ID   MBPHL_RAT               Reviewed;         355 AA.
AC   Q5PQM4;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 1.
DT   03-AUG-2022, entry version 123.
DE   RecName: Full=Myosin-binding protein H-like;
GN   Name=Mybphl;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-39, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903; DOI=10.1038/ncomms1871;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA   Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14 different rat
RT   organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
CC   -!- FUNCTION: Myosin-binding protein which plays a role in cardiac
CC       function. Seems to regulate conduction in the atria and ventricular
CC       conduction systems. {ECO:0000250|UniProtKB:A2RUH7}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere
CC       {ECO:0000250|UniProtKB:A2RUH7}.
CC   -!- SIMILARITY: Belongs to the immunoglobulin superfamily. MyBP family.
CC       {ECO:0000305}.
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DR   EMBL; BC087113; AAH87113.1; -; mRNA.
DR   RefSeq; NP_001014064.1; NM_001014042.1.
DR   RefSeq; XP_006233212.1; XM_006233150.3.
DR   RefSeq; XP_017446414.1; XM_017590925.1.
DR   AlphaFoldDB; Q5PQM4; -.
DR   SMR; Q5PQM4; -.
DR   STRING; 10116.ENSRNOP00000027099; -.
DR   iPTMnet; Q5PQM4; -.
DR   PhosphoSitePlus; Q5PQM4; -.
DR   PaxDb; Q5PQM4; -.
DR   Ensembl; ENSRNOT00000027099; ENSRNOP00000027099; ENSRNOG00000037082.
DR   GeneID; 310782; -.
DR   KEGG; rno:310782; -.
DR   UCSC; RGD:1310511; rat.
DR   CTD; 343263; -.
DR   RGD; 1310511; Mybphl.
DR   eggNOG; ENOG502QVIQ; Eukaryota.
DR   GeneTree; ENSGT00940000162165; -.
DR   HOGENOM; CLU_037185_0_0_1; -.
DR   InParanoid; Q5PQM4; -.
DR   OMA; GCALDTR; -.
DR   OrthoDB; 653839at2759; -.
DR   PhylomeDB; Q5PQM4; -.
DR   TreeFam; TF334735; -.
DR   PRO; PR:Q5PQM4; -.
DR   Proteomes; UP000002494; Chromosome 2.
DR   Bgee; ENSRNOG00000037082; Expressed in lung and 2 other tissues.
DR   Genevisible; Q5PQM4; RN.
DR   GO; GO:0036379; C:myofilament; ISS:UniProtKB.
DR   GO; GO:0030017; C:sarcomere; IEA:UniProtKB-SubCell.
DR   GO; GO:0001701; P:in utero embryonic development; ISO:RGD.
DR   CDD; cd00063; FN3; 1.
DR   Gene3D; 2.60.40.10; -; 3.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   Pfam; PF00041; fn3; 1.
DR   Pfam; PF07679; I-set; 2.
DR   SMART; SM00060; FN3; 1.
DR   SMART; SM00409; IG; 2.
DR   SMART; SM00408; IGc2; 2.
DR   SUPFAM; SSF48726; SSF48726; 2.
DR   SUPFAM; SSF49265; SSF49265; 1.
DR   PROSITE; PS50853; FN3; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Disulfide bond; Immunoglobulin domain; Methylation;
KW   Phosphoprotein; Reference proteome; Repeat.
FT   CHAIN           1..355
FT                   /note="Myosin-binding protein H-like"
FT                   /id="PRO_0000330021"
FT   DOMAIN          46..140
FT                   /note="Ig-like C2-type 1"
FT   DOMAIN          149..244
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT   DOMAIN          262..346
FT                   /note="Ig-like C2-type 2"
FT   REGION          1..43
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        28..42
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         39
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   MOD_RES         322
FT                   /note="Omega-N-methylarginine"
FT                   /evidence="ECO:0000250|UniProtKB:Q5FW53"
FT   DISULFID        283..334
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ   SEQUENCE   355 AA;  38924 MW;  9EB788821E73F681 CRC64;
     METATTLEIA SCSQRQVEEA ADPADAEGPQ TTRQQEAGSP SLQLLPSIEE HPKIWLPRAL
     RQTYIRKVGE TVNLLIPFQG KPKPQTIWTH NGSALDNSRV SVRNGEHDSI LFIREAQRTD
     SGCYQLCVQL GGLQATATIN ILVIEKPGPP QSIKLVDVWG ANATLEWTPP QDTGNTALLG
     YTVQKADKKS GLWFTVLERY HRTSCIVSDL IVGNSYAFRV FAENQCGLSD TAPVTADLAH
     IQKAATVYKA KGFAQRDLSE APKFTQPLAD CTTVTGYDTQ LFCCVRASPK PKIIWLKNKM
     DLQGNPKYRA LSQLGICSLE IRKPSPFDGG IYTCKAINAL GEASVDCRVD VKAPH