MBB1A_DANRE
ID MBB1A_DANRE Reviewed; 1269 AA.
AC Q6DRL5; Q6PEG6;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Myb-binding protein 1A-like protein;
GN Name=mybbp1a;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15256591; DOI=10.1073/pnas.0403929101;
RA Amsterdam A., Nissen R.M., Sun Z., Swindell E.C., Farrington S.,
RA Hopkins N.;
RT "Identification of 315 genes essential for early zebrafish development.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:12792-12797(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-650.
RC TISSUE=Embryo;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-810, AND IDENTIFICATION BY
RP MASS SPECTROMETRY.
RC TISSUE=Embryo;
RX PubMed=18307296; DOI=10.1021/pr700667w;
RA Lemeer S., Pinkse M.W.H., Mohammed S., van Breukelen B., den Hertog J.,
RA Slijper M., Heck A.J.R.;
RT "Online automated in vivo zebrafish phosphoproteomics: from large-scale
RT analysis down to a single embryo.";
RL J. Proteome Res. 7:1555-1564(2008).
CC -!- FUNCTION: May activate or repress transcription via interactions with
CC sequence specific DNA-binding proteins. May play a role in the
CC repression of the circadian clock gene expression.
CC {ECO:0000250|UniProtKB:Q7TPV4}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000250|UniProtKB:Q7TPV4}.
CC -!- SIMILARITY: Belongs to the MYBBP1A family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH58070.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
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DR EMBL; AY648744; AAT68062.1; -; mRNA.
DR EMBL; BC058070; AAH58070.1; ALT_SEQ; mRNA.
DR AlphaFoldDB; Q6DRL5; -.
DR STRING; 7955.ENSDARP00000028271; -.
DR iPTMnet; Q6DRL5; -.
DR PaxDb; Q6DRL5; -.
DR PRIDE; Q6DRL5; -.
DR ZFIN; ZDB-GENE-030131-9864; mybbp1a.
DR eggNOG; KOG1926; Eukaryota.
DR InParanoid; Q6DRL5; -.
DR PhylomeDB; Q6DRL5; -.
DR Reactome; R-DRE-5250924; B-WICH complex positively regulates rRNA expression.
DR PRO; PR:Q6DRL5; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0003714; F:transcription corepressor activity; IBA:GO_Central.
DR GO; GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR007015; DNA_pol_V/MYBBP1A.
DR PANTHER; PTHR13213; PTHR13213; 1.
DR Pfam; PF04931; DNA_pol_phi; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 1: Evidence at protein level;
KW Activator; Biological rhythms; Nucleus; Phosphoprotein; Reference proteome;
KW Repressor; Transcription; Transcription regulation.
FT CHAIN 1..1269
FT /note="Myb-binding protein 1A-like protein"
FT /id="PRO_0000096254"
FT REGION 708..783
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1163..1269
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 708..731
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 732..782
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1163..1181
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1195..1220
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1237..1251
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 810
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18307296"
FT CONFLICT 11
FT /note="E -> G (in Ref. 2; AAH58070)"
FT /evidence="ECO:0000305"
FT CONFLICT 55
FT /note="D -> N (in Ref. 2; AAH58070)"
FT /evidence="ECO:0000305"
FT CONFLICT 325
FT /note="L -> P (in Ref. 2; AAH58070)"
FT /evidence="ECO:0000305"
FT CONFLICT 461..463
FT /note="IVE -> MVD (in Ref. 2; AAH58070)"
FT /evidence="ECO:0000305"
FT CONFLICT 516
FT /note="V -> I (in Ref. 2; AAH58070)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1269 AA; 144011 MW; 12DAC70250F6A7E7 CRC64;
MVAVMQTDMG ETENSAVRPK VTDAKGILKQ NRQFLDYFWD IAKPDRQIRL KAIEDLINYL
KNSEQADELK YTLKRLVDGL SHTREDARSG YSVALAQLLS VFEEISLKST LNSVKEKHNL
LTASKKLIRN AVFGNFFGVL ALSQSTRLHK EPQVMLECVQ LLQSLSEYRE HLRDLPRKTM
VDILSETSQD VFEEVLFSAL QSDLTSALKS PEQLELLLVA LQKFPSVLKP KKLKKLLGTT
AVITKQNMPR LVEVLKTAAR SVKKENILPA VALDLLQVSL REDNFEMFWT DAIITGMMSE
MPGPTHYLSF RLLGASLPLL SIPQLQFVLS GDVMRQYGEH TMSAQMPDRF KFAPEMAGYV
GEFMQSCTDP DKQLVVVLGF TQLTNQGNPV VPSYWKALEN MHPSAVQRYV DWLIEAFCKP
QLENCLDFST RRQKGNQEAA VESESCVSRF RKWIIPRLTF IVENQQIKKQ EALVMKVVRF
IFFHAFFEVK KPTSEIPETT QALSVPINQQ TRTAVVSGFY SLLQALNSMM VLGESVEVQG
LNFRRIVGVQ ADGSMWIYSV FQFASMLLNQ NKYVKSLQSF SPEQRQGWDS VLESVEALRK
KAKTASSPEH TAFQQLFLLI GIQMFTSPEE SLDLLKDLQT CMEKAQAKKS KKKKATDEPH
WVEVIVEILL SLVSQPSRLV RSVCKTVFGR ICPHLTQAAL SSILNVLDPN KDEDESGVVV
TDDKKRKLKE EDEDDDDEEE DDDNDEGDDD DDDDDEEEGG EEGEESSDSS DDEEEDEAME
EGQEVDQNFR LELMKVLQGQ NALATEEDGS DDEELDDAAM MKLDGSLASL FLEQRKKIQA
KKDEKDRLNK EKGLVRDFKI KVLDMVEVFL SKQGFSPLVL GMVEPLLSVI ENGMSSESSQ
PEQDYLRRVA DIFRNRLCRG KFYCKEIDGR EAELHEMLER LIGRAQKLTD SSVALYYFSA
ALYVLKVLRG SVVDQELSTM GKVEVERATT CLKNALTSFM TKRKSPLTGA MFIDLFHRFP
VLCVNLMDTA LENITAGLRD HQQGQACFIM LKALQCKHVK NLMTGEQTTE LYKKVVDQLT
KSLENVQCKN KTAHDKVVKA LELCLHVVKI VLNQKMRVNL ELLQDVLASM NAEGCLEKTG
KLEDTYWSVM RLFGVIKPKM EKVKKVPEAE QTEETTKKKK GFLPETKKRK NRKKPTILEG
KETETPVEKT PEGASGEGKK NKNKKKNKKR KQQAGEETQD QPTPKKAKMQ QQQQQKQKKK
KKKKGADGE
