MBP2C_TOBAC
ID MBP2C_TOBAC Reviewed; 337 AA.
AC A0A1S3X835; Q8S556;
DT 30-AUG-2017, integrated into UniProtKB/Swiss-Prot.
DT 12-APR-2017, sequence version 1.
DT 25-MAY-2022, entry version 18.
DE RecName: Full=Protein MICROTUBULE BINDING PROTEIN 2C {ECO:0000303|PubMed:17965274};
DE Short=NtMBP2C {ECO:0000303|PubMed:17965274};
DE AltName: Full=Movement protein binding protein 2C {ECO:0000303|PubMed:17965274};
DE AltName: Full=TMV-MP30 binding protein 2C {ECO:0000303|PubMed:12913144};
GN Name=MBP2C {ECO:0000303|PubMed:17965274};
GN ORFNames=LOC107762219 {ECO:0000312|RefSeq:XP_016436046.1};
OS Nicotiana tabacum (Common tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4097;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, INTERACTION WITH TOBACCO
RP MOSAIC VIRUS MP, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RC STRAIN=cv. Samsun NN, and cv. Turkish;
RX PubMed=12913144; DOI=10.1104/pp.103.022269;
RA Kragler F., Curin M., Trutnyeva K., Gansch A., Waigmann E.;
RT "MPB2C, a microtubule-associated plant protein binds to and interferes with
RT cell-to-cell transport of tobacco mosaic virus movement protein.";
RL Plant Physiol. 132:1870-1883(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TN90;
RX PubMed=24807620; DOI=10.1038/ncomms4833;
RA Sierro N., Battey J.N., Ouadi S., Bakaher N., Bovet L., Willig A.,
RA Goepfert S., Peitsch M.C., Ivanov N.V.;
RT "The tobacco genome sequence and its comparison with those of tomato and
RT potato.";
RL Nat. Commun. 5:3833-3833(2014).
RN [3]
RP FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH KN-1 AND TOBACCO
RP MOSAIC VIRUS MP.
RX PubMed=17965274; DOI=10.1105/tpc.107.044354;
RA Winter N., Kollwig G., Zhang S., Kragler F.;
RT "MPB2C, a microtubule-associated protein, regulates non-cell-autonomy of
RT the homeodomain protein KNOTTED1.";
RL Plant Cell 19:3001-3018(2007).
CC -!- FUNCTION: Prevents homeodomain proteins (e.g. STM) association to
CC plasmodesmata and, consequently, cell-to-cell transport. Binds to RNA.
CC Alters KN1 RNA-binding capacity (PubMed:17965274). Regulates
CC cytoskeleton (e.g. actin) organization that determinates cell shape (By
CC similarity). Interferes with cell-to-cell transport of tobacco mosaic
CC virus movement protein (TMV-MP) by mediating its accumulation at
CC microtubules, thus interfering with cell-to-cell virus movement.
CC {ECO:0000250|UniProtKB:Q9LEZ4, ECO:0000269|PubMed:12913144,
CC ECO:0000269|PubMed:17965274}.
CC -!- SUBUNIT: Interacts with KN-1 (PubMed:17965274). Binds to tobacco mosaic
CC virus movement protein (TMV-MP) at microtubules (PubMed:12913144,
CC PubMed:17965274). {ECO:0000269|PubMed:12913144,
CC ECO:0000269|PubMed:17965274}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000269|PubMed:12913144}. Note=Microtubule-associated
CC (PubMed:12913144). Localized in cytosolic punctae when associated with
CC KN-1 (PubMed:17965274). {ECO:0000269|PubMed:12913144,
CC ECO:0000269|PubMed:17965274}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=A0A1S3X835-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A0A1S3X835-2; Sequence=VSP_059025;
CC -!- TISSUE SPECIFICITY: Constitutively expressed in leaves.
CC {ECO:0000269|PubMed:12913144}.
CC -!- SIMILARITY: Belongs to the microtubule binding protein 2C family.
CC {ECO:0000305}.
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DR EMBL; AF326729; AAL95696.1; -; mRNA.
DR RefSeq; NP_001311679.1; NM_001324750.1. [A0A1S3X835-2]
DR RefSeq; XP_016436046.1; XM_016580560.1. [A0A1S3X835-1]
DR AlphaFoldDB; A0A1S3X835; -.
DR SMR; A0A1S3X835; -.
DR STRING; 4097.A0A1S3X835; -.
DR GeneID; 107762219; -.
DR KEGG; nta:107762219; -.
DR OMA; NEMNVAN; -.
DR OrthoDB; 1151274at2759; -.
DR Proteomes; UP000084051; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0015630; C:microtubule cytoskeleton; IDA:UniProtKB.
DR GO; GO:0008017; F:microtubule binding; IDA:UniProtKB.
DR GO; GO:0003723; F:RNA binding; IDA:UniProtKB.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0051224; P:negative regulation of protein transport; IDA:UniProtKB.
DR GO; GO:0010497; P:plasmodesmata-mediated intercellular transport; IDA:UniProtKB.
DR GO; GO:0002230; P:positive regulation of defense response to virus by host; ISS:UniProtKB.
DR GO; GO:0051493; P:regulation of cytoskeleton organization; ISS:UniProtKB.
DR GO; GO:0046740; P:transport of virus in host, cell to cell; IDA:UniProtKB.
DR InterPro; IPR040289; MBP2C.
DR PANTHER; PTHR35502; PTHR35502; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Cytoplasm; Cytoskeleton;
KW Host-virus interaction; Plant defense; Reference proteome; RNA-binding.
FT CHAIN 1..337
FT /note="Protein MICROTUBULE BINDING PROTEIN 2C"
FT /id="PRO_0000441030"
FT REGION 80..147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 143..194
FT /evidence="ECO:0000255"
FT COILED 223..250
FT /evidence="ECO:0000255"
FT COILED 294..314
FT /evidence="ECO:0000255"
FT COMPBIAS 122..141
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..19
FT /note="MYKPQQQQQLFDLQDNNGA -> MAL (in isoform 2)"
FT /id="VSP_059025"
SQ SEQUENCE 337 AA; 37930 MW; 6DC0E597FD637C7A CRC64;
MYKPQQQQQL FDLQDNNGAA FDNGGTDPSC WLSHENEISR TDSSLSSSNV DPLLFNDLVQ
IVPLVQSLID RKEKSSFTRR GSMTYTKMPS RESLYKKTSE VKGRNAGQST ATKKHRDQNK
NVSSSQDGYA ENFSTPSSTS SLTEKDREEL MTLREKVEDL QKKLLEKDEL LKEAEILKNE
ITATNAELDE MKKDISEKDF LVKTTQVQLS DALVKLADKK AAVEKLEWEA MTSSKKVERL
QEDLDLLQGE ISSFIQFVHA LTGNDSRDSA EECNVIPYPW DQNVEIDKLN ERDLQKMEAA
REAYIAAVAA AKENPDEASL SAASTARSYL QSLVLRT
