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MBF1C_ARATH
ID   MBF1C_ARATH             Reviewed;         148 AA.
AC   Q9LV58; Q8LE67;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 132.
DE   RecName: Full=Multiprotein-bridging factor 1c;
GN   Name=MBF1C; OrderedLocusNames=At3g24500; ORFNames=MOB24.13;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10907853; DOI=10.1093/dnares/7.3.217;
RA   Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence
RT   features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC
RT   clones.";
RL   DNA Res. 7:217-221(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA   Feldmann K.A.;
RT   "Full-length cDNA from Arabidopsis thaliana.";
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA   Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA   Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA   Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA   Shinozaki K.;
RT   "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL   Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   FUNCTION, TISSUE SPECIFICITY, AND INDUCTION BY ABSCISIC ACID.
RX   PubMed=14988493; DOI=10.1093/pcp/pch017;
RA   Tsuda K., Tsuji T., Hirose S., Yamazaki K.;
RT   "Three Arabidopsis MBF1 homologs with distinct expression profiles play
RT   roles as transcriptional co-activators.";
RL   Plant Cell Physiol. 45:225-231(2004).
RN   [7]
RP   TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND INDUCTION.
RX   PubMed=15451167; DOI=10.1016/j.bbaexp.2004.08.004;
RA   Tsuda K., Yamazaki K.;
RT   "Structure and expression analysis of three subtypes of Arabidopsis MBF1
RT   genes.";
RL   Biochim. Biophys. Acta 1680:1-10(2004).
RN   [8]
RP   SUBCELLULAR LOCATION.
RX   PubMed=16283071; DOI=10.1007/s10265-005-0238-y;
RA   Sugikawa Y., Ebihara S., Tsuda K., Niwa Y., Yamazaki K.;
RT   "Transcriptional coactivator MBF1s from Arabidopsis predominantly localize
RT   in nucleolus.";
RL   J. Plant Res. 118:431-437(2005).
RN   [9]
RP   FUNCTION, INDUCTION BY HEAT STRESS, AND INDUCTION BY DEHYDRATION.
RX   PubMed=16244138; DOI=10.1104/pp.105.070110;
RA   Suzuki N., Rizhsky L., Liang H., Shuman J., Shulaev V., Mittler R.;
RT   "Enhanced tolerance to environmental stress in transgenic plants expressing
RT   the transcriptional coactivator multiprotein bridging factor 1c.";
RL   Plant Physiol. 139:1313-1322(2005).
RN   [10]
RP   FUNCTION, SUBCELLULAR LOCATION, INDUCTION BY HEAT STRESS, INTERACTION WITH
RP   TPS5, AND DISRUPTION PHENOTYPE.
RX   PubMed=18201973; DOI=10.1074/jbc.m709187200;
RA   Suzuki N., Bajad S., Shuman J., Shulaev V., Mittler R.;
RT   "The transcriptional co-activator MBF1c is a key regulator of
RT   thermotolerance in Arabidopsis thaliana.";
RL   J. Biol. Chem. 283:9269-9275(2008).
CC   -!- FUNCTION: Transcriptional coactivator that stimulates transcriptional
CC       activity by bridging regulatory proteins and TBP, thereby recruiting
CC       TBP to promoters occupied by DNA-binding regulators. Involved in the
CC       tolerance to heat and osmotic stress by partially activating the
CC       ethylene-response signal transduction pathway.
CC       {ECO:0000269|PubMed:14988493, ECO:0000269|PubMed:16244138,
CC       ECO:0000269|PubMed:18201973}.
CC   -!- SUBUNIT: Binds to TPS5.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus. Cytoplasm.
CC       Note=PubMed:16283071 shows a localization restricted to the nucleus and
CC       not altered by heat or ABA treatment, while PubMed:18201973 describes a
CC       transport from the cytoplasm to the nucleus induced by heat stress.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=1;
CC         Comment=A number of isoforms are produced. According to EST
CC         sequences.;
CC       Name=1;
CC         IsoId=Q9LV58-1; Sequence=Displayed;
CC   -!- TISSUE SPECIFICITY: Expressed in leaves, roots, stems, flowers,
CC       siliques and shoots. Not detected in seeds.
CC       {ECO:0000269|PubMed:14988493, ECO:0000269|PubMed:15451167}.
CC   -!- DEVELOPMENTAL STAGE: Scarcely expressed in early stages, restricted to
CC       the shoot apical meristem in 14-day-old seedlings and detected in all
CC       tissues in 28-day-old seedlings. {ECO:0000269|PubMed:15451167}.
