ID   MB43_VZVO               Reviewed;         406 AA.
AC   Q4JQW0;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 1.
DT   02-JUN-2021, entry version 25.
DE   RecName: Full=Membrane protein UL43 homolog;
DE   AltName: Full=Membrane protein ORF15;
GN   ORFNames=ORF15;
OS   Varicella-zoster virus (strain Oka vaccine) (HHV-3) (Human herpesvirus 3).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus.
OX   NCBI_TaxID=341980;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate Human/Japan/P-Oka/1970, and
RC   Oka varicella vaccine Biken (V-Oka-Biken);
RX   PubMed=12388706; DOI=10.1128/jvi.76.22.11447-11459.2002;
RA   Gomi Y., Sunamachi H., Mori Y., Nagaike K., Takahashi M., Yamanishi K.;
RT   "Comparison of the complete DNA sequences of the Oka varicella vaccine and
RT   its parental virus.";
RL   J. Virol. 76:11447-11459(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Oka varicella vaccine VarilRix (V-Oka-GSK), and
RC   Oka varicella vaccine Varivax (V-Oka-Merk);
RX   PubMed=18787000; DOI=10.1128/jvi.00777-08;
RA   Tillieux S.L., Halsey W.S., Thomas E.S., Voycik J.J., Sathe G.M.,
RA   Vassilev V.;
RT   "Complete DNA sequences of two oka strain varicella-zoster virus genomes.";
RL   J. Virol. 82:11023-11044(2008).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the alphaherpesvirinae HHV-1 UL43 family.
CC       {ECO:0000305}.
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DR   EMBL; AB097932; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AB097933; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DQ008354; AAY57632.1; -; Genomic_DNA.
DR   EMBL; DQ008355; AAY57703.1; -; Genomic_DNA.
DR   RefSeq; NP_040138.1; NC_001348.1.
DR   IntAct; Q4JQW0; 6.
DR   DNASU; 1487652; -.
DR   GeneID; 1487652; -.
DR   KEGG; vg:1487652; -.
DR   Proteomes; UP000002603; Genome.
DR   Proteomes; UP000008504; Genome.
DR   Proteomes; UP000008505; Genome.
DR   Proteomes; UP000008506; Genome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019033; C:viral tegument; IEA:InterPro.
DR   InterPro; IPR007764; Herpes_UL43.
DR   Pfam; PF05072; Herpes_UL43; 1.
PE   3: Inferred from homology;
KW   Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..406
FT                   /note="Membrane protein UL43 homolog"
FT                   /id="PRO_0000385492"
FT   TRANSMEM        48..68
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        71..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        103..123
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        126..146
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        162..182
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        188..208
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        266..286
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        299..319
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        339..359
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        386..406
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   406 AA;  44525 MW;  726DF7D084DE5387 CRC64;
     MAVNGERAVH DENLGVLDRE LIRAQSIQGC VGNPQECNSC AITSASRLFL VGLQASVITS
     GLILQYHVCE AAVNATIMGL IVVSGLWPTS VKFLRTLAKL GRCLQTVVVL GFAVLWAVGC
     PISRDLPFVE LLGISISAIT GTVAAVHIHY YNFVTTFNGP HIYFYVMMLG TGLGGLLTVI
     LYMYVSKYEV LIGLCISIVT LVSIVDAATD LQDTCIYRKN RHKQLNTYTD LGFAVVYTQN
     DRGRVCDHRE SSRTLKRVFK GIRIMSVIPP VLYIVTPLMW AISHIIKLNH FIKLTQVTLA
     VSIGGHIIAF GLQGFAVLYQ EKKNLWVIVL YTTTSVTGIA VTFAGISWGA IIILTSTVAA
     GLTCIQMMRL SVKPIDCFMA SHITKVYHVC VYIIINLCYL CGTYVS