MBD5_HUMAN
ID MBD5_HUMAN Reviewed; 1494 AA.
AC Q9P267; A5HMQ4; A7E2B1; Q53SR1; Q9NUV6;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 3.
DT 03-AUG-2022, entry version 163.
DE RecName: Full=Methyl-CpG-binding domain protein 5;
DE AltName: Full=Methyl-CpG-binding protein MBD5;
GN Name=MBD5; Synonyms=KIAA1461;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INVOLVEMENT IN MRD1, AND VARIANTS
RP MRD1 ILE-144; HIS-461; GLU-654; THR-655; ASN-677; THR-857 AND ILE-1048.
RC TISSUE=Brain;
RX PubMed=17847001; DOI=10.1086/521274;
RA Wagenstaller J., Spranger S., Lorenz-Depiereux B., Kazmierczak B.,
RA Nathrath M., Wahl D., Heye B., Glaser D., Liebscher V., Meitinger T.,
RA Strom T.M.;
RT "Copy-number variations measured by single-nucleotide-polymorphism
RT oligonucleotide arrays in patients with mental retardation.";
RL Am. J. Hum. Genet. 81:768-779(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=10819331; DOI=10.1093/dnares/7.2.143;
RA Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XVII. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 7:143-150(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 520-1494 (ISOFORM 2).
RC TISSUE=Urinary bladder;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 578-1494 (ISOFORM 2).
RC TISSUE=Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [7]
RP TISSUE SPECIFICITY.
RX PubMed=12529184; DOI=10.1186/1471-2164-4-1;
RA Roloff T.C., Ropers H.-H., Nuber U.A.;
RT "Comparative study of methyl-CpG-binding domain proteins.";
RL BMC Genomics 4:1-1(2003).
RN [8]
RP SUBCELLULAR LOCATION, AND MUTAGENESIS OF PRO-39 AND 1399-TRP-PRO-1400.
RX PubMed=20700456; DOI=10.1371/journal.pone.0011982;
RA Laget S., Joulie M., Le Masson F., Sasai N., Christians E., Pradhan S.,
RA Roberts R.J., Defossez P.A.;
RT "The human proteins MBD5 and MBD6 associate with heterochromatin but they
RT do not bind methylated DNA.";
RL PLoS ONE 5:E11982-E11982(2010).
RN [9]
RP INVOLVEMENT IN MRD1.
RX PubMed=22726846; DOI=10.1016/j.ajhg.2012.05.003;
RA Kleefstra T., Kramer J.M., Neveling K., Willemsen M.H., Koemans T.S.,
RA Vissers L.E., Wissink-Lindhout W., Fenckova M., van den Akker W.M.,
RA Kasri N.N., Nillesen W.M., Prescott T., Clark R.D., Devriendt K.,
RA van Reeuwijk J., de Brouwer A.P., Gilissen C., Zhou H., Brunner H.G.,
RA Veltman J.A., Schenck A., van Bokhoven H.;
RT "Disruption of an EHMT1-associated chromatin-modification module causes
RT intellectual disability.";
RL Am. J. Hum. Genet. 91:73-82(2012).
CC -!- FUNCTION: Binds to heterochromatin. Does not interact with either
CC methylated or unmethylated DNA (in vitro).
CC -!- INTERACTION:
CC Q9P267-2; Q9UHA2: SS18L2; NbExp=3; IntAct=EBI-17671489, EBI-10962400;
CC Q9P267-2; P36508: ZNF76; NbExp=3; IntAct=EBI-17671489, EBI-7254550;
CC -!- SUBCELLULAR LOCATION: [Isoform 1]: Nucleus. Chromosome. Note=Associated
CC with pericentric heterochromatin.
CC -!- SUBCELLULAR LOCATION: [Isoform 2]: Nucleus. Note=Not associated with
CC pericentric heterochromatin.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9P267-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9P267-2; Sequence=VSP_011083, VSP_011084;
CC -!- TISSUE SPECIFICITY: Detected in heart, placenta, liver, skeletal
CC muscle, kidney and pancreas. {ECO:0000269|PubMed:12529184}.
