MB213_HUMAN
ID MB213_HUMAN Reviewed; 362 AA.
AC Q8N8X9; Q5TDL7;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-MAY-2007, sequence version 2.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Protein mab-21-like 3;
GN Name=MAB21L3; Synonyms=C1orf161;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q8N8X9; Q9ULW3: ABT1; NbExp=3; IntAct=EBI-10268010, EBI-2602396;
CC Q8N8X9; Q6PIK7: AGGF1; NbExp=3; IntAct=EBI-10268010, EBI-10268037;
CC Q8N8X9; Q8N302: AGGF1; NbExp=4; IntAct=EBI-10268010, EBI-747899;
CC Q8N8X9; Q8N2N9-4: ANKRD36B; NbExp=3; IntAct=EBI-10268010, EBI-12170453;
CC Q8N8X9; Q96CW1: AP2M1; NbExp=5; IntAct=EBI-10268010, EBI-297683;
CC Q8N8X9; Q9BUH8: BEGAIN; NbExp=3; IntAct=EBI-10268010, EBI-742722;
CC Q8N8X9; Q5HYN5: CT45A1; NbExp=3; IntAct=EBI-10268010, EBI-12051833;
CC Q8N8X9; Q92997: DVL3; NbExp=3; IntAct=EBI-10268010, EBI-739789;
CC Q8N8X9; Q96JC9: EAF1; NbExp=3; IntAct=EBI-10268010, EBI-769261;
CC Q8N8X9; Q08426: EHHADH; NbExp=3; IntAct=EBI-10268010, EBI-2339219;
CC Q8N8X9; P50402: EMD; NbExp=3; IntAct=EBI-10268010, EBI-489887;
CC Q8N8X9; Q8IZU0: FAM9B; NbExp=3; IntAct=EBI-10268010, EBI-10175124;
CC Q8N8X9; A0A0C3SFZ9: FCHO1; NbExp=3; IntAct=EBI-10268010, EBI-11977403;
CC Q8N8X9; Q9NWQ4-1: GPATCH2L; NbExp=3; IntAct=EBI-10268010, EBI-11959863;
CC Q8N8X9; Q8NBZ0: INO80E; NbExp=3; IntAct=EBI-10268010, EBI-769401;
CC Q8N8X9; P60411: KRTAP10-9; NbExp=3; IntAct=EBI-10268010, EBI-10172052;
CC Q8N8X9; Q9BQD3: KXD1; NbExp=3; IntAct=EBI-10268010, EBI-739657;
CC Q8N8X9; P52954: LBX1; NbExp=3; IntAct=EBI-10268010, EBI-20141748;
CC Q8N8X9; Q96BZ8: LENG1; NbExp=3; IntAct=EBI-10268010, EBI-726510;
CC Q8N8X9; Q9BRK4: LZTS2; NbExp=6; IntAct=EBI-10268010, EBI-741037;
CC Q8N8X9; Q9NPJ6: MED4; NbExp=3; IntAct=EBI-10268010, EBI-394607;
CC Q8N8X9; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-10268010, EBI-741158;
CC Q8N8X9; Q8IXK0: PHC2; NbExp=3; IntAct=EBI-10268010, EBI-713786;
CC Q8N8X9; Q9NZD8: SPG21; NbExp=3; IntAct=EBI-10268010, EBI-742688;
CC Q8N8X9; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-10268010, EBI-5235340;
CC Q8N8X9; Q96MF2: STAC3; NbExp=7; IntAct=EBI-10268010, EBI-745680;
CC Q8N8X9; B7ZLI8: STK19; NbExp=3; IntAct=EBI-10268010, EBI-10176124;
CC Q8N8X9; Q8TBK6: ZCCHC10; NbExp=3; IntAct=EBI-10268010, EBI-597063;
CC Q8N8X9; P49910: ZNF165; NbExp=3; IntAct=EBI-10268010, EBI-741694;
CC -!- SIMILARITY: Belongs to the mab-21 family. {ECO:0000305}.
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DR EMBL; AK096035; BAC04682.1; -; mRNA.
DR EMBL; AL121982; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC128148; AAI28149.1; -; mRNA.
DR EMBL; BC128149; AAI28150.1; -; mRNA.
DR CCDS; CCDS886.1; -.
DR RefSeq; NP_689580.2; NM_152367.2.
