ID   ARGP_PSEAE              Reviewed;         300 AA.
AC   Q9HW38;
DT   19-DEC-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=HTH-type transcriptional regulator ArgP {ECO:0000255|HAMAP-Rule:MF_00513};
GN   Name=argP {ECO:0000255|HAMAP-Rule:MF_00513}; Synonyms=iciA;
GN   OrderedLocusNames=PA4363;
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA   Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
CC   -!- FUNCTION: Controls the transcription of genes involved in arginine and
CC       lysine metabolism. {ECO:0000255|HAMAP-Rule:MF_00513}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_00513}.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; AE004091; AAG07751.1; -; Genomic_DNA.
DR   PIR; B83100; B83100.
DR   RefSeq; NP_253053.1; NC_002516.2.
DR   RefSeq; WP_003120877.1; NZ_QZGE01000004.1.
DR   AlphaFoldDB; Q9HW38; -.
DR   SMR; Q9HW38; -.
DR   STRING; 287.DR97_1539; -.
DR   PaxDb; Q9HW38; -.
DR   PRIDE; Q9HW38; -.
DR   EnsemblBacteria; AAG07751; AAG07751; PA4363.
DR   GeneID; 881413; -.
DR   KEGG; pae:PA4363; -.
DR   PATRIC; fig|208964.12.peg.4570; -.
DR   PseudoCAP; PA4363; -.
DR   HOGENOM; CLU_063829_0_0_6; -.
DR   InParanoid; Q9HW38; -.
DR   OMA; WRNGGQL; -.
DR   PhylomeDB; Q9HW38; -.
DR   BioCyc; PAER208964:G1FZ6-4449-MON; -.
DR   Proteomes; UP000002438; Chromosome.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IDA:PseudoCAP.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 1.
DR   HAMAP; MF_00513; HTH_type_ArgP; 1.
DR   InterPro; IPR017685; ArgP.
DR   InterPro; IPR023490; ArgP_Gammaproteobact.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR03298; argP; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..300
FT                   /note="HTH-type transcriptional regulator ArgP"
FT                   /id="PRO_0000105645"
FT   DOMAIN          4..60
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00513"
FT   DNA_BIND        21..40
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00513"
SQ   SEQUENCE   300 AA;  32451 MW;  BFC7F298E51CFBE9 CRC64;
     MILFDYKLLA ALAAVVEQGG FERAAQALGL SQSAVSQRIK LLEARVGQPV LVRETPPHPT
     DLGRRLLNHV QQVRLLEGDL QRWVPNLDEG GAPERLRIAL NADSLATWWA AAVGDFCAER
     RVLLDLVVED QEVGLKRMRA GEVAGCVCGS ARPVAGARSL LLGAMRYRGL ASPDFIARHF
     PRGVEAAALA GVPAIVFGPD DLLQHRFLKD LGVEGGFIHH LCPSSEGFVR LTAGGLGWGL
     VPERQVQGEL ARGELVELLP GQVIDVPLYW HYWRNGGELL ASLTEHLLAR AGDGLVRVSG