receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0046755; P:viral budding; IBA:GO_Central.
DR   GO; GO:0019075; P:virus maturation; IBA:GO_Central.
DR   InterPro; IPR023341; MABP.
DR   InterPro; IPR040335; MVB12A.
DR   InterPro; IPR018798; MVB12A/B.
DR   InterPro; IPR023340; UMA.
DR   PANTHER; PTHR31612; PTHR31612; 1.
DR   Pfam; PF10240; DUF2464; 1.
DR   PROSITE; PS51498; MABP; 1.
DR   PROSITE; PS51497; UMA; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Endosome; Membrane; Protein transport; Reference proteome;
KW   SH3-binding; Transport.
FT   CHAIN           1..267
FT                   /note="Multivesicular body subunit 12A"
FT                   /id="PRO_0000249072"
FT   DOMAIN          7..146
FT                   /note="MABP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00831"
FT   DOMAIN          210..259
FT                   /note="UMA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00830"
FT   MOTIF           154..159
FT                   /note="SH3-binding"
SQ   SEQUENCE   267 AA;  28063 MW;  731634B8474E626B CRC64;
     MAAEEEAAPL SGVGWAAGPE SAPAGWSVIT ISVEGSAANL GKGFGHKGGY LCVSTAAPGS
     AGPVVTDVQV LSDRNPQPAG YSRAPEFPEP RSGVSRKKRL YVRLQPRGAA ETAVFDIKLS
     GKSRAVPQYM KIGEIGSFAI WCKKGALPQC SPPPVPKPRT VSLGLKQLSL ADSEQQAPGK
     PVAQSGSRHA SFTLHNSADD GSSIYNLSAM DGVPFTLHPK FERSPKSDSS AILTDLTVKS
     LADIEKEYNY TFVVERTAAA RLPPSIC