DR RefSeq; XP_011538925.1; XM_011540623.2.
DR RefSeq; XP_011538927.1; XM_011540625.2.
DR RefSeq; XP_011538928.1; XM_011540626.2.
DR RefSeq; XP_016855749.1; XM_017000260.1.
DR AlphaFoldDB; Q8N8X9; -.
DR SMR; Q8N8X9; -.
DR BioGRID; 126023; 40.
DR IntAct; Q8N8X9; 29.
DR STRING; 9606.ENSP00000358512; -.
DR BioMuta; MAB21L3; -.
DR DMDM; 147742988; -.
DR PaxDb; Q8N8X9; -.
DR PeptideAtlas; Q8N8X9; -.
DR PRIDE; Q8N8X9; -.
DR ProteomicsDB; 72471; -.
DR Antibodypedia; 49064; 111 antibodies from 11 providers.
DR DNASU; 126868; -.
DR Ensembl; ENST00000369500.4; ENSP00000358512.3; ENSG00000173212.5.
DR Ensembl; ENST00000683341.1; ENSP00000508049.1; ENSG00000173212.5.
DR Ensembl; ENST00000684484.1; ENSP00000506754.1; ENSG00000173212.5.
DR GeneID; 126868; -.
DR KEGG; hsa:126868; -.
DR MANE-Select; ENST00000369500.4; ENSP00000358512.3; NM_152367.3; NP_689580.2.
DR UCSC; uc001egc.1; human.
DR CTD; 126868; -.
DR GeneCards; MAB21L3; -.
DR HGNC; HGNC:26787; MAB21L3.
DR HPA; ENSG00000173212; Tissue enhanced (brain, esophagus, skin).
DR neXtProt; NX_Q8N8X9; -.
DR OpenTargets; ENSG00000173212; -.
DR PharmGKB; PA142672412; -.
DR VEuPathDB; HostDB:ENSG00000173212; -.
DR eggNOG; KOG3963; Eukaryota.
DR GeneTree; ENSGT01050000244827; -.
DR HOGENOM; CLU_045315_1_0_1; -.
DR InParanoid; Q8N8X9; -.
DR OMA; DVWCPGK; -.
DR OrthoDB; 653783at2759; -.
DR PhylomeDB; Q8N8X9; -.
DR TreeFam; TF315012; -.
DR PathwayCommons; Q8N8X9; -.
DR SignaLink; Q8N8X9; -.
DR BioGRID-ORCS; 126868; 7 hits in 1068 CRISPR screens.
DR ChiTaRS; MAB21L3; human.
DR GenomeRNAi; 126868; -.
DR Pharos; Q8N8X9; Tdark.
DR PRO; PR:Q8N8X9; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8N8X9; protein.
DR Bgee; ENSG00000173212; Expressed in esophagus squamous epithelium and 63 other tissues.
DR Genevisible; Q8N8X9; HS.
DR InterPro; IPR034324; Mab-21-like_3.
DR InterPro; IPR024810; Mab-21_dom.
DR PANTHER; PTHR10656:SF30; PTHR10656:SF30; 1.
DR Pfam; PF03281; Mab-21; 1.
DR SMART; SM01265; Mab-21; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..362
FT /note="Protein mab-21-like 3"
FT /id="PRO_0000286584"
FT CONFLICT 338
FT /note="T -> A (in Ref. 1; BAC04682 and 3; AAI28150)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 362 AA; 42357 MW; FE18C96B4E90CE42 CRC64;
MKYLTVGDLE DCLLNKVDLR RQQISQAVEE VQKVVHHLTT NISNQDIRFQ AVPYSDTYNE
NIKVLAPSQF LVTVPIKGLA GYREAREQHW RYYTLQGTRL PCPLRDPEGL QQWLEVEQFM
KSLWQWHETD VNIDGDIVPA KVLLVFRKLV ENAVRTCHLS GKVSLLGNRS AVWVAVETSA
YQVELELVPA VEIPTTWSKK ARWPRCLQRW PSQERVECIK SFGFNLLACS NYHWQLSFLR
AEQVLLEQLD EDGGCRRKCF QVMRHLKEDI WCPGNRPVIT SHHLQTVLFW TCEKYPHFKD
WQVFSKAFLR LVRKLHKCVS QHFLKHYFVR NSNLFQCTNP TELDTVAQKL ATFLKNPQIG
PP
