MBL_CAEEL
ID MBL_CAEEL Reviewed; 324 AA.
AC Q94250; B3WFU7; B3WFU8;
DT 02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 2.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Muscleblind-like protein;
DE Short=CeMBL;
GN Name=mbl-1; ORFNames=K02H8.1;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP IDENTIFICATION.
RX PubMed=9334280; DOI=10.1242/dev.124.21.4321;
RA Begemann G., Paricio N., Artero R., Kiss I., Perez-Alonso M., Mlodzik M.;
RT "Muscleblind, a gene required for photoreceptor differentiation in
RT Drosophila, encodes novel nuclear Cys3His-type zinc-finger-containing
RT proteins.";
RL Development 124:4321-4331(1997).
RN [3]
RP FUNCTION, RNA-BINDING, TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
RX PubMed=19021294; DOI=10.1002/jnr.21942;
RA Sasagawa N., Ohno E., Kino Y., Watanabe Y., Ishiura S.;
RT "Identification of Caenorhabditis elegans K02H8.1 (CeMBL), a functional
RT ortholog of mammalian MBNL proteins.";
RL J. Neurosci. Res. 87:1090-1097(2009).
CC -!- FUNCTION: Binds to RNA with repeat sequences 5'-CUG-3' and 5'-CCUG-3'.
CC {ECO:0000269|PubMed:19021294}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=a;
CC IsoId=Q94250-1; Sequence=Displayed;
CC Name=b;
CC IsoId=Q94250-2; Sequence=VSP_039465;
CC Name=c;
CC IsoId=Q94250-3; Sequence=VSP_039466;
CC -!- TISSUE SPECIFICITY: Expressed in neurons around the pharynx.
CC {ECO:0000269|PubMed:19021294}.
CC -!- DISRUPTION PHENOTYPE: Reduced lifespan. {ECO:0000269|PubMed:19021294}.
CC -!- SIMILARITY: Belongs to the muscleblind family. {ECO:0000305}.
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DR EMBL; FO081289; CCD70500.1; -; Genomic_DNA.
DR EMBL; FO081289; CCD70501.1; -; Genomic_DNA.
DR EMBL; FO081289; CCD70502.1; -; Genomic_DNA.
DR PIR; T29715; T29715.
DR RefSeq; NP_001129931.1; NM_001136459.1. [Q94250-2]
DR RefSeq; NP_001129932.1; NM_001136460.1. [Q94250-3]
DR RefSeq; NP_001257281.1; NM_001270352.1. [Q94250-1]
DR AlphaFoldDB; Q94250; -.
DR SMR; Q94250; -.
DR STRING; 6239.K02H8.1a; -.
DR EPD; Q94250; -.
DR PaxDb; Q94250; -.
DR EnsemblMetazoa; K02H8.1a.1; K02H8.1a.1; WBGene00019347. [Q94250-1]
DR EnsemblMetazoa; K02H8.1a.2; K02H8.1a.2; WBGene00019347. [Q94250-1]
DR EnsemblMetazoa; K02H8.1b.1; K02H8.1b.1; WBGene00019347. [Q94250-2]
DR EnsemblMetazoa; K02H8.1c.1; K02H8.1c.1; WBGene00019347. [Q94250-3]
DR EnsemblMetazoa; K02H8.1c.2; K02H8.1c.2; WBGene00019347. [Q94250-3]
DR EnsemblMetazoa; K02H8.1c.3; K02H8.1c.3; WBGene00019347. [Q94250-3]
DR GeneID; 186912; -.
DR UCSC; K02H8.1; c. elegans. [Q94250-1]
DR CTD; 186912; -.
DR WormBase; K02H8.1a; CE39946; WBGene00019347; mbl-1. [Q94250-1]
DR WormBase; K02H8.1b; CE42747; WBGene00019347; mbl-1. [Q94250-2]
DR WormBase; K02H8.1c; CE42814; WBGene00019347; mbl-1. [Q94250-3]
DR eggNOG; KOG2494; Eukaryota.
DR GeneTree; ENSGT00950000182897; -.
DR InParanoid; Q94250; -.
DR OMA; CEYMQPP; -.
DR OrthoDB; 1204325at2759; -.
DR PhylomeDB; Q94250; -.
DR PRO; PR:Q94250; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00019347; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR ExpressionAtlas; Q94250; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; IBA:GO_Central.
DR InterPro; IPR000571; Znf_CCCH.
DR SMART; SM00356; ZnF_C3H1; 2.
DR PROSITE; PS50103; ZF_C3H1; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Metal-binding; Nucleus; Reference proteome; Repeat;
KW RNA-binding; Zinc; Zinc-finger.
FT CHAIN 1..324
FT /note="Muscleblind-like protein"
FT /id="PRO_0000089182"
FT ZN_FING 38..66
FT /note="C3H1-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT ZN_FING 72..100
FT /note="C3H1-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT VAR_SEQ 179..271
FT /note="Missing (in isoform c)"
FT /evidence="ECO:0000305"
FT /id="VSP_039466"
FT VAR_SEQ 179..196
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_039465"
SQ SEQUENCE 324 AA; 35234 MW; B714B65CC6B32AFB CRC64;
MFDENSNAAG TTPVASSLAA TPNANLVSQV FNVKDSRWLQ VEVCREFLRG QCARSDQECK
FAHPPPNVDV QQGRVTACYD SIKGRCTREN PKCKYLHPPQ HIKDQLLING RNHLALKNLL
SAQLNQTGTP MVNPMMALQQ QAAAVNLIPN TPIYPPYYNG MMYPQVLQDP YTAAAVNQVL
DSNQEYHSPP TDKKNQQLQT AALLGNVGGL LSAQSAAAFM ANSSAAAAAA QQTPSPLLRL
QRKRALEEEN TNGNDMTSAA AAHTQLLSLA AGAVPMKRPT LDKNGAMLYS PVAQQAQQFN
PYLLQTLQGY VPAVSCEYMQ PPPF