CC   -!- INDUCTION: By abscisic acid, H(2)O(2), heat treatment, dehydration and
CC       high salt, but not by cold treatment, 2,4-D, ACC, methyl jasmonate or
CC       salicylic acid. {ECO:0000269|PubMed:14988493,
CC       ECO:0000269|PubMed:15451167, ECO:0000269|PubMed:16244138,
CC       ECO:0000269|PubMed:18201973}.
CC   -!- DISRUPTION PHENOTYPE: Plants are deficient in basal thermotolerance.
CC       {ECO:0000269|PubMed:18201973}.
CC   -!- SIMILARITY: Belongs to the MBF1 family. {ECO:0000305}.
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DR   EMBL; AB020746; BAB01997.1; -; Genomic_DNA.
DR   EMBL; CP002686; AEE76905.1; -; Genomic_DNA.
DR   EMBL; BT004761; AAO44027.1; -; mRNA.
DR   EMBL; AY085593; AAM62814.1; -; mRNA.
DR   EMBL; AK227957; BAE99925.1; -; mRNA.
DR   RefSeq; NP_189093.1; NM_113358.3. [Q9LV58-1]
DR   AlphaFoldDB; Q9LV58; -.
DR   SMR; Q9LV58; -.
DR   BioGRID; 7372; 7.
DR   IntAct; Q9LV58; 6.
DR   STRING; 3702.AT3G24500.1; -.
DR   PaxDb; Q9LV58; -.
DR   PRIDE; Q9LV58; -.
DR   ProteomicsDB; 238692; -. [Q9LV58-1]
DR   EnsemblPlants; AT3G24500.1; AT3G24500.1; AT3G24500. [Q9LV58-1]
DR   GeneID; 822041; -.
DR   Gramene; AT3G24500.1; AT3G24500.1; AT3G24500. [Q9LV58-1]
DR   KEGG; ath:AT3G24500; -.
DR   Araport; AT3G24500; -.
DR   TAIR; locus:2091747; AT3G24500.
DR   eggNOG; KOG3398; Eukaryota.
DR   HOGENOM; CLU_112609_1_0_1; -.
DR   OMA; DWDPIVL; -.
DR   PhylomeDB; Q9LV58; -.
DR   PRO; PR:Q9LV58; -.
DR   Proteomes; UP000006548; Chromosome 3.
DR   ExpressionAtlas; Q9LV58; baseline and differential.
DR   Genevisible; Q9LV58; AT.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005730; C:nucleolus; IDA:TAIR.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; TAS:TAIR.
DR   GO; GO:0003713; F:transcription coactivator activity; IGI:TAIR.
DR   GO; GO:0071456; P:cellular response to hypoxia; HEP:TAIR.
DR   GO; GO:0009873; P:ethylene-activated signaling pathway; TAS:TAIR.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; TAS:TAIR.
DR   GO; GO:0009737; P:response to abscisic acid; IEP:TAIR.
DR   GO; GO:0009408; P:response to heat; IEP:TAIR.
DR   GO; GO:0009414; P:response to water deprivation; IEP:TAIR.
DR   CDD; cd00093; HTH_XRE; 1.
DR   Gene3D; 1.10.260.40; -; 1.
DR   InterPro; IPR001387; Cro/C1-type_HTH.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   InterPro; IPR013729; MBF1_N.
DR   Pfam; PF01381; HTH_3; 1.
DR   Pfam; PF08523; MBF1; 1.
DR   SMART; SM00530; HTH_XRE; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
DR   PROSITE; PS50943; HTH_CROC1; 1.
PE   1: Evidence at protein level;
KW   Activator; Alternative splicing; Cytoplasm; DNA-binding; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..148
FT                   /note="Multiprotein-bridging factor 1c"
FT                   /id="PRO_0000325905"
FT   DOMAIN          91..145
FT                   /note="HTH cro/C1-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00257"
FT   DNA_BIND        102..121
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00257"
FT   CONFLICT        7
FT                   /note="G -> E (in Ref. 4; AAM62814)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   148 AA;  16403 MW;  2133CFDACF068837 CRC64;
     MPSRYPGAVT QDWEPVVLHK SKQKSQDLRD PKAVNAALRN GVAVQTVKKF DAGSNKKGKS
     TAVPVINTKK LEEETEPAAM DRVKAEVRLM IQKARLEKKM SQADLAKQIN ERTQVVQEYE
     NGKAVPNQAV LAKMEKVLGV KLRGKIGK
 
 
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