CC -!- DOMAIN: Both MBD and PWWP domains are necessary for chromocentric
CC localization.
CC -!- DISEASE: Intellectual developmental disorder, autosomal dominant 1
CC (MRD1) [MIM:156200]: A disorder characterized by significantly below
CC average general intellectual functioning associated with impairments in
CC adaptive behavior and manifested during the developmental period.
CC {ECO:0000269|PubMed:17847001, ECO:0000269|PubMed:22726846}. Note=The
CC disease is caused by variants affecting the gene represented in this
CC entry.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA92013.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAA95985.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; EF542797; ABQ18300.1; -; mRNA.
DR EMBL; AB040894; BAA95985.1; ALT_INIT; mRNA.
DR EMBL; AC016731; AAY14912.1; -; Genomic_DNA.
DR EMBL; CH471058; EAX11552.1; -; Genomic_DNA.
DR EMBL; BC014534; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC150264; AAI50265.1; -; mRNA.
DR EMBL; AK001975; BAA92013.1; ALT_INIT; mRNA.
DR CCDS; CCDS33302.1; -. [Q9P267-1]
DR RefSeq; NP_060798.2; NM_018328.4. [Q9P267-1]
DR AlphaFoldDB; Q9P267; -.
DR BioGRID; 120892; 29.
DR IntAct; Q9P267; 30.
DR STRING; 9606.ENSP00000386049; -.
DR iPTMnet; Q9P267; -.
DR PhosphoSitePlus; Q9P267; -.
DR BioMuta; MBD5; -.
DR DMDM; 296439306; -.
DR jPOST; Q9P267; -.
DR MassIVE; Q9P267; -.
DR PaxDb; Q9P267; -.
DR PeptideAtlas; Q9P267; -.
DR PRIDE; Q9P267; -.
DR ProteomicsDB; 83738; -. [Q9P267-1]
DR ProteomicsDB; 83739; -. [Q9P267-2]
DR Antibodypedia; 33627; 115 antibodies from 19 providers.
DR DNASU; 55777; -.
DR Ensembl; ENST00000407073.5; ENSP00000386049.1; ENSG00000204406.14. [Q9P267-1]
DR Ensembl; ENST00000627651.2; ENSP00000486370.1; ENSG00000204406.14. [Q9P267-2]
DR GeneID; 55777; -.
DR KEGG; hsa:55777; -.
DR UCSC; uc002twm.5; human. [Q9P267-1]
DR CTD; 55777; -.
DR DisGeNET; 55777; -.
DR GeneCards; MBD5; -.
DR GeneReviews; MBD5; -.
DR HGNC; HGNC:20444; MBD5.
DR HPA; ENSG00000204406; Low tissue specificity.
DR MalaCards; MBD5; -.
DR MIM; 156200; phenotype.
DR MIM; 611472; gene.
DR neXtProt; NX_Q9P267; -.
DR OpenTargets; ENSG00000204406; -.
DR Orphanet; 228402; 2q23.1 microdeletion syndrome.
DR Orphanet; 178469; Autosomal dominant non-syndromic intellectual disability.
DR PharmGKB; PA134924244; -.
DR VEuPathDB; HostDB:ENSG00000204406; -.
DR eggNOG; ENOG502QTC7; Eukaryota.
DR GeneTree; ENSGT00530000064137; -.
DR HOGENOM; CLU_003105_0_0_1; -.
DR InParanoid; Q9P267; -.
DR PhylomeDB; Q9P267; -.
DR TreeFam; TF106391; -.
DR PathwayCommons; Q9P267; -.
DR Reactome; R-HSA-5689603; UCH proteinases.
DR SignaLink; Q9P267; -.
DR SIGNOR; Q9P267; -.
DR BioGRID-ORCS; 55777; 3 hits in 1072 CRISPR screens.
DR ChiTaRS; MBD5; human.
DR GenomeRNAi; 55777; -.
