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MBI1_NEUCR
ID   MBI1_NEUCR              Reviewed;         448 AA.
AC   Q35127; M1RM74;
DT   14-DEC-2011, integrated into UniProtKB/Swiss-Prot.
DT   14-DEC-2011, sequence version 2.
DT   25-MAY-2022, entry version 112.
DE   RecName: Full=Probable intron-encoded endonuclease bI1;
DE   Contains:
DE     RecName: Full=Truncated non-functional cytochrome b;
DE   Contains:
DE     RecName: Full=Intron-encoded endonuclease bI1;
DE              EC=3.1.-.-;
DE   Flags: Precursor;
GN   Name=bI1; Synonyms=cobi1; ORFNames=NCU16014;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OG   Mitochondrion.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Adiopodoume-1 / FGSC 430, and
RC   ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=2963999; DOI=10.1093/nar/16.3.1125;
RA   Collins R.A., Reynolds C.A., Olive J.;
RT   "The self-splicing intron in the Neurospora apocytochrome b gene contains a
RT   long reading frame in frame with the upstream exon.";
RL   Nucleic Acids Res. 16:1125-1134(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RA   Kennell J.C., Collins R.A., Griffiths A.J.F., Nargang F.E.;
RT   "Mitochondrial genetics of Neurospora.";
RL   (In) Kueck U. (eds.);
RL   The Mycota II, Genetics and Biotechnology (2nd edition), pp.95-112,
RL   Springer-Verlag, Berlin-Heidelberg (2004).
CC   -!- FUNCTION: Mitochondrial DNA endonuclease involved in intron homing.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- PTM: The mature protein may arise from proteolytic cleavage of an in-
CC       frame translation of cob exon 1 plus intron 1, containing the bI1 open
CC       reading frame.
CC   -!- SIMILARITY: To endonucleases of group I introns of fungi and phage.
CC       {ECO:0000305}.
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DR   EMBL; X06884; CAA30000.1; -; Genomic_DNA.
DR   EMBL; KC683708; AGG16004.1; -; Genomic_DNA.
DR   PIR; S03127; S03127.
DR   RefSeq; YP_009126716.1; NC_026614.1.
DR   AlphaFoldDB; Q35127; -.
DR   SMR; Q35127; -.
DR   EnsemblFungi; AGG16004; AGG16004; NCU16014.
DR   GeneID; 23681568; -.
DR   KEGG; ncr:NCU16014; -.
DR   VEuPathDB; FungiDB:NCU16014; -.
DR   InParanoid; Q35127; -.
DR   Proteomes; UP000001805; Mitochondrion.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0006314; P:intron homing; IEA:UniProtKB-KW.
DR   CDD; cd00284; Cytochrome_b_N; 1.
DR   Gene3D; 1.20.810.10; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   InterPro; IPR005797; Cyt_b/b6_N.
DR   InterPro; IPR027387; Cytb/b6-like_sf.
DR   InterPro; IPR016174; Di-haem_cyt_TM.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR006350; Intron_endoG1.
DR   InterPro; IPR003647; Intron_nuc_1_rpt.
DR   InterPro; IPR010896; NUMOD1.
DR   InterPro; IPR003611; NUMOD3.
DR   Pfam; PF00033; Cytochrome_B; 1.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF07453; NUMOD1; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00497; IENR1; 1.
DR   SMART; SM00496; IENR2; 2.
DR   SUPFAM; SSF81342; SSF81342; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR01453; grpIintron_endo; 1.
DR   PROSITE; PS51002; CYTB_NTER; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
PE   3: Inferred from homology;
KW   Endonuclease; Hydrolase; Intron homing; Membrane; Mitochondrion;
KW   Mitochondrion inner membrane; Nuclease; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..?
FT                   /note="Truncated non-functional cytochrome b"
FT                   /id="PRO_0000414731"
FT   CHAIN           ?..448
FT                   /note="Intron-encoded endonuclease bI1"
FT                   /id="PRO_0000414732"
FT   TRANSMEM        32..52
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00968"
FT   TRANSMEM        86..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00968"
FT   TRANSMEM        112..132
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00968"
FT   DOMAIN          230..321
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00977"
FT   REGION          1..132
FT                   /note="cob exon 1 encoded"
FT   REGION          133..448
FT                   /note="cob intron 1 encoded"
FT   VARIANT         221
FT                   /note="W -> R (in strain: FGSC 430)"
FT   VARIANT         362
FT                   /note="F -> L (in strain: FGSC 430)"
SQ   SEQUENCE   448 AA;  51648 MW;  249CDD7EBD11AB97 CRC64;
     MRLLKSHPLL KLVNSYLIDA SQPSNISYLW NFGSLLACCL IIQIVTGVTL AMHYSPNVLE
     AFNSIEHIMR DVNNGWLVRY LHSNTASAFF FLVYLHIGRG MYYGSYRAPR TLVWAIGTVI
     LILMMATAFL GYQHSPKWFD ISNKGSISNK GNITNSLPPL LQRWGGRINK RLFNKNLVKR
     GYCTSSSLNS PEMSERLQTI INELGINPVY VYEDLNQPSS WKQILHDTRD LSGVYMIINK
     TTKDYYIGSA SNNRFYTRFC NHVIHFTGSK IVKLAIKKYE LKNFAFVILD LYPNVVTKEN
     NKELLDLEDK YLKLLVPNYN ILTEAGSSFG YKHTEIDRQK MKDLYSDARR EKIGSLNRGK
     KFSPETIEKI REKALTRPPM SEETKIKCIA NTRPVVLYNL NRTIYGKYST ILEAANAINC
     NEKTIRRALQ TEKKLVKRQW IVEDFSDK
 
 
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