ID   MB211_BOVIN             Reviewed;         359 AA.
AC   A4FV14;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   17-APR-2007, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Putative nucleotidyltransferase MAB21L1;
DE            EC=2.7.7.- {ECO:0000305};
DE   AltName: Full=Protein mab-21-like 1;
GN   Name=MAB21L1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal cerebellum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Putative nucleotidyltransferase required for several aspects
CC       of embryonic development including normal development of the eye (By
CC       similarity). It is unclear whether it displays nucleotidyltransferase
CC       activity in vivo. Binds single-stranded RNA (ssRNA) (By similarity).
CC       {ECO:0000250|UniProtKB:O70299, ECO:0000250|UniProtKB:Q13394}.
CC   -!- SUBUNIT: Monomer. Homodecamer; composed of 2 back to back
CC       homopentamers. The protein may exist as monomer in solution and
CC       oiligomerizes upon ligand binding. {ECO:0000250|UniProtKB:Q13394}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O70299}.
CC   -!- SIMILARITY: Belongs to the mab-21 family. {ECO:0000305}.
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DR   EMBL; BC123603; AAI23604.1; -; mRNA.
DR   RefSeq; NP_001091579.1; NM_001098110.2.
DR   AlphaFoldDB; A4FV14; -.
DR   SMR; A4FV14; -.
DR   STRING; 9913.ENSBTAP00000016355; -.
DR   PaxDb; A4FV14; -.
DR   PRIDE; A4FV14; -.
DR   Ensembl; ENSBTAT00000016355; ENSBTAP00000016355; ENSBTAG00000034069.
DR   GeneID; 540081; -.
DR   KEGG; bta:540081; -.
DR   CTD; 4081; -.
DR   VEuPathDB; HostDB:ENSBTAG00000034069; -.
DR   VGNC; VGNC:31127; MAB21L1.
DR   eggNOG; KOG3963; Eukaryota.
DR   GeneTree; ENSGT01050000244827; -.
DR   HOGENOM; CLU_045315_0_0_1; -.
DR   InParanoid; A4FV14; -.
DR   OMA; AVDKCKY; -.
DR   OrthoDB; 771781at2759; -.
DR   TreeFam; TF315012; -.
DR   Proteomes; UP000009136; Chromosome 12.
DR   Bgee; ENSBTAG00000034069; Expressed in retina and 63 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0016779; F:nucleotidyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0001654; P:eye development; ISS:UniProtKB.
DR   InterPro; IPR024810; Mab-21_dom.
DR   Pfam; PF03281; Mab-21; 1.
DR   SMART; SM01265; Mab-21; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Magnesium; Metal-binding; Nucleotide-binding;
KW   Nucleotidyltransferase; Nucleus; Reference proteome; Transferase.
FT   CHAIN           1..359
FT                   /note="Putative nucleotidyltransferase MAB21L1"
FT                   /id="PRO_0000312780"
FT   BINDING         23..24
FT                   /ligand="a ribonucleoside 5'-triphosphate"
FT                   /ligand_id="ChEBI:CHEBI:61557"
FT                   /evidence="ECO:0000250|UniProtKB:Q13394"
FT   BINDING         63..66
FT                   /ligand="a ribonucleoside 5'-triphosphate"
FT                   /ligand_id="ChEBI:CHEBI:61557"
FT                   /evidence="ECO:0000250|UniProtKB:Q13394"
FT   BINDING         73
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000250|UniProtKB:Q8N884"
FT   BINDING         75
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000250|UniProtKB:Q8N884"
FT   BINDING         248
FT                   /ligand="a ribonucleoside 5'-triphosphate"
FT                   /ligand_id="ChEBI:CHEBI:61557"
FT                   /evidence="ECO:0000250|UniProtKB:Q13394"
FT   BINDING         252..255
FT                   /ligand="a ribonucleoside 5'-triphosphate"
FT                   /ligand_id="ChEBI:CHEBI:61557"
FT                   /evidence="ECO:0000250|UniProtKB:Q13394"
SQ   SEQUENCE   359 AA;  40956 MW;  A27C53FBC997A049 CRC64;
     MIAAQAKLVY HLNKYYNEKC QARKAAIAKT IREVCKVVSD VLKEVEVQEP RFISSLNEMD
     NRYEGLEVIS PTEFEVVLYL NQMGVFNFVD DGSLPGCAVL KLSDGRKRSM SLWVEFITAS
     GYLSARKIRS RFQTLVAQAV DKCSYRDVVK MVADTSEVKL RIRDRYVVQI TPAFKCTGIW
     PRSAAHWPLP HIPWPGPNRV AEVKAEGFNL LSKECHSLAG KQSSAESDAW VLQFAEAENR
     LQMGGCRKKC LSILKTLRDR HLELPGQPLN NYHMKTLVSY ECEKHPRESD WDESCLGDRL
     NGILLQLISC LQCRRCPHYF LPNLDLFQGK PHSALENAAK QTWRLAREIL TNPKSLEKL