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ARGP_ECOUT
ID   ARGP_ECOUT              Reviewed;         297 AA.
AC   Q1R7B4;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 2.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=HTH-type transcriptional regulator ArgP {ECO:0000255|HAMAP-Rule:MF_00513};
GN   Name=argP {ECO:0000255|HAMAP-Rule:MF_00513}; Synonyms=iciA;
GN   OrderedLocusNames=UTI89_C3302;
OS   Escherichia coli (strain UTI89 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=364106;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UTI89 / UPEC;
RX   PubMed=16585510; DOI=10.1073/pnas.0600938103;
RA   Chen S.L., Hung C.-S., Xu J., Reigstad C.S., Magrini V., Sabo A.,
RA   Blasiar D., Bieri T., Meyer R.R., Ozersky P., Armstrong J.R., Fulton R.S.,
RA   Latreille J.P., Spieth J., Hooton T.M., Mardis E.R., Hultgren S.J.,
RA   Gordon J.I.;
RT   "Identification of genes subject to positive selection in uropathogenic
RT   strains of Escherichia coli: a comparative genomics approach.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:5977-5982(2006).
CC   -!- FUNCTION: Controls the transcription of genes involved in arginine and
CC       lysine metabolism. {ECO:0000255|HAMAP-Rule:MF_00513}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_00513}.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABE08750.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CP000243; ABE08750.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_000828351.1; NC_007946.1.
DR   AlphaFoldDB; Q1R7B4; -.
DR   SMR; Q1R7B4; -.
DR   EnsemblBacteria; ABE08750; ABE08750; UTI89_C3302.
DR   GeneID; 66673207; -.
DR   KEGG; eci:UTI89_C3302; -.
DR   HOGENOM; CLU_063829_0_0_6; -.
DR   OMA; QQWKLDS; -.
DR   Proteomes; UP000001952; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   HAMAP; MF_00513; HTH_type_ArgP; 1.
DR   InterPro; IPR017685; ArgP.
DR   InterPro; IPR023490; ArgP_Gammaproteobact.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR03298; argP; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Transcription; Transcription regulation.
FT   CHAIN           1..297
FT                   /note="HTH-type transcriptional regulator ArgP"
FT                   /id="PRO_0000258606"
FT   DOMAIN          4..60
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00513"
FT   DNA_BIND        21..40
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00513"
SQ   SEQUENCE   297 AA;  33472 MW;  8AD60B7B6661E3EF CRC64;
     MKRPDYRTLQ ALDAVIRERG FERAAQKLCI TQSAVSQRIK QLENMFGQPL LVRTVPPRPT
     EQGQKLLALL RQVELLEEEW LGDEQTGSTP LLLSLAVNAD SLATWLLPAL APVLADSPIR
     LNLQVEDETR TQERLRRGEV VGAVSIQHQA LPSCLVDKLG ALDYLFVSSK PFAEKYFPNG
     VTRSALLKAP VVAFDHLDDM HQAFLQQNFD LPPGSVPCHI VNSSEAFVQL ARQGTTCCMI
     PHLQIEKELA SGELIDLTPG LFQRRMLYWH RFAPESRMMR KVTDALLDYG HKVLRQD
 
 
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