ID   MB211_XENTR             Reviewed;         359 AA.
AC   Q0V9X7;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Putative nucleotidyltransferase MAB21L1;
DE            EC=2.7.7.- {ECO:0000305};
DE   AltName: Full=Protein mab-21-like 1;
GN   Name=mab21l1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Putative nucleotidyltransferase required for several aspects
CC       of embryonic development including normal development of the eye (By
CC       similarity). It is unclear whether it displays nucleotidyltransferase
CC       activity in vivo. Binds single-stranded RNA (ssRNA) (By similarity).
CC       {ECO:0000250|UniProtKB:O70299, ECO:0000250|UniProtKB:Q13394}.
CC   -!- SUBUNIT: Monomer. Homodecamer; composed of 2 back to back
CC       homopentamers. The protein may exist as monomer in solution and
CC       oiligomerizes upon ligand binding. {ECO:0000250|UniProtKB:Q13394}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O70299}.
CC   -!- SIMILARITY: Belongs to the mab-21 family. {ECO:0000305}.
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DR   EMBL; BC121357; AAI21358.1; -; mRNA.
DR   RefSeq; NP_001072797.1; NM_001079329.1.
DR   AlphaFoldDB; Q0V9X7; -.
DR   SMR; Q0V9X7; -.
DR   STRING; 8364.ENSXETP00000037322; -.
DR   PaxDb; Q0V9X7; -.
DR   DNASU; 780258; -.
DR   Ensembl; ENSXETT00000037322; ENSXETP00000037322; ENSXETG00000017124.
DR   GeneID; 780258; -.
DR   KEGG; xtr:780258; -.
DR   CTD; 4081; -.
DR   Xenbase; XB-GENE-1001177; mab21l1.
DR   eggNOG; KOG3963; Eukaryota.
DR   HOGENOM; CLU_045315_0_0_1; -.
DR   InParanoid; Q0V9X7; -.
DR   OMA; NSIHIHE; -.
DR   OrthoDB; 771781at2759; -.
DR   PhylomeDB; Q0V9X7; -.
DR   TreeFam; TF315012; -.
DR   Proteomes; UP000008143; Chromosome 2.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000017124; Expressed in brain and 10 other tissues.
DR   ExpressionAtlas; Q0V9X7; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0016779; F:nucleotidyltransferase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR024810; Mab-21_dom.
DR   Pfam; PF03281; Mab-21; 1.
DR   SMART; SM01265; Mab-21; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Magnesium; Metal-binding; Nucleotide-binding;
KW   Nucleotidyltransferase; Nucleus; Reference proteome; Transferase.
FT   CHAIN           1..359
FT                   /note="Putative nucleotidyltransferase MAB21L1"
FT                   /id="PRO_0000312786"
FT   BINDING         23..24
FT                   /ligand="a ribonucleoside 5'-triphosphate"
FT                   /ligand_id="ChEBI:CHEBI:61557"
FT                   /evidence="ECO:0000250|UniProtKB:Q13394"
FT   BINDING         63..66
FT                   /ligand="a ribonucleoside 5'-triphosphate"
FT                   /ligand_id="ChEBI:CHEBI:61557"
FT                   /evidence="ECO:0000250|UniProtKB:Q13394"
FT   BINDING         73
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000250|UniProtKB:Q8N884"
FT   BINDING         75
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000250|UniProtKB:Q8N884"
FT   BINDING         248
FT                   /ligand="a ribonucleoside 5'-triphosphate"
FT                   /ligand_id="ChEBI:CHEBI:61557"
FT                   /evidence="ECO:0000250|UniProtKB:Q13394"
FT   BINDING         252..255
FT                   /ligand="a ribonucleoside 5'-triphosphate"
FT                   /ligand_id="ChEBI:CHEBI:61557"
FT                   /evidence="ECO:0000250|UniProtKB:Q13394"
SQ   SEQUENCE   359 AA;  40938 MW;  B2721129E9903479 CRC64;
     MVAAQAKLVY HLNKYYNEKC QARKAAIAKT IREVCKVVSD VLKEVEVQEP RFISSLNEMD
     NRYEGLEVIS PTEFEVVLYL NQMGVFNFVD DGSLPGCAVL KLSDGRKRSM SLWVEFITAS
     GYLSARKIRS RFQTLVAQAV DKCSYRDVVK MVADTSEVKL RIRDRYVVQI TPAFKCTGIW
     PRSAAHWPLP HIPWPGPNRV AEVKAEGFNL LSKECHTLAG KQSSAESDAW VLQFAEAENR
     LQLGGCRKKC LSLLKTLRDR HLELPGQPLN NYHMKTLVSY ECEKHPRESD WDESCLGDRL
     NGILLQLISC LQCRRCPHYF LPNLDLFQGK PHSALENAAK QTWRLAREIL TNPKSLEKL