DR Pharos; Q9P267; Tbio.
DR PRO; PR:Q9P267; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q9P267; protein.
DR Bgee; ENSG00000204406; Expressed in calcaneal tendon and 164 other tissues.
DR ExpressionAtlas; Q9P267; baseline and differential.
DR Genevisible; Q9P267; HS.
DR GO; GO:0010369; C:chromocenter; IDA:UniProtKB.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0030496; C:midbody; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0003682; F:chromatin binding; IDA:UniProtKB.
DR GO; GO:0042593; P:glucose homeostasis; ISS:UniProtKB.
DR GO; GO:0007399; P:nervous system development; IMP:UniProtKB.
DR GO; GO:0060399; P:positive regulation of growth hormone receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0050795; P:regulation of behavior; IMP:UniProtKB.
DR GO; GO:0040014; P:regulation of multicellular organism growth; ISS:UniProtKB.
DR InterPro; IPR016177; DNA-bd_dom_sf.
DR InterPro; IPR037385; MBD5/MBD6.
DR InterPro; IPR001739; Methyl_CpG_DNA-bd.
DR InterPro; IPR000313; PWWP_dom.
DR PANTHER; PTHR16112; PTHR16112; 1.
DR SMART; SM00391; MBD; 1.
DR SUPFAM; SSF54171; SSF54171; 1.
DR PROSITE; PS50982; MBD; 1.
DR PROSITE; PS50812; PWWP; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Chromosome; Intellectual disability; Nucleus;
KW Reference proteome.
FT CHAIN 1..1494
FT /note="Methyl-CpG-binding domain protein 5"
FT /id="PRO_0000096266"
FT DOMAIN 11..81
FT /note="MBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00338"
FT DOMAIN 1385..1447
FT /note="PWWP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00162"
FT REGION 123..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 200..274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 329..350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 450..522
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 594..641
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 809..848
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1154..1173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1345..1375
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1468..1494
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 126..140
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 222..236
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 256..271
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 330..346
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 455..471
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 497..512
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 594..634
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 841..851
FT /note="GSGPSSSIAIA -> MVLLEKSTQRY (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_011083"
FT VAR_SEQ 852..1494
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_011084"
FT VARIANT 144
FT /note="T -> I (in MRD1; unknown pathological significance;
FT dbSNP:rs1553518402)"
FT /evidence="ECO:0000269|PubMed:17847001"
FT /id="VAR_037561"
FT VARIANT 461
FT /note="R -> H (in MRD1; unknown pathological significance;
FT dbSNP:rs139964770)"
FT /evidence="ECO:0000269|PubMed:17847001"
FT /id="VAR_037562"
FT VARIANT 654
FT /note="D -> E (in MRD1; unknown pathological significance;
FT dbSNP:rs139953766)"
FT /evidence="ECO:0000269|PubMed:17847001"
FT /id="VAR_037563"
FT VARIANT 655
FT /note="A -> T (in MRD1; unknown pathological significance;
FT dbSNP:rs576930680)"
FT /evidence="ECO:0000269|PubMed:17847001"
FT /id="VAR_037564"
FT VARIANT 677
FT /note="S -> N (in dbSNP:rs114314967)"
FT /evidence="ECO:0000269|PubMed:17847001"
FT /id="VAR_037565"
FT VARIANT 857
FT /note="A -> T (in MRD1; unknown pathological significance;
FT dbSNP:rs769330358)"
FT /evidence="ECO:0000269|PubMed:17847001"
FT /id="VAR_037566"
FT VARIANT 1048
FT /note="T -> I (in MRD1; unknown pathological significance;
FT dbSNP:rs145475623)"
FT /evidence="ECO:0000269|PubMed:17847001"
FT /id="VAR_037567"
FT MUTAGEN 39
FT /note="P->A: Shows diffuse nuclear pattern."
FT /evidence="ECO:0000269|PubMed:20700456"
FT MUTAGEN 1399..1400
FT /note="WP->AA: Shows diffuse nuclear pattern."
