MBI3_NEUCR
ID MBI3_NEUCR Reviewed; 477 AA.
AC P0CY43; M1QL64; P00162; Q35132;
DT 14-DEC-2011, integrated into UniProtKB/Swiss-Prot.
DT 14-DEC-2011, sequence version 1.
DT 25-MAY-2022, entry version 42.
DE RecName: Full=Cytochrome b mRNA maturase bI3;
GN Name=bI3; Synonyms=cobi3; ORFNames=NCU16015;
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OG Mitochondrion.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=10872314; DOI=10.1002/j.1460-2075.1983.tb01575.x;
RA Helmer-Citterich M., Morelli G., Macino G.;
RT "Nucleotide sequence and intron structure of the apocytochrome b gene of
RT Neurospora crassa mitochondria.";
RL EMBO J. 2:1235-1242(1983).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RA Kennell J.C., Collins R.A., Griffiths A.J.F., Nargang F.E.;
RT "Mitochondrial genetics of Neurospora.";
RL (In) Kueck U. (eds.);
RL The Mycota II, Genetics and Biotechnology (2nd edition), pp.95-112,
RL Springer-Verlag, Berlin-Heidelberg (2004).
CC -!- FUNCTION: Mitochondrial mRNA maturase required for splicing of intron 3
CC of the cytochrome b (cob) gene, containing its own coding sequence.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305};
CC Multi-pass membrane protein {ECO:0000305}.
CC -!- MISCELLANEOUS: Encoded from partially processed cob mRNA that
CC terminates with the in-frame coding sequence of the third intron.
CC -!- SIMILARITY: In the N-terminal section; belongs to the cytochrome b
CC family. {ECO:0000305}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the LAGLIDADG
CC endonuclease family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA31960.2; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR EMBL; M37324; AAA31960.2; ALT_TERM; Genomic_DNA.
DR EMBL; KC683708; AGG16003.1; -; Genomic_DNA.
DR PIR; A00158; CBNC.
DR RefSeq; YP_009126715.1; NC_026614.1.
DR AlphaFoldDB; P0CY43; -.
DR SMR; P0CY43; -.
DR EnsemblFungi; AGG16003; AGG16003; NCU16015.
DR GeneID; 23681567; -.
DR KEGG; ncr:NCU16015; -.
DR VEuPathDB; FungiDB:NCU16015; -.
DR InParanoid; P0CY43; -.
DR Proteomes; UP000001805; Mitochondrion.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0009055; F:electron transfer activity; IEA:InterPro.
DR GO; GO:0004519; F:endonuclease activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0022904; P:respiratory electron transport chain; IEA:InterPro.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR CDD; cd00284; Cytochrome_b_N; 1.
DR Gene3D; 1.20.810.10; -; 1.
DR Gene3D; 3.10.28.10; -; 2.
DR InterPro; IPR005797; Cyt_b/b6_N.
DR InterPro; IPR027387; Cytb/b6-like_sf.
DR InterPro; IPR016174; Di-haem_cyt_TM.
DR InterPro; IPR027434; Homing_endonucl.
DR InterPro; IPR004860; LAGLIDADG_2.
DR Pfam; PF00033; Cytochrome_B; 1.
DR Pfam; PF00961; LAGLIDADG_1; 1.
DR SUPFAM; SSF55608; SSF55608; 2.
DR SUPFAM; SSF81342; SSF81342; 1.
DR PROSITE; PS51002; CYTB_NTER; 1.
PE 3: Inferred from homology;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; mRNA processing;
KW mRNA splicing; Reference proteome; RNA-binding; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..477
FT /note="Cytochrome b mRNA maturase bI3"
FT /id="PRO_0000414740"
FT TRANSMEM 32..52
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00968"
FT TRANSMEM 86..106
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00968"
FT TRANSMEM 113..133
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00968"
FT TRANSMEM 142..162
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00968"
FT TRANSMEM 166..186
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00968"
FT REGION 1..163
FT /note="Cytochrome b"
FT REGION 164..477
FT /note="Maturase"
FT CONFLICT 176
FT /note="I -> T (in Ref. 1; AAA31960)"
FT /evidence="ECO:0000305"
FT CONFLICT 201
FT /note="T -> M (in Ref. 1; AAA31960)"
FT /evidence="ECO:0000305"
FT CONFLICT 272
FT /note="E -> EYIHSILE (in Ref. 1; AAA31960)"
FT /evidence="ECO:0000305"
FT CONFLICT 307..319
FT /note="Missing (in Ref. 1; AAA31960)"
FT /evidence="ECO:0000305"
FT CONFLICT 331
FT /note="M -> I (in Ref. 1; AAA31960)"
FT /evidence="ECO:0000305"
FT CONFLICT 337
FT /note="D -> N (in Ref. 1; AAA31960)"
FT /evidence="ECO:0000305"
FT CONFLICT 340
FT /note="M -> I (in Ref. 1; AAA31960)"
FT /evidence="ECO:0000305"
FT CONFLICT 348..351
FT /note="TPAV -> APTI (in Ref. 1; AAA31960)"
FT /evidence="ECO:0000305"
FT CONFLICT 362
FT /note="T -> A (in Ref. 1; AAA31960)"
FT /evidence="ECO:0000305"
FT CONFLICT 376..378
FT /note="CSE -> YSK (in Ref. 1; AAA31960)"
FT /evidence="ECO:0000305"
FT CONFLICT 388..390
FT /note="DGC -> NSY (in Ref. 1; AAA31960)"
FT /evidence="ECO:0000305"
FT CONFLICT 408
FT /note="M -> I (in Ref. 1; AAA31960)"
FT /evidence="ECO:0000305"
FT CONFLICT 425..426
FT /note="GV -> SI (in Ref. 1; AAA31960)"
FT /evidence="ECO:0000305"
FT CONFLICT 431
FT /note="D -> N (in Ref. 1; AAA31960)"
FT /evidence="ECO:0000305"
FT CONFLICT 476
FT /note="A -> V (in Ref. 1; AAA31960)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 477 AA; 54555 MW; 5FEAB934391966F7 CRC64;
MRLLKSHPLL KLVNSYLIDA SQPSNISYLW NFGSLLACCL IIQIVTGVTL AMHYSPNVLE
AFNSIEHIMR DVNNGWLVRY LHSNTASAFF FLVYLHIGRG MYYGSYRAPR TLVWAIGTVI
LILMMATAFL GYVLPYGQMS LWGATVITNL ISAIPWIGQD IVESKIITLI INLSFIAILF
SIVVVYYYIL LHVNFSSNLP TIGVIHQNAL KKSNKALRLD KQEYISIPSS FLAFLAGLVD
GDGYIQVTKT SKGFIAIKLV ISLHLEDLSI LEYIHSVLKI GKINIYKDLR SPTCKLVINK
TDLQEILFPL LMYNKIFFLT NTRADQFNLA MYIFKNDIKM YNQIPDNTPA VFEIPKNPID
YTLLPFFKNW IVGFTCSEGS FFIKSNNDGC FQLKQRIHTN LFEAFKLMFN TNRKIDTTNN
FNQFGVSSKS DIQKVINFFS FSGLHPLVGL KYIQYIKWLN NLRESLRYST LNYPDAK
