MB43_HHV11
ID MB43_HHV11 Reviewed; 417 AA.
AC P10227; B9VQH1;
DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT 22-SEP-2009, sequence version 2.
DT 23-FEB-2022, entry version 73.
DE RecName: Full=Membrane protein UL43;
GN ORFNames=UL43;
OS Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Herpesviridae; Alphaherpesvirinae; Simplexvirus.
OX NCBI_TaxID=10299;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=2839594; DOI=10.1099/0022-1317-69-7-1531;
RA McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D.,
RA Perry L.J., Scott J.E., Taylor P.;
RT "The complete DNA sequence of the long unique region in the genome of
RT herpes simplex virus type 1.";
RL J. Gen. Virol. 69:1531-1574(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nonneuroinvasive mutant HF10;
RX PubMed=17218138; DOI=10.1016/j.micinf.2006.10.019;
RA Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.;
RT "Determination and analysis of the DNA sequence of highly attenuated herpes
RT simplex virus type 1 mutant HF10, a potential oncolytic virus.";
RL Microbes Infect. 9:142-149(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17 syn+;
RA Cunningham C., Davison A.J.;
RT "Herpes simplex virus type 1 bacterial artificial chromosome.";
RL Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP IDENTIFICATION OF START CODON.
RC STRAIN=F;
RX PubMed=8892886; DOI=10.1128/jvi.70.11.7663-7668.1996;
RA Carter K.L., Ward P.L., Roizman B.;
RT "Characterization of the products of the U(L)43 gene of herpes simplex
RT virus 1: potential implications for regulation of gene expression by
RT antisense transcription.";
RL J. Virol. 70:7663-7668(1996).
RN [5]
RP SUBCELLULAR LOCATION.
RC STRAIN=F;
RX PubMed=18596102; DOI=10.1128/jvi.00904-08;
RA Loret S., Guay G., Lippe R.;
RT "Comprehensive characterization of extracellular herpes simplex virus type
RT 1 virions.";
RL J. Virol. 82:8605-8618(2008).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}. Note=Not found in extracellular virion.
CC {ECO:0000269|PubMed:18596102}.
CC -!- SIMILARITY: Belongs to the alphaherpesvirinae HHV-1 UL43 family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA32306.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; X14112; CAA32306.1; ALT_INIT; Genomic_DNA.
DR EMBL; DQ889502; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; FJ593289; ACM62266.1; -; Genomic_DNA.
DR PIR; G30088; WMBEF3.
DR RefSeq; YP_009137118.1; NC_001806.2.
DR PRIDE; P10227; -.
DR DNASU; 2703408; -.
DR GeneID; 2703408; -.
DR KEGG; vg:2703408; -.
DR Proteomes; UP000009294; Genome.
DR Proteomes; UP000180652; Genome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0019033; C:viral tegument; IEA:InterPro.
DR InterPro; IPR007764; Herpes_UL43.
DR Pfam; PF05072; Herpes_UL43; 1.
PE 3: Inferred from homology;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..417
FT /note="Membrane protein UL43"
FT /id="PRO_0000116081"
FT TRANSMEM 57..77
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 90..110
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 119..139
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 146..166
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 175..195
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 263..283
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 291..311
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 323..343
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 348..368
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 389..409
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 217..254
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 231..247
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 319
FT /note="P -> A (in strain: 17 syn+ and Nonneuroinvasive
FT mutant HF10)"
FT VARIANT 382..384
FT /note="RLA -> LPVQ (in strain: Nonneuroinvasive mutant
FT HF10)"
FT VARIANT 403
FT /note="V -> A (in strain: Nonneuroinvasive mutant HF10)"
SQ SEQUENCE 417 AA; 42948 MW; D6D48868B4323C5A CRC64;
MLRNDSHRAV SPEDGQGRVD DGRPHLACVG ALARGFMHIW LQAATLGFAG SVVMSRGPYA
NAASGAFAVG CAVLGFMRAP PPLARPTARI YAWLKLAAGG AALVLWSLGE PGTQPGAPAP
GPATQCLALG AAYAALLVLA DDVYPLFLLA PGPLFVGTLG MVVGGLTIGG SARYWWIGGP
AAAALAAAVL AGPGATTARD CFSRACPDHR RVCVITAGES LSRRPPEDPE RPGVPGPPSP
PTPQRSHGPP ADEVAPARVA RPENVWVPVV TFLGAGALAV KTVREHARGT PGPGLPLWPQ
VFLGGHVAVA LTELCQALPP WDLTDPLLFV HAGLQVINLG LVFRFSEVVV YAALGGAVWI
SLAQVLGLRR RLHRKDPGDG ARLAATLRGL FFSVYALGFG VGVLLCPPGS TGGRSGD
