MBNL1_CHICK
ID MBNL1_CHICK Reviewed; 369 AA.
AC Q5ZKW9;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=Muscleblind-like protein 1;
GN Name=MBNL1; ORFNames=RCJMB04_8n15;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- FUNCTION: Involved in pre-mRNA alternative splicing regulation. Binds
CC to CUG triplet repeat in RNA (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9NR56}. Cytoplasm
CC {ECO:0000250|UniProtKB:Q9NR56}. Cytoplasmic granule
CC {ECO:0000250|UniProtKB:Q9NR56}.
CC -!- SIMILARITY: Belongs to the muscleblind family. {ECO:0000305}.
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DR EMBL; AJ719965; CAG31624.1; -; mRNA.
DR RefSeq; NP_001026493.1; NM_001031322.3.
DR AlphaFoldDB; Q5ZKW9; -.
DR SMR; Q5ZKW9; -.
DR STRING; 9031.ENSGALP00000016852; -.
DR PaxDb; Q5ZKW9; -.
DR Ensembl; ENSGALT00000076947; ENSGALP00000054130; ENSGALG00000029190.
DR GeneID; 425033; -.
DR KEGG; gga:425033; -.
DR CTD; 4154; -.
DR VEuPathDB; HostDB:geneid_425033; -.
DR eggNOG; KOG2494; Eukaryota.
DR GeneTree; ENSGT00950000182897; -.
DR HOGENOM; CLU_053536_0_0_1; -.
DR InParanoid; Q5ZKW9; -.
DR PRO; PR:Q5ZKW9; -.
DR Proteomes; UP000000539; Chromosome 9.
DR Bgee; ENSGALG00000029190; Expressed in muscle tissue and 13 other tissues.
DR ExpressionAtlas; Q5ZKW9; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; IBA:GO_Central.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR InterPro; IPR000571; Znf_CCCH.
DR Pfam; PF00642; zf-CCCH; 1.
DR SMART; SM00356; ZnF_C3H1; 4.
DR PROSITE; PS50103; ZF_C3H1; 4.
PE 2: Evidence at transcript level;
KW Cytoplasm; Metal-binding; mRNA processing; mRNA splicing; Nucleus;
KW Reference proteome; Repeat; RNA-binding; Zinc; Zinc-finger.
FT CHAIN 1..369
FT /note="Muscleblind-like protein 1"
FT /id="PRO_0000274871"
FT ZN_FING 13..41
FT /note="C3H1-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT ZN_FING 47..73
FT /note="C3H1-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT ZN_FING 178..206
FT /note="C3H1-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT ZN_FING 214..240
FT /note="C3H1-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
SQ SEQUENCE 369 AA; 39670 MW; 0293DB3FC5D957CE CRC64;
MAVSVTPIRD TKWLTLEVCR EFQRGTCSRP DTECKFAHPS KSCQVENGRV IACFDSLKGR
CSRENCKYLH PPPHLKTQLE INGRNNLIQQ KNMAMLAQQM QLANAMMPGA PLQPVPMFSV
APSLATNASA AFNPYLGPVS PGLVPAEILP TAPMLVAGNP GVPVPAAAAA AAQKLMRTDR
LEVCREYQRG NCNRGENDCR FAHPADSAMI DTNDNTVTVC MDYIKGRCSR EKCKYFHPPA
HLQAKIKAAQ YQVNQAAAAQ AAATAAAMGI PQAVLPPLPK RPALEKTNGA TAVFNTGIFQ
YQQALANMQL QQHTAFLPPV PMVHGATPAT VSAATTSATS VPFAATATAN QIPIISAEHL
TSHKYVTQM