ID   MBIA_ECO57              Reviewed;         171 AA.
AC   Q8XA70; Q7AHU6;
DT   07-JUN-2017, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2017, sequence version 2.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Uncharacterized protein MbiA {ECO:0000305};
DE   AltName: Full=Modifier of biofilm {ECO:0000303|PubMed:24111745};
GN   Name=mbiA {ECO:0000303|PubMed:24111745};
GN   Synonyms=htgA {ECO:0000312|EMBL:AAG54312.1};
GN   OrderedLocusNames=ECs0011 {ECO:0000312|EMBL:BAB33435.1},
GN   Z0012 {ECO:0000312|EMBL:AAG54312.1};
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
RN   [3]
RP   DISRUPTION PHENOTYPE.
RX   PubMed=24111745; DOI=10.1111/1574-6968.12288;
RA   Fellner L., Bechtel N., Witting M.A., Simon S., Schmitt-Kopplin P.,
RA   Keim D., Scherer S., Neuhaus K.;
RT   "Phenotype of htgA (mbiA), a recently evolved orphan gene of Escherichia
RT   coli and Shigella, completely overlapping in antisense to yaaW.";
RL   FEMS Microbiol. Lett. 350:57-64(2014).
CC   -!- DISRUPTION PHENOTYPE: Strand-specific deletion mutant, which disrupts
CC       only mbiA, shows no difference in growth compared with wild-type strain
CC       at 37 degrees Celsius or after heat shock. Biofilm formation is
CC       increased at 37 degrees Celsius. {ECO:0000269|PubMed:24111745}.
CC   -!- CAUTION: This gene is encoded entirely within the yaaW gene on the
CC       opposite strand. Disruptions of one gene are also usually disruptions
CC       in the other. {ECO:0000250|UniProtKB:P28697}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAG54312.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC       Sequence=BAB33435.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AE005174; AAG54312.1; ALT_INIT; Genomic_DNA.
DR   EMBL; BA000007; BAB33435.1; ALT_INIT; Genomic_DNA.
DR   PIR; D85481; D85481.
DR   PIR; D90630; D90630.
DR   AlphaFoldDB; Q8XA70; -.
DR   EnsemblBacteria; AAG54312; AAG54312; Z0012.
DR   KEGG; ece:Z0012; -.
DR   HOGENOM; CLU_1537672_0_0_6; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..171
FT                   /note="Uncharacterized protein MbiA"
FT                   /id="PRO_0000440621"
SQ   SEQUENCE   171 AA;  18959 MW;  0D8719B3C372F800 CRC64;
     MRVSWLESRC DTPFANNLSF ISSGSSSSSS FTLASTACRN SCLCSSSIFF QVLRRNCSSN
     CCSISNVDIS LSAFSFNRFE TSSKMARYNL PCPRSLLAIL SPPKCCNSPA ISCQLRRCCS
     GCPSIDLNSS LRISTLERRV LPFSLWVSSR AKFANCSSLQ CWRKSRSESF R