ID   MB12A_DANRE             Reviewed;         275 AA.
AC   Q7SXX7;
DT   19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Multivesicular body subunit 12A;
DE   AltName: Full=ESCRT-I complex subunit MVB12A;
DE   AltName: Full=Protein FAM125A;
GN   Name=mvb12a; Synonyms=fam125a; ORFNames=zgc:63691;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=SJD;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the ESCRT-I complex, a regulator of vesicular
CC       trafficking process. Required for the sorting of endocytic
CC       ubiquitinated cargos into multivesicular bodies (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the ESCRT-I complex (endosomal sorting complex
CC       required for transport I).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Endosome {ECO:0000250}.
CC       Late endosome membrane {ECO:0000250}; Peripheral membrane protein
CC       {ECO:0000250}. Note=Colocalizes with F-actin. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MVB12 family. {ECO:0000305}.
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DR   EMBL; BC055206; AAH55206.1; -; mRNA.
DR   RefSeq; NP_956778.1; NM_200484.1.
DR   AlphaFoldDB; Q7SXX7; -.
DR   SMR; Q7SXX7; -.
DR   STRING; 7955.ENSDARP00000062421; -.
DR   PRIDE; Q7SXX7; -.
DR   GeneID; 393456; -.
DR   KEGG; dre:393456; -.
DR   CTD; 93343; -.
DR   ZFIN; ZDB-GENE-040426-1240; mvb12a.
DR   eggNOG; KOG4000; Eukaryota.
DR   InParanoid; Q7SXX7; -.
DR   OrthoDB; 1021387at2759; -.
DR   PhylomeDB; Q7SXX7; -.
DR   Reactome; R-DRE-917729; Endosomal Sorting Complex Required For Transport (ESCRT).
DR   PRO; PR:Q7SXX7; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0000813; C:ESCRT I complex; IBA:GO_Central.
DR   GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
DR   GO; GO:0032510; P:endosome to lysosome transport via multivesicular body sorting pathway; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0032801; P:receptor catabolic process; IBA:GO_Central.
DR   GO; GO:0042058; P:regulation of epidermal growth factor receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0046755; P:viral budding; IBA:GO_Central.
DR   GO; GO:0019075; P:virus maturation; IBA:GO_Central.
DR   InterPro; IPR023341; MABP.
DR   InterPro; IPR040335; MVB12A.
DR   InterPro; IPR018798; MVB12A/B.
DR   InterPro; IPR023340; UMA.
DR   PANTHER; PTHR31612; PTHR31612; 1.
DR   Pfam; PF10240; DUF2464; 1.
DR   PROSITE; PS51498; MABP; 1.
DR   PROSITE; PS51497; UMA; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Endosome; Membrane; Protein transport; Reference proteome;
KW   SH3-binding; Transport.
FT   CHAIN           1..275
FT                   /note="Multivesicular body subunit 12A"
FT                   /id="PRO_0000250374"
FT   DOMAIN          8..146
FT                   /note="MABP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00831"
FT   DOMAIN          215..266
FT                   /note="UMA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00830"
FT   REGION          170..200
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           152..157
FT                   /note="SH3-binding"
FT   COMPBIAS        172..186
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   275 AA;  29766 MW;  05681FE940B3F0CE CRC64;
     MSVCDSSIRP VSAMAWASNT STCPGHFTLI SQTEDGASAN FSRGFVRSGY FLCYSKDLSG
     GMVVADVQVI TDKGTILHGY CYIPEYLEQK ASVAKKKRVC VRLVPVGSVT TAVLDLKLTT
     KHKSMVQQYT CLGDMNGFVV WCLKGPFSPP APQAKPRRVS LDIRSLSLDG PAPPQPLKPS
     NPPEAPPKVS RRRSKLDLPA GGVCDSSVCS GISAMDGVPF TLHPKFESRS SSTKVSVITL
     SDIRIKSVQD IENEYNYTFT VEELAAKRIR PSLSG