ID   MBNL3_TAKRU             Reviewed;         323 AA.
AC   Q56V19;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Muscleblind-like protein 3;
DE   AltName: Full=Tmbnl3;
GN   Name=mbnl3;
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Myotomal muscle;
RX   PubMed=17157048; DOI=10.1016/j.cbpb.2006.10.100;
RA   Fernandes J.M.O., Kinghorn J.R., Johnston I.A.;
RT   "Characterization of two paralogous muscleblind-like genes from the tiger
RT   pufferfish (Takifugu rubripes).";
RL   Comp. Biochem. Physiol. 146B:180-186(2007).
CC   -!- FUNCTION: Involved in pre-mRNA alternative splicing regulation. Could
CC       inhibit terminal muscle differentiation, acting at approximately the
CC       time of myogenin induction (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in fast and slow myotomal muscle, heart,
CC       liver, skin, brain and testis. {ECO:0000269|PubMed:17157048}.
CC   -!- SIMILARITY: Belongs to the muscleblind family. {ECO:0000305}.
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DR   EMBL; AY566277; AAT73198.1; -; mRNA.
DR   RefSeq; NP_001033092.1; NM_001038003.1.
DR   AlphaFoldDB; Q56V19; -.
DR   SMR; Q56V19; -.
DR   STRING; 31033.ENSTRUP00000032079; -.
DR   GeneID; 654324; -.
DR   KEGG; tru:654324; -.
DR   CTD; 55796; -.
DR   eggNOG; KOG2494; Eukaryota.
DR   InParanoid; Q56V19; -.
DR   OrthoDB; 1543798at2759; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   InterPro; IPR000571; Znf_CCCH.
DR   Pfam; PF00642; zf-CCCH; 2.
DR   SMART; SM00356; ZnF_C3H1; 4.
DR   PROSITE; PS50103; ZF_C3H1; 4.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Developmental protein; Metal-binding; mRNA processing;
KW   mRNA splicing; Nucleus; Reference proteome; Repeat; Zinc; Zinc-finger.
FT   CHAIN           1..323
FT                   /note="Muscleblind-like protein 3"
FT                   /id="PRO_0000284141"
FT   ZN_FING         13..41
FT                   /note="C3H1-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT   ZN_FING         47..73
FT                   /note="C3H1-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT   ZN_FING         177..205
FT                   /note="C3H1-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT   ZN_FING         213..239
FT                   /note="C3H1-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
SQ   SEQUENCE   323 AA;  35482 MW;  67B6589604806D17 CRC64;
     MAVNMTMGRD TKWLTLEVCR EFQRGTCSRS DAECKFAHPS RSCHVENGRV IACFDSLKGR
     CTRENCKYLH PPPHLKTQLE INGRNNLIQQ KAAAAMLAQQ MQFMLPGAQL QPITTFPMTH
     SLATSPSMAF SPYLNHMGPG MGLMPELLPS TPLLVPGSPT GLAAMSNGTS SPKHMRTDKL
     EVCREFQRGN CTRGESDCRY AHPLEAGMVD SSENSVIVCM DYIKGRCSRD KCKYFHPPAH
     LQARIKASQH QASQNTASAA LSPPAGTMQL LPKRPVLEKS NGAVAGIFNP SMFHYQQALA
     NMQLQQPAFI PTGEWCSGVV TLC