MBF1_CRYNB
ID MBF1_CRYNB Reviewed; 150 AA.
AC P0CO31; Q55KQ9; Q5KAR7;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 25-MAY-2022, entry version 47.
DE RecName: Full=Multiprotein-bridging factor 1;
GN Name=MBF1; OrderedLocusNames=CNBJ2740;
OS Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)
OS (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=283643;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B-3501A;
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- FUNCTION: Transcriptional coactivator that stimulates transcriptional
CC activity by bridging regulatory proteins and TBP, thereby recruiting
CC TBP to promoters occupied by DNA-binding regulators. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the MBF1 family. {ECO:0000305}.
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DR EMBL; AAEY01000050; EAL18351.1; -; Genomic_DNA.
DR RefSeq; XP_772998.1; XM_767905.1.
DR AlphaFoldDB; P0CO31; -.
DR SMR; P0CO31; -.
DR EnsemblFungi; AAW45939; AAW45939; CNJ00750.
DR EnsemblFungi; EAL18351; EAL18351; CNBJ2740.
DR GeneID; 4938617; -.
DR KEGG; cnb:CNBJ2740; -.
DR VEuPathDB; FungiDB:CNBJ2740; -.
DR HOGENOM; CLU_112609_0_1_1; -.
DR Proteomes; UP000001435; Chromosome 10.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR CDD; cd00093; HTH_XRE; 1.
DR Gene3D; 1.10.260.40; -; 1.
DR InterPro; IPR001387; Cro/C1-type_HTH.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR InterPro; IPR013729; MBF1_N.
DR Pfam; PF01381; HTH_3; 1.
DR Pfam; PF08523; MBF1; 1.
DR SMART; SM00530; HTH_XRE; 1.
DR SUPFAM; SSF47413; SSF47413; 1.
DR PROSITE; PS50943; HTH_CROC1; 1.
PE 3: Inferred from homology;
KW Activator; DNA-binding; Transcription; Transcription regulation.
FT CHAIN 1..150
FT /note="Multiprotein-bridging factor 1"
FT /id="PRO_0000410120"
FT DOMAIN 84..137
FT /note="HTH cro/C1-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00257"
FT DNA_BIND 94..113
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00257"
FT REGION 36..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 51..68
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 150 AA; 15938 MW; 8362FA6E1EDF18E0 CRC64;
MSDWDKPTVI GFRQQKPTVA KGSTLNAAQR AGLVISSESK GAGQSKGPAD HQRIAKLDRD
DAPKPPEKVS ADVGKAVATA RMAIKNAEGK SMTQKELATS VNAKPQDIAD LESGRAVPDQ
ALLGKLERKL NVKLRGAKNL IGTPLHPKKK