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MBN2A_TAKRU
ID   MBN2A_TAKRU             Reviewed;         351 AA.
AC   Q6Q2B2;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Muscleblind-like protein 2a;
DE   AltName: Full=Tmbnl2a;
GN   Name=mbnl2a;
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Myotomal muscle;
RX   PubMed=17157048; DOI=10.1016/j.cbpb.2006.10.100;
RA   Fernandes J.M.O., Kinghorn J.R., Johnston I.A.;
RT   "Characterization of two paralogous muscleblind-like genes from the tiger
RT   pufferfish (Takifugu rubripes).";
RL   Comp. Biochem. Physiol. 146B:180-186(2007).
CC   -!- FUNCTION: Involved in pre-mRNA alternative splicing regulation. RNA-
CC       binding protein that binds to 5'ACACCC-3' core sequence (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in fast and slow myotomal muscle, heart,
CC       liver, skin, brain and testis. {ECO:0000269|PubMed:17157048}.
CC   -!- SIMILARITY: Belongs to the muscleblind family. {ECO:0000305}.
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DR   EMBL; AY566276; AAS84613.1; -; mRNA.
DR   RefSeq; NP_001027847.1; NM_001032675.1.
DR   RefSeq; XP_011604364.1; XM_011606062.1.
DR   AlphaFoldDB; Q6Q2B2; -.
DR   SMR; Q6Q2B2; -.
DR   STRING; 31033.ENSTRUP00000025745; -.
DR   GeneID; 446045; -.
DR   KEGG; tru:446045; -.
DR   CTD; 446045; -.
DR   eggNOG; KOG2494; Eukaryota.
DR   InParanoid; Q6Q2B2; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   InterPro; IPR000571; Znf_CCCH.
DR   Pfam; PF00642; zf-CCCH; 2.
DR   SMART; SM00356; ZnF_C3H1; 4.
DR   PROSITE; PS50103; ZF_C3H1; 4.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Metal-binding; mRNA processing; mRNA splicing; Nucleus;
KW   Reference proteome; Repeat; RNA-binding; Zinc; Zinc-finger.
FT   CHAIN           1..351
FT                   /note="Muscleblind-like protein 2a"
FT                   /id="PRO_0000284140"
FT   ZN_FING         13..41
FT                   /note="C3H1-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT   ZN_FING         47..73
FT                   /note="C3H1-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT   ZN_FING         177..205
FT                   /note="C3H1-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT   ZN_FING         213..239
FT                   /note="C3H1-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
SQ   SEQUENCE   351 AA;  38204 MW;  3BFD121CB5A67126 CRC64;
     MALNIASIRD TKWLTLEVCR QFQRGTCSRS DEECKFAHPP KSCQVENGRV IACFDSLKGR
     CTRENCKYLH PPAHLKTQLE INGRNNLIQQ KTAAAMLAQQ MQFMIPSTTM QHVQTFPVNQ
     GLGSSAGLSY TPYLTPMSHS MGLVPTDILP STPVIVPGSP PVSVTAGSSS NQKLLRTDKL
     EVCREFQRGN CARGETDCRF AHPSDSPMID TSDNTVTVCM DYIKSRCSRE KCKYFHPPAH
     LQAKVKAAQH QANQTAVAAQ AAATAAAMTQ STAKAMKRPL EATVDLAFPH SGLQPLPKRP
     ALEKSNGSSS LFNPSVLHYQ QALANAQLQQ PAFFPTGSVL CMTPASSLGR S
 
 
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