ID   MBCA_MYCTO              Reviewed;         113 AA.
AC   P9WLP6; L0TB09; P64909; Q10868;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 35.
DE   RecName: Full=Mycobacterial cidal antitoxin MbcA {ECO:0000250|UniProtKB:P9WLP7};
GN   Name=mbcA; OrderedLocusNames=MT2044;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
RN   [2]
RP   INDUCTION IN MOUSE INFECTION MODEL.
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=20628579; DOI=10.1371/journal.ppat.1000988;
RA   Homolka S., Niemann S., Russell D.G., Rohde K.H.;
RT   "Functional genetic diversity among Mycobacterium tuberculosis complex
RT   clinical isolates: delineation of conserved core and lineage-specific
RT   transcriptomes during intracellular survival.";
RL   PLoS Pathog. 6:E1000988-E1000988(2010).
CC   -!- FUNCTION: Antitoxin component of a type II toxin-antitoxin (TA) system.
CC       Neutralizes the activity of cognate toxin MbcT by blocking access to
CC       the toxin active site. {ECO:0000250|UniProtKB:P9WLP7}.
CC   -!- SUBUNIT: Forms a heterotetramer with cognate toxin MbcT.
CC       {ECO:0000250|UniProtKB:P9WLP9}.
CC   -!- INDUCTION: Expression probably induced in both active and resting
CC       C57BL/6 mouse macrophages. {ECO:0000269|PubMed:20628579}.
CC   -!- SIMILARITY: Belongs to the MbcA/ParS/Xre antitoxin family.
CC       {ECO:0000305}.
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DR   EMBL; AE000516; AAK46320.1; -; Genomic_DNA.
DR   PIR; D70757; D70757.
DR   RefSeq; WP_003410003.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WLP6; -.
DR   SMR; P9WLP6; -.
DR   EnsemblBacteria; AAK46320; AAK46320; MT2044.
DR   KEGG; mtc:MT2044; -.
DR   PATRIC; fig|83331.31.peg.2201; -.
DR   HOGENOM; CLU_148617_0_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   InterPro; IPR024467; Xre/MbcA/ParS-like_toxin-bd.
DR   Pfam; PF09722; DUF2384; 1.
PE   2: Evidence at transcript level;
KW   Toxin-antitoxin system.
FT   CHAIN           1..113
FT                   /note="Mycobacterial cidal antitoxin MbcA"
FT                   /id="PRO_0000427442"
SQ   SEQUENCE   113 AA;  12488 MW;  41978D1BE45E74C9 CRC64;
     MGVNVLASTV SGAIERLGLT YEEVGDIVDA SPRSVARWTA GQVVPQRLNK QRLIELAYVA
     DALAEVLPRD QANVWMFSPN RLLEHRKPAD LVRDGEYQRV LALIDAMAEG VFV