ID   MB3L3_HUMAN             Reviewed;         208 AA.
AC   A6NE82;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Putative methyl-CpG-binding domain protein 3-like 3;
DE            Short=MBD3-like protein 3;
GN   Name=MBD3L3;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA   Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA   Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA   Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA   Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA   Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA   Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA   Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA   Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA   McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA   Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA   Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA   She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA   Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
CC   -!- INTERACTION:
CC       A6NE82; Q8N7C3: TRIML2; NbExp=3; IntAct=EBI-17422057, EBI-11059915;
CC   -!- MISCELLANEOUS: The MBD3L proteins are encoded by strongly repeated
CC       regions of the 19p13 chromosome. The exact number of functional copies
CC       is unclear, and some of them may represent pseudogenes.
CC   -!- SIMILARITY: Belongs to the MBD3L family. {ECO:0000305}.
CC   -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR   EMBL; AC010606; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS45944.1; -.
DR   RefSeq; NP_001157897.1; NM_001164425.1.
DR   RefSeq; XP_016855269.1; XM_016999780.1.
DR   AlphaFoldDB; A6NE82; -.
DR   SMR; A6NE82; -.
DR   BioGRID; 575961; 1.
DR   IntAct; A6NE82; 1.
DR   STRING; 9606.ENSP00000333183; -.
DR   BioMuta; MBD3L3; -.
DR   MassIVE; A6NE82; -.
DR   PaxDb; A6NE82; -.
DR   PRIDE; A6NE82; -.
DR   Antibodypedia; 57255; 65 antibodies from 15 providers.
DR   DNASU; 653657; -.
DR   Ensembl; ENST00000333843.9; ENSP00000333183.4; ENSG00000182315.10.
DR   Ensembl; ENST00000689071.1; ENSP00000509049.1; ENSG00000182315.10.
DR   Ensembl; ENST00000693237.1; ENSP00000508603.1; ENSG00000182315.10.
DR   GeneID; 653657; -.
DR   KEGG; hsa:653657; -.
DR   MANE-Select; ENST00000333843.9; ENSP00000333183.4; NM_001164425.4; NP_001157897.1.
DR   UCSC; uc021uns.2; human.
DR   CTD; 653657; -.
DR   GeneCards; MBD3L3; -.
DR   HGNC; HGNC:37205; MBD3L3.
DR   HPA; ENSG00000182315; Not detected.
DR   neXtProt; NX_A6NE82; -.
DR   OpenTargets; ENSG00000182315; -.
DR   VEuPathDB; HostDB:ENSG00000182315; -.
DR   eggNOG; KOG4161; Eukaryota.
DR   GeneTree; ENSGT00950000183005; -.
DR   InParanoid; A6NE82; -.
DR   OMA; EVRYNQW; -.
DR   OrthoDB; 1511703at2759; -.
DR   PhylomeDB; A6NE82; -.
DR   TreeFam; TF325032; -.
DR   PathwayCommons; A6NE82; -.
DR   BioGRID-ORCS; 653657; 68 hits in 635 CRISPR screens.
DR   GenomeRNAi; 653657; -.
DR   Pharos; A6NE82; Tdark.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; A6NE82; protein.
DR   Bgee; ENSG00000182315; Expressed in left testis and 7 other tissues.
DR   Genevisible; A6NE82; HS.
DR   InterPro; IPR032343; MBD2/MBD3_p55-bd.
DR   InterPro; IPR025884; MeCpG-bd_2/3_C_dom.
DR   Pfam; PF14048; MBD_C; 1.
DR   Pfam; PF16564; MBDa; 1.
PE   5: Uncertain;
KW   Reference proteome; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..208
FT                   /note="Putative methyl-CpG-binding domain protein 3-like 3"
FT                   /id="PRO_0000349233"
SQ   SEQUENCE   208 AA;  23095 MW;  B8B719F940635EFE CRC64;
     MGEPAFTSFP SPPVLGKLKR NMMPWALQKK REIHMAKAHR RRAARSALPM RLTSCIFRRP
     VTRIRSHPDN QVRRRKGDEH LEKPQQLCAY RRLQALQPCS SQGEGSSPLH LESVLSILAP
     GTAGESLDRA GAERVRSPLE PTPGRFPAVA GGPTPGMGCQ LPPPLSGQLV TPADIRRQAR
     RVKKARERLA KALQADRLAR QAEMLTCR