FT /evidence="ECO:0000269|PubMed:20700456"
FT CONFLICT 1020
FT /note="R -> I (in Ref. 2; BAA95985 and 5; AAI50265)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1494 AA; 159895 MW; E323E9F6D861E7E9 CRC64;
MNGGKECDGG DKEGGLPAIQ VPVGWQRRVD QNGVLYVSPS GSLLSCLEQV KTYLLTDGTC
KCGLECPLIL PKVFNFDPGA AVKQRTAEDV KADEDVTKLC IHKRKIIAVA TLHKSMEAPH
PSLVLTSPGG GTNATPVVPS RAATPRSVRN KSHEGITNSV MPECKNPFKL MIGSSNAMGR
LYVQELPGSQ QQELHPVYPR QRLGSSEHGQ KSPFRGSHGG LPSPASSGSQ IYGDGSISPR
TDPLGSPDVF TRSNPGFHGA PNSSPIHLNR TPLSPPSVML HGSPVQSSCA MAGRTNIPLS
PTLTTKSPVM KKPMCNFSTN MEIPRAMFHH KPPQGPPPPP PPSCALQKKP LTSEKDPLGI
LDPIPSKPVN QNPVIINPTS FHSNVHSQVP MMNVSMPPAV VPLPSNLPLP TVKPGHMNHG
SHVQRVQHSA STSLSPSPVT SPVHMMGTGI GRIEASPQRS RSSSTSSDHG NFMMPPVGPQ
ATSSGIKVPP RSPRSTIGSP RPSMPSSPST KSDGHHQYKD IPNPLIAGIS NVLNTPSSAA
FPTASAGSSS VKSQPGLLGM PLNQILNQHN AASFPASSLL SAAAKAQLAN QNKLAGNNSS
SSSNSGAVAG SGNTEGHSTL NTMFPPTANM LLPTGEGQSG RAALRDKLMS QQKDALRKRK
QPPTTVLSLL RQSQMDSSAV PKPGPDLLRK QGQGSFPISS MSQLLQSMSC QSSHLSSNST
PGCGASNTAL PCSANQLHFT DPSMNSSVLQ NIPLRGEAVH CHNANTNFVH SNSPVPNHHL
AGLINQIQAS GNCGMLSQSG MALGNSLHPN PPQSRISTSS TPVIPNSIVS SYNQTSSEAG
GSGPSSSIAI AGTNHPAITK TTSVLQDGVI VTTAAGNPLQ SQLPIGSDFP FVGQEHALHF
PSNSTSNNHL PHPLNPSLLS SLPISLPVNQ QHLLNQNLLN ILQPSAGEGD MSSINNTLSN
HQLTHLQSLL NNNQMFPPNQ QQQQLLQGYQ NLQAFQGQST IPCPANNNPM ACLFQNFQVR
MQEDAALLNK RISTQPGLTA LPENPNTTLP PFQDTPCELQ PRIDPSLGQQ VKDGLVVGGP
GDASVDAIYK AVVDAASKGM QVVITTAVNS TTQISPIPAL SAMSAFTASI GDPLNLSSAV
SAVIHGRNMG GVDHDGRLRN SRGARLPKNL DHGKNVNEGD GFEYFKSASC HTSKKQWDGE
QSPRGERNRW KYEEFLDHPG HIHSSPCHER PNNVSTLPFL PGEQHPILLP PRNCPGDKIL
EENFRYNNYK RTMMSFKERL ENTVERCAHI NGNRPRQSRG FGELLSTAKQ DLVLEEQSPS
SSNSLENSLV KDYIHYNGDF NAKSVNGCVP SPSDAKSISS EDDLRNPDSP SSNELIHYRP
RTFNVGDLVW GQIKGLTSWP GKLVREDDVH NSCQQSPEEG KVEPEKLKTL TEGLEAYSRV
RKRNRKSGKL NNHLEAAIHE AMSELDKMSG TVHQIPQGDR QMRPPKPKRR KISR
