ID   MBL_CAEBR               Reviewed;         299 AA.
AC   A8XND8;
DT   13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Muscleblind-like protein {ECO:0000250|UniProtKB:Q94250};
GN   Name=mbl-1 {ECO:0000312|EMBL:CAP34369.2}; ORFNames=CBG15968;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1] {ECO:0000312|EMBL:CAP34369.2}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Binds to RNA with repeat sequences CUG and CCUG.
CC       {ECO:0000250|UniProtKB:Q94250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O16011}.
CC   -!- SIMILARITY: Belongs to the muscleblind family. {ECO:0000255}.
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DR   EMBL; HE600995; CAP34369.2; -; Genomic_DNA.
DR   AlphaFoldDB; A8XND8; -.
DR   SMR; A8XND8; -.
DR   STRING; 6238.CBG15968; -.
DR   WormBase; CBG15968a; CBP40670; WBGene00036057; Cbr-mbl-1.
DR   eggNOG; KOG2494; Eukaryota.
DR   HOGENOM; CLU_053536_2_0_1; -.
DR   InParanoid; A8XND8; -.
DR   OMA; CEYMQPP; -.
DR   OrthoDB; 1204325at2759; -.
DR   Proteomes; UP000008549; Chromosome X.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; IBA:GO_Central.
DR   InterPro; IPR000571; Znf_CCCH.
DR   Pfam; PF00642; zf-CCCH; 1.
DR   SMART; SM00356; ZnF_C3H1; 2.
DR   PROSITE; PS50103; ZF_C3H1; 2.
PE   3: Inferred from homology;
KW   Metal-binding; Nucleus; Reference proteome; Repeat; RNA-binding; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..299
FT                   /note="Muscleblind-like protein"
FT                   /id="PRO_0000395432"
FT   ZN_FING         38..66
FT                   /note="C3H1-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT   ZN_FING         72..100
FT                   /note="C3H1-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
SQ   SEQUENCE   299 AA;  32480 MW;  2594C6C22899B173 CRC64;
     MFDENSNAAG TTPVASSLAA TPNANLMSQV FNVKDSRWLQ VEVCREFLRG QCARSDQECK
     FAHPPPNVDV QQGRVTACYD SIKGRCTREN PKCKYLHPPQ HIKDQLLING RNHLALKNLL
     SAQINQGGNQ MINPMLALQQ QAAAVNLLPN TQMYPQYYNG MMYQQVLPDP YAAAAQQLQT
     AALLGNVGGL LSAQSAAAAL VANSSTQPPT PSPLLRLQRK RALEEDTSNG NDRTAAAHTQ
     LLSLAAGAVP VKRPALDKNG AMLFSPAAPQ TPQFNPYLLQ TLQGYVPTVS CEYMQPPPF