MB3L1_MOUSE
ID MB3L1_MOUSE Reviewed; 186 AA.
AC Q9D9H3; Q6P8W5; Q9D2S3;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Methyl-CpG-binding domain protein 3-like 1;
DE Short=MBD3-like protein 1;
GN Name=Mbd3l1; Synonyms=Mbd3l;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=C57BL/6J;
RX PubMed=12504854; DOI=10.1006/geno.2002.7001;
RA Jiang C.-L., Jin S.-G., Lee D.-H., Lan Z.-J., Xu X., O'Connor T.R.,
RA Szabo P.E., Mann J.R., Cooney A.J., Pfeifer G.P.;
RT "MBD3L1 and MBD3L2, two new proteins homologous to the methyl-CpG-binding
RT proteins MBD2 and MBD3: characterization of MBD3L1 as a testis-specific
RT transcriptional repressor.";
RL Genomics 80:621-629(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Transcriptional repressor. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Nuclear, in large
CC foci. {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Highly expressed in testis. Not detected in the
CC other tissues tested. {ECO:0000269|PubMed:12504854}.
CC -!- DOMAIN: The N-terminal half of the protein mediates transcription
CC repression. {ECO:0000250}.
CC -!- MISCELLANEOUS: Does not bind methylated DNA. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the MBD3L family. {ECO:0000305}.
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DR EMBL; AY038023; AAK72592.1; -; mRNA.
DR EMBL; AK006927; BAB24794.1; -; mRNA.
DR EMBL; AK018931; BAB31487.1; -; mRNA.
DR EMBL; BC061034; AAH61034.1; -; mRNA.
DR CCDS; CCDS22845.1; -.
DR RefSeq; NP_082833.1; NM_028557.2.
DR RefSeq; XP_006510702.1; XM_006510639.1.
DR RefSeq; XP_006510703.1; XM_006510640.2.
DR AlphaFoldDB; Q9D9H3; -.
DR SMR; Q9D9H3; -.
DR STRING; 10090.ENSMUSP00000063957; -.
DR PhosphoSitePlus; Q9D9H3; -.
DR PaxDb; Q9D9H3; -.
DR PRIDE; Q9D9H3; -.
DR ProteomicsDB; 252739; -.
DR Antibodypedia; 24961; 117 antibodies from 18 providers.
DR DNASU; 73503; -.
DR Ensembl; ENSMUST00000069218; ENSMUSP00000063957; ENSMUSG00000038691.
DR Ensembl; ENSMUST00000213625; ENSMUSP00000149619; ENSMUSG00000038691.
DR Ensembl; ENSMUST00000215255; ENSMUSP00000149425; ENSMUSG00000038691.
DR GeneID; 73503; -.
DR KEGG; mmu:73503; -.
DR UCSC; uc009ogu.1; mouse.
DR CTD; 85509; -.
DR MGI; MGI:1920753; Mbd3l1.
DR VEuPathDB; HostDB:ENSMUSG00000038691; -.
DR eggNOG; KOG4161; Eukaryota.
DR GeneTree; ENSGT00950000183005; -.
DR HOGENOM; CLU_069710_1_0_1; -.
DR InParanoid; Q9D9H3; -.
DR OMA; QQVCWQK; -.
DR OrthoDB; 1431783at2759; -.
DR PhylomeDB; Q9D9H3; -.
DR TreeFam; TF325032; -.
DR BioGRID-ORCS; 73503; 1 hit in 73 CRISPR screens.
DR PRO; PR:Q9D9H3; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q9D9H3; protein.
DR Bgee; ENSMUSG00000038691; Expressed in seminiferous tubule of testis and 5 other tissues.
DR ExpressionAtlas; Q9D9H3; baseline and differential.
DR Genevisible; Q9D9H3; MM.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:MGI.
DR InterPro; IPR032343; MBD2/MBD3_p55-bd.
DR InterPro; IPR025884; MeCpG-bd_2/3_C_dom.
DR Pfam; PF14048; MBD_C; 1.
DR Pfam; PF16564; MBDa; 1.
PE 2: Evidence at transcript level;
KW Nucleus; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..186
FT /note="Methyl-CpG-binding domain protein 3-like 1"
FT /id="PRO_0000096252"
FT REGION 1..104
FT /note="Transcription repressor"
FT /evidence="ECO:0000250"
FT CONFLICT 57..58
FT /note="LE -> FK (in Ref. 3; AAH61034)"
FT /evidence="ECO:0000305"
FT CONFLICT 64
FT /note="C -> S (in Ref. 2; BAB31487)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 186 AA; 20676 MW; F5F45BABE69D2AF0 CRC64;
MGKTSQRKQC DCENPSKPCL STSIPLRMSS YTFKRPVTKI TSHLGNEVRY YQWEETLEKP
EQACWQKRLQ GLQAYSSAGE LLSTSDLAKT LKDLTSTDTV ASASDTQATS IDITSVPTLE
SSSHLANMIP EAGPQILCKE FLVTEQDIIN QERKVKIARE RLAVALIAHK LASEMETVRG
SRKANL
