ID   MBF1_CANAL              Reviewed;         151 AA.
AC   Q5A940; A0A1D8PCE8;
DT   16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Multiprotein-bridging factor 1;
GN   Name=MBF1; OrderedLocusNames=CAALFM_C101060WA;
GN   ORFNames=CaO19.10804, CaO19.3294;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Transcriptional coactivator that stimulates transcriptional
CC       activity by bridging regulatory proteins and TBP, thereby recruiting
CC       TBP to promoters occupied by DNA-binding regulators. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MBF1 family. {ECO:0000305}.
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DR   EMBL; CP017623; AOW25802.1; -; Genomic_DNA.
DR   RefSeq; XP_718117.1; XM_713024.2.
DR   AlphaFoldDB; Q5A940; -.
DR   SMR; Q5A940; -.
DR   STRING; 237561.Q5A940; -.
DR   PRIDE; Q5A940; -.
DR   GeneID; 3640171; -.
DR   KEGG; cal:CAALFM_C101060WA; -.
DR   CGD; CAL0000194672; MBF1.
DR   VEuPathDB; FungiDB:C1_01060W_A; -.
DR   eggNOG; KOG3398; Eukaryota.
DR   HOGENOM; CLU_112609_0_1_1; -.
DR   InParanoid; Q5A940; -.
DR   OMA; NKAHQGT; -.
DR   OrthoDB; 1571466at2759; -.
DR   PRO; PR:Q5A940; -.
DR   Proteomes; UP000000559; Chromosome 1.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003713; F:transcription coactivator activity; IEA:EnsemblFungi.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:EnsemblFungi.
DR   CDD; cd00093; HTH_XRE; 1.
DR   Gene3D; 1.10.260.40; -; 1.
DR   InterPro; IPR001387; Cro/C1-type_HTH.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   InterPro; IPR013729; MBF1_N.
DR   Pfam; PF01381; HTH_3; 1.
DR   Pfam; PF08523; MBF1; 1.
DR   SMART; SM00530; HTH_XRE; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
DR   PROSITE; PS50943; HTH_CROC1; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..151
FT                   /note="Multiprotein-bridging factor 1"
FT                   /id="PRO_0000149803"
FT   DOMAIN          86..140
FT                   /note="HTH cro/C1-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00257"
FT   DNA_BIND        97..116
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00257"
FT   REGION          1..32
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   151 AA;  16292 MW;  828EB4ACBD49B48F CRC64;
     MSSDWDSVTI IGQKARVGGG GPRENVAKTS SQLNAARRAG LVVGTEKKYG TANTKSNPEG
     QRLTKLDATD DVVAVKKVDV SVGKAIQQAR QEKKLTQKEL ATKVNEKPNV INDYEAGRAI
     PNQQLLAKLE RALGVKLRGK NIGEPLFAKK K