ID   MBL_BACC1               Reviewed;         333 AA.
AC   P32444;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1993, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=Cell shape-determining protein Mbl {ECO:0000305};
GN   Name=mbl; OrderedLocusNames=BCE_5404;
OS   Bacillus cereus (strain ATCC 10987 / NRS 248).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=222523;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1452027; DOI=10.1016/0378-1119(92)90047-s;
RA   Narahara A., Naterstad K., Kristensen T., Lopez R., Bork P., Kolstoe A.-B.;
RT   "Cloning of a gene from Bacillus cereus with homology to the mreB gene from
RT   Escherichia coli.";
RL   Gene 122:181-185(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10217496; DOI=10.1099/13500872-145-3-621;
RA   Oekstad O.A., Hegna I.K., Lindbaeck T., Rishovd A.-L., Kolstoe A.-B.;
RT   "Genome organization is not conserved between Bacillus cereus and Bacillus
RT   subtilis.";
RL   Microbiology 145:621-631(1999).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10987 / NRS 248;
RX   PubMed=14960714; DOI=10.1093/nar/gkh258;
RA   Rasko D.A., Ravel J., Oekstad O.A., Helgason E., Cer R.Z., Jiang L.,
RA   Shores K.A., Fouts D.E., Tourasse N.J., Angiuoli S.V., Kolonay J.F.,
RA   Nelson W.C., Kolstoe A.-B., Fraser C.M., Read T.D.;
RT   "The genome sequence of Bacillus cereus ATCC 10987 reveals metabolic
RT   adaptations and a large plasmid related to Bacillus anthracis pXO1.";
RL   Nucleic Acids Res. 32:977-988(2004).
CC   -!- FUNCTION: Forms membrane-associated dynamic filaments that are
CC       essential for cell shape determination. Acts by regulating cell wall
CC       synthesis and cell elongation, and thus cell shape. A feedback loop
CC       between cell geometry and Mbl localization may maintain elongated cell
CC       shape by targeting cell wall growth to regions of negative cell wall
CC       curvature. {ECO:0000255|HAMAP-Rule:MF_02207}.
CC   -!- SUBUNIT: Forms polymers. {ECO:0000255|HAMAP-Rule:MF_02207}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_02207}.
CC       Note=Membrane-associated. {ECO:0000255|HAMAP-Rule:MF_02207}.
CC   -!- SIMILARITY: Belongs to the FtsA/MreB family. {ECO:0000255|HAMAP-
CC       Rule:MF_02207, ECO:0000305}.
CC   -!- CAUTION: Was originally thought to be MreB.
CC       {ECO:0000305|PubMed:1452027}.
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DR   EMBL; X62374; CAA44237.1; -; Genomic_DNA.
DR   EMBL; AJ010138; CAB40597.1; -; Genomic_DNA.
DR   EMBL; AE017194; AAS44304.1; -; Genomic_DNA.
DR   PIR; PN0441; PN0441.
DR   RefSeq; WP_000457987.1; NC_003909.8.
DR   AlphaFoldDB; P32444; -.
DR   SMR; P32444; -.
DR   EnsemblBacteria; AAS44304; AAS44304; BCE_5404.
DR   GeneID; 59156772; -.
DR   GeneID; 64200696; -.
DR   KEGG; bca:BCE_5404; -.
DR   HOGENOM; CLU_052037_0_0_9; -.
DR   OMA; MDIFQPS; -.
DR   Proteomes; UP000002527; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0000902; P:cell morphogenesis; IEA:InterPro.
DR   GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-UniRule.
DR   CDD; cd10225; MreB_like; 1.
DR   HAMAP; MF_02207; MreB; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR004753; MreB.
DR   PRINTS; PR01652; SHAPEPROTEIN.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   TIGRFAMs; TIGR00904; mreB; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell shape; Cytoplasm; Nucleotide-binding.
FT   CHAIN           1..333
FT                   /note="Cell shape-determining protein Mbl"
FT                   /id="PRO_0000062756"
FT   BINDING         12..14
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02207"
FT   BINDING         156..158
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02207"
FT   BINDING         204..207
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02207"
FT   BINDING         284..287
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02207"
SQ   SEQUENCE   333 AA;  35834 MW;  7B0D8F6FDBE1B24D CRC64;
     MFARDIGIDL GTANVLIHVK GKGIVLNEPS VVAIDRNTGK VLAVGEEARS MVGRTPGNIV
     AIRPLKDGVI ADFEITEAML KYFINKLDVK SFFSKPRILI CCPTNITSVE QKAIREAAER
     SGGKTVFLEE EPKVAAVGAG MEIFQPSGNM VVDIGGGTTD IAVLSMGDIV TSSSIKMAGD
     KFDMEILNYI KRKYKLLIGE RTSEDIKIKV GTVFPGARSE ELEIRGRDMV TGLPRTITVC
     SEEITEALKE NAAVIVQAAK GVLERTPPEL SADIIDRGVI LTGGGALLHG IDMLLAEELK
     VPVLIAENPM HCVAVGTGIM LENIDRLPKR ALR