MBF1_DEBHA
ID MBF1_DEBHA Reviewed; 150 AA.
AC Q6BXQ8;
DT 16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 25-MAY-2022, entry version 98.
DE RecName: Full=Multiprotein-bridging factor 1;
GN Name=MBF1; OrderedLocusNames=DEHA2B01012g;
OS Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX NCBI_TaxID=284592;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Transcriptional coactivator that stimulates transcriptional
CC activity by bridging regulatory proteins and TBP, thereby recruiting
CC TBP to promoters occupied by DNA-binding regulators. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the MBF1 family. {ECO:0000305}.
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DR EMBL; CR382134; CAG84996.1; -; Genomic_DNA.
DR RefSeq; XP_457011.1; XM_457011.1.
DR AlphaFoldDB; Q6BXQ8; -.
DR SMR; Q6BXQ8; -.
DR STRING; 4959.XP_457011.1; -.
DR EnsemblFungi; CAG84996; CAG84996; DEHA2B01012g.
DR GeneID; 2913754; -.
DR KEGG; dha:DEHA2B01012g; -.
DR VEuPathDB; FungiDB:DEHA2B01012g; -.
DR eggNOG; KOG3398; Eukaryota.
DR HOGENOM; CLU_112609_0_1_1; -.
DR InParanoid; Q6BXQ8; -.
DR OMA; NKAHQGT; -.
DR OrthoDB; 1571466at2759; -.
DR Proteomes; UP000000599; Chromosome B.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR CDD; cd00093; HTH_XRE; 1.
DR Gene3D; 1.10.260.40; -; 1.
DR InterPro; IPR001387; Cro/C1-type_HTH.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR InterPro; IPR013729; MBF1_N.
DR Pfam; PF01381; HTH_3; 1.
DR Pfam; PF08523; MBF1; 1.
DR SMART; SM00530; HTH_XRE; 1.
DR SUPFAM; SSF47413; SSF47413; 1.
DR PROSITE; PS50943; HTH_CROC1; 1.
PE 3: Inferred from homology;
KW Activator; DNA-binding; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..150
FT /note="Multiprotein-bridging factor 1"
FT /id="PRO_0000149806"
FT DOMAIN 85..139
FT /note="HTH cro/C1-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00257"
FT DNA_BIND 96..115
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00257"
FT REGION 32..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 44..59
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 150 AA; 16348 MW; E9D004783297C89E CRC64;
MSDWDSVTII GQKARIGGGG PRQNVAKTQA ELNAARRSGN VVGTEKKYGS TNTKSNPEGQ
RLTKLDAVDD VVPTKKLDMN VGKAIQQARQ EKKLTQKDLA TKINEKPNVI NDYEAGRAVP
NQQLLGKLER ALGVKLRGKN IGEPLFAKKK
