ID   MBCA_MYCBO              Reviewed;         113 AA.
AC   P64910; A0A1R3XZV5; Q10868; X2BJS5;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Mycobacterial cidal antitoxin MbcA {ECO:0000250|UniProtKB:P9WLP7};
GN   Name=mbcA; OrderedLocusNames=BQ2027_MB2012C;
OS   Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=233413;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA   Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA   Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA   Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA   Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT   "The complete genome sequence of Mycobacterium bovis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA   Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA   Robbe-Austerman S., Gordon S.V.;
RT   "Updated reference genome sequence and annotation of Mycobacterium bovis
RT   AF2122/97.";
RL   Genome Announc. 5:E00157-E00157(2017).
CC   -!- FUNCTION: Antitoxin component of a type II toxin-antitoxin (TA) system.
CC       Neutralizes the activity of cognate toxin MbcT by blocking access to
CC       the toxin active site. {ECO:0000250|UniProtKB:P9WLP7}.
CC   -!- SUBUNIT: Forms a heterotetramer with cognate toxin MbcT.
CC       {ECO:0000250|UniProtKB:P9WLP9}.
CC   -!- SIMILARITY: Belongs to the MbcA/ParS/Xre antitoxin family.
CC       {ECO:0000305}.
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DR   EMBL; LT708304; SIU00618.1; -; Genomic_DNA.
DR   RefSeq; NP_855662.1; NC_002945.3.
DR   RefSeq; WP_003410003.1; NC_002945.4.
DR   AlphaFoldDB; P64910; -.
DR   SMR; P64910; -.
DR   EnsemblBacteria; SIU00618; SIU00618; BQ2027_MB2012C.
DR   PATRIC; fig|233413.5.peg.2210; -.
DR   OMA; ETRLWLH; -.
DR   Proteomes; UP000001419; Chromosome.
DR   InterPro; IPR024467; Xre/MbcA/ParS-like_toxin-bd.
DR   Pfam; PF09722; DUF2384; 1.
PE   3: Inferred from homology;
KW   Toxin-antitoxin system.
FT   CHAIN           1..113
FT                   /note="Mycobacterial cidal antitoxin MbcA"
FT                   /id="PRO_0000014117"
SQ   SEQUENCE   113 AA;  12488 MW;  41978D1BE45E74C9 CRC64;
     MGVNVLASTV SGAIERLGLT YEEVGDIVDA SPRSVARWTA GQVVPQRLNK QRLIELAYVA
     DALAEVLPRD QANVWMFSPN RLLEHRKPAD LVRDGEYQRV LALIDAMAEG VFV