MBN2A_TAKRU
ID MBN2A_TAKRU Reviewed; 351 AA.
AC Q6Q2B2;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 72.
DE RecName: Full=Muscleblind-like protein 2a;
DE AltName: Full=Tmbnl2a;
GN Name=mbnl2a;
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Myotomal muscle;
RX PubMed=17157048; DOI=10.1016/j.cbpb.2006.10.100;
RA Fernandes J.M.O., Kinghorn J.R., Johnston I.A.;
RT "Characterization of two paralogous muscleblind-like genes from the tiger
RT pufferfish (Takifugu rubripes).";
RL Comp. Biochem. Physiol. 146B:180-186(2007).
CC -!- FUNCTION: Involved in pre-mRNA alternative splicing regulation. RNA-
CC binding protein that binds to 5'ACACCC-3' core sequence (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in fast and slow myotomal muscle, heart,
CC liver, skin, brain and testis. {ECO:0000269|PubMed:17157048}.
CC -!- SIMILARITY: Belongs to the muscleblind family. {ECO:0000305}.
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DR EMBL; AY566276; AAS84613.1; -; mRNA.
DR RefSeq; NP_001027847.1; NM_001032675.1.
DR RefSeq; XP_011604364.1; XM_011606062.1.
DR AlphaFoldDB; Q6Q2B2; -.
DR SMR; Q6Q2B2; -.
DR STRING; 31033.ENSTRUP00000025745; -.
DR GeneID; 446045; -.
DR KEGG; tru:446045; -.
DR CTD; 446045; -.
DR eggNOG; KOG2494; Eukaryota.
DR InParanoid; Q6Q2B2; -.
DR Proteomes; UP000005226; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR InterPro; IPR000571; Znf_CCCH.
DR Pfam; PF00642; zf-CCCH; 2.
DR SMART; SM00356; ZnF_C3H1; 4.
DR PROSITE; PS50103; ZF_C3H1; 4.
PE 2: Evidence at transcript level;
KW Cytoplasm; Metal-binding; mRNA processing; mRNA splicing; Nucleus;
KW Reference proteome; Repeat; RNA-binding; Zinc; Zinc-finger.
FT CHAIN 1..351
FT /note="Muscleblind-like protein 2a"
FT /id="PRO_0000284140"
FT ZN_FING 13..41
FT /note="C3H1-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT ZN_FING 47..73
FT /note="C3H1-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT ZN_FING 177..205
FT /note="C3H1-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT ZN_FING 213..239
FT /note="C3H1-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
SQ SEQUENCE 351 AA; 38204 MW; 3BFD121CB5A67126 CRC64;
MALNIASIRD TKWLTLEVCR QFQRGTCSRS DEECKFAHPP KSCQVENGRV IACFDSLKGR
CTRENCKYLH PPAHLKTQLE INGRNNLIQQ KTAAAMLAQQ MQFMIPSTTM QHVQTFPVNQ
GLGSSAGLSY TPYLTPMSHS MGLVPTDILP STPVIVPGSP PVSVTAGSSS NQKLLRTDKL
EVCREFQRGN CARGETDCRF AHPSDSPMID TSDNTVTVCM DYIKSRCSRE KCKYFHPPAH
LQAKVKAAQH QANQTAVAAQ AAATAAAMTQ STAKAMKRPL EATVDLAFPH SGLQPLPKRP
ALEKSNGSSS LFNPSVLHYQ QALANAQLQQ PAFFPTGSVL CMTPASSLGR S