ID   MB211_CHICK             Reviewed;         359 AA.
AC   Q8AY65;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Putative nucleotidyltransferase MAB21L1;
DE            EC=2.7.7.- {ECO:0000305};
DE   AltName: Full=Protein mab-21-like 1;
GN   Name=MAB21L1;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Wong R.L.Y., Chow K.L.;
RT   "Developmental expression of chicken MAB21 genes.";
RL   Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Putative nucleotidyltransferase required for several aspects
CC       of embryonic development including normal development of the eye (By
CC       similarity). It is unclear whether it displays nucleotidyltransferase
CC       activity in vivo. Binds single-stranded RNA (ssRNA) (By similarity).
CC       {ECO:0000250|UniProtKB:O70299, ECO:0000250|UniProtKB:Q13394}.
CC   -!- SUBUNIT: Monomer. Homodecamer; composed of 2 back to back
CC       homopentamers. The protein may exist as monomer in solution and
CC       oiligomerizes upon ligand binding. {ECO:0000250|UniProtKB:Q13394}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O70299}.
CC   -!- SIMILARITY: Belongs to the mab-21 family. {ECO:0000305}.
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DR   EMBL; AY049705; AAL17977.1; -; mRNA.
DR   RefSeq; NP_989864.1; NM_204533.1.
DR   AlphaFoldDB; Q8AY65; -.
DR   SMR; Q8AY65; -.
DR   STRING; 9031.ENSGALP00000027507; -.
DR   PaxDb; Q8AY65; -.
DR   Ensembl; ENSGALT00000090221; ENSGALP00000059018; ENSGALG00000045052.
DR   GeneID; 395208; -.
DR   KEGG; gga:395208; -.
DR   CTD; 4081; -.
DR   VEuPathDB; HostDB:geneid_395208; -.
DR   eggNOG; KOG3963; Eukaryota.
DR   GeneTree; ENSGT01050000244827; -.
DR   HOGENOM; CLU_045315_0_0_1; -.
DR   InParanoid; Q8AY65; -.
DR   OMA; AVDKCKY; -.
DR   OrthoDB; 771781at2759; -.
DR   PhylomeDB; Q8AY65; -.
DR   PRO; PR:Q8AY65; -.
DR   Proteomes; UP000000539; Chromosome 1.
DR   Bgee; ENSGALG00000045052; Expressed in cerebellum and 2 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0016779; F:nucleotidyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0043010; P:camera-type eye development; IEA:Ensembl.
DR   GO; GO:0008283; P:cell population proliferation; IEA:Ensembl.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
DR   InterPro; IPR024810; Mab-21_dom.
DR   Pfam; PF03281; Mab-21; 1.
DR   SMART; SM01265; Mab-21; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Magnesium; Metal-binding; Nucleotide-binding;
KW   Nucleotidyltransferase; Nucleus; Reference proteome; Transferase.
FT   CHAIN           1..359
FT                   /note="Putative nucleotidyltransferase MAB21L1"
FT                   /id="PRO_0000312783"
FT   BINDING         23..24
FT                   /ligand="a ribonucleoside 5'-triphosphate"
FT                   /ligand_id="ChEBI:CHEBI:61557"
FT                   /evidence="ECO:0000250|UniProtKB:Q13394"
FT   BINDING         63..66
FT                   /ligand="a ribonucleoside 5'-triphosphate"
FT                   /ligand_id="ChEBI:CHEBI:61557"
FT                   /evidence="ECO:0000250|UniProtKB:Q13394"
FT   BINDING         73
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000250|UniProtKB:Q8N884"
FT   BINDING         75
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000250|UniProtKB:Q8N884"
FT   BINDING         248
FT                   /ligand="a ribonucleoside 5'-triphosphate"
FT                   /ligand_id="ChEBI:CHEBI:61557"
FT                   /evidence="ECO:0000250|UniProtKB:Q13394"
FT   BINDING         252..255
FT                   /ligand="a ribonucleoside 5'-triphosphate"
FT                   /ligand_id="ChEBI:CHEBI:61557"
FT                   /evidence="ECO:0000250|UniProtKB:Q13394"
SQ   SEQUENCE   359 AA;  40956 MW;  A27C53FBC997A049 CRC64;
     MIAAQAKLVY HLNKYYNEKC QARKAAIAKT IREVCKVVSD VLKEVEVQEP RFISSLNEMD
     NRYEGLEVIS PTEFEVVLYL NQMGVFNFVD DGSLPGCAVL KLSDGRKRSM SLWVEFITAS
     GYLSARKIRS RFQTLVAQAV DKCSYRDVVK MVADTSEVKL RIRDRYVVQI TPAFKCTGIW
     PRSAAHWPLP HIPWPGPNRV AEVKAEGFNL LSKECHSLAG KQSSAESDAW VLQFAEAENR
     LQMGGCRKKC LSILKTLRDR HLELPGQPLN NYHMKTLVSY ECEKHPRESD WDESCLGDRL
     NGILLQLISC LQCRRCPHYF LPNLDLFQGK PHSALENAAK QTWRLAREIL TNPKSLEKL