ID   MB43_HHV2H              Reviewed;         414 AA.
AC   P89464;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   02-JUN-2021, entry version 62.
DE   RecName: Full=Membrane protein UL43;
GN   ORFNames=UL43;
OS   Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Simplexvirus.
OX   NCBI_TaxID=10315;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=9499055; DOI=10.1128/jvi.72.3.2010-2021.1998;
RA   Dolan A., Jamieson F.E., Cunningham C., Barnett B.C., McGeoch D.J.;
RT   "The genome sequence of herpes simplex virus type 2.";
RL   J. Virol. 72:2010-2021(1998).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}. Note=Not found in extracellular virion.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the alphaherpesvirinae HHV-1 UL43 family.
CC       {ECO:0000305}.
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DR   EMBL; Z86099; CAB06729.1; -; Genomic_DNA.
DR   RefSeq; YP_009137195.1; NC_001798.2.
DR   PRIDE; P89464; -.
DR   DNASU; 1487330; -.
DR   GeneID; 1487330; -.
DR   KEGG; vg:1487330; -.
DR   Proteomes; UP000001874; Genome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019033; C:viral tegument; IEA:InterPro.
DR   InterPro; IPR007764; Herpes_UL43.
DR   Pfam; PF05072; Herpes_UL43; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..414
FT                   /note="Membrane protein UL43"
FT                   /id="PRO_0000385491"
FT   TRANSMEM        39..59
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        61..81
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        96..116
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        121..141
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        148..168
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        184..204
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        339..359
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        383..403
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          225..253
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   414 AA;  42473 MW;  EBCF9B71094E3CAE CRC64;
     MCRGDSPGVA GGSGEHCLGG DDGDDGRPRL ACVGAIARGF AHLWLQAATL GFVGSVVLSR
     GPYADAMSGA FVIGSTGLGF LRAPPAFARP PTRVCAWLRL VGGGAAVALW SLGEAGAPPG
     VPGPATQCLA LGAAYAALLV LADDVHPLFL LAPRPLFVGT LGVVVGGLTI GGSARYWWID
     PRAAAALTAA VVAGLGTTAA GDSFSKACPR HRRFCVVSAV ESPPPRYAPE DAERPTDHGP
     LLPSTHHQRS PRVCGDGAAR PENIWVPVVT FAGALALAAC AARGSDAAPS GPVLPLWPQV
     FVGGHAAAGL TELCQTLAPR DLTDPLLFAY VGFQVVNHGL MFVVPDIAVY AMLGGAVWIS
     LTQVLGLRRR LHKDPDAGPW AAATLRGLFF SVYALGFAAG VLVRPRMAAS RRSG