ID   MBP1_KLULA              Reviewed;         754 AA.
AC   P39679; Q6CPF0;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2004, sequence version 2.
DT   25-MAY-2022, entry version 136.
DE   RecName: Full=Transcription factor MBP1;
DE   AltName: Full=MBF subunit P120;
GN   Name=MBP1; OrderedLocusNames=KLLA0E05357g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8372350; DOI=10.1126/science.8372350;
RA   Koch C., Moll T., Neuberg M., Ahorn H., Nasmyth K.;
RT   "A role for the transcription factors Mbp1 and Swi4 in progression from G1
RT   to S phase.";
RL   Science 261:1551-1557(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Binds to MCB elements (Mlu I cell cycle box) found in the
CC       promoter of most DNA synthesis genes. Transcriptional activation by MBF
CC       has an important role in the transition from G1 to S phase. It may have
CC       a dual role in that it behaves as an activator of transcription at the
CC       G1-S boundary and as a repressor during other stages of the cell cycle.
CC   -!- SUBUNIT: MBF contains SWI6 and MBP1.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
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DR   EMBL; X74159; CAA52272.1; -; Genomic_DNA.
DR   EMBL; CR382125; CAG99276.1; -; Genomic_DNA.
DR   PIR; S37403; S37403.
DR   RefSeq; XP_454189.1; XM_454189.1.
DR   AlphaFoldDB; P39679; -.
DR   SMR; P39679; -.
DR   STRING; 28985.XP_454189.1; -.
DR   EnsemblFungi; CAG99276; CAG99276; KLLA0_E05413g.
DR   GeneID; 2894280; -.
DR   KEGG; kla:KLLA0_E05413g; -.
DR   eggNOG; KOG4177; Eukaryota.
DR   HOGENOM; CLU_009666_3_0_1; -.
DR   InParanoid; P39679; -.
DR   OMA; QRNARKC; -.
DR   Proteomes; UP000000598; Chromosome E.
DR   GO; GO:0030907; C:MBF transcription complex; IEA:EnsemblFungi.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:EnsemblFungi.
DR   GO; GO:0071931; P:positive regulation of transcription involved in G1/S transition of mitotic cell cycle; IEA:EnsemblFungi.
DR   Gene3D; 1.25.40.20; -; 1.
DR   Gene3D; 3.10.260.10; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR036887; HTH_APSES_sf.
DR   InterPro; IPR018004; KilA_N/APSES_HTH.
DR   InterPro; IPR029793; Mbp1/Res1/Res2.
DR   InterPro; IPR003163; Tscrpt_reg_HTH_APSES-type.
DR   PANTHER; PTHR43828:SF1; PTHR43828:SF1; 2.
DR   Pfam; PF00023; Ank; 1.
DR   Pfam; PF04383; KilA-N; 1.
DR   SMART; SM00248; ANK; 2.
DR   SMART; SM01252; KilA-N; 1.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   SUPFAM; SSF54616; SSF54616; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 2.
DR   PROSITE; PS51299; HTH_APSES; 1.
PE   4: Predicted;
KW   Activator; ANK repeat; DNA-binding; Nucleus; Reference proteome; Repeat;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..754
FT                   /note="Transcription factor MBP1"
FT                   /id="PRO_0000067061"
FT   DOMAIN          6..112
FT                   /note="HTH APSES-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00630"
FT   REPEAT          375..404
FT                   /note="ANK 1"
FT   REPEAT          493..522
FT                   /note="ANK 2"
FT   DNA_BIND        37..58
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00630"
FT   REGION          105..215
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          239..301
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        131..165
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        177..215
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        268..301
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        372
FT                   /note="I -> S (in Ref. 1; CAA52272)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   754 AA;  85029 MW;  937B17E2D2F27684 CRC64;
     MSSNQIYSAK YSGVDVYEFI HPTGSIMKRK ADNWVNATHI LKAAKFPKAK RTRILEKEVI
     TDTHEKVQGG FGKYQGTWIP LELASKLAEK FEVLDELKPL FDFTQQEGSA SPPQAPKHHH
     ASRSDSTRKK ATKSASVPSG KVSEKASSQQ QQPVSQQQQQ QPGSAPKRRG RPPRNKATVT
     LQRSQSEMVF PKPSIPSSSI QSTKLPSLQP QFGRSATSLS PIMDVKSPLD QASPQFKELD
     IEDGLSSDVE PNSIMGTKHE DNTHLMNTKD EPVSSSSSLP SSPSEFSQSV AFGSRSNMQT
     PLQLNGTTSM NMILPKFSSS QNGPSDSNQR ANEYLSKLVN YFISNDTQNE SEIPMELLNP
     PLHCSPFIDT WIDPEHHTAF HWACAMGTLP IVEALLKAGS SIRSLNNVGE TPLIRSSIFH
     NCYTKRTYPQ IFEILKDTVF DLDAKSRNVI HRIVSRKSHT PSAVYYLDVV LSKIKDFTPQ
     YRIDVLINQQ DNDGNSPLHY AATNKDDQFY QLLLQNGALT TVQNNSGMTP NGIISGRYSM
     DEITKGQRLD DPYEFNKMYP SQAATRTNRI IPEVINMMKE MANSYQNAYQ KRQNEVLQME
     RTVKSMKKTI TSVEMKLLEA LNLKETDNVD IVLNDRKEKI DELQRRIATD KRVLINRLEE
     GQVKLIRKFV DEETKNVEGK TTDGEESEDI EALLKELVLI QLKRKRKLNQ IIDVITDNSK
     VYKYRKMISQ GTDIDVSDVD ECLDVIYQTL SKEG