MBR1_CAEEL
ID MBR1_CAEEL Reviewed; 433 AA.
AC G5EGQ5;
DT 02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT 14-DEC-2011, sequence version 1.
DT 03-AUG-2022, entry version 68.
DE RecName: Full=Mblk-1-related factor 1 {ECO:0000303|PubMed:16139210};
GN Name=mbr-1 {ECO:0000312|WormBase:T01C1.2};
GN ORFNames=T01C1.2 {ECO:0000312|WormBase:T01C1.2};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|EMBL:BAE45265.1}
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
RP SPECIFICITY, DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
RC STRAIN=Bristol N2 {ECO:0000312|EMBL:BAE45265.1};
RX PubMed=16139210; DOI=10.1016/j.cub.2005.07.057;
RA Kage E., Hayashi Y., Takeuchi H., Hirotsu T., Kunitomo H., Inoue T.,
RA Arai H., Iino Y., Kubo T.;
RT "MBR-1, a novel helix-turn-helix transcription factor, is required for
RT pruning excessive neurites in Caenorhabditis elegans.";
RL Curr. Biol. 15:1554-1559(2005).
RN [2] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3] {ECO:0000305}
RP FUNCTION, TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
RX PubMed=19561603; DOI=10.1038/nn.2347;
RA Hayashi Y., Hirotsu T., Iwata R., Kage-Nakadai E., Kunitomo H.,
RA Ishihara T., Iino Y., Kubo T.;
RT "A trophic role for Wnt-Ror kinase signaling during developmental pruning
RT in Caenorhabditis elegans.";
RL Nat. Neurosci. 12:981-987(2009).
CC -!- FUNCTION: May act as transcription activator (By similarity). Plays a
CC role in neurogenesis by regulating neurite pruning between left and
CC right AIM neurons and left and right RIF neurons during larval
CC development (PubMed:16139210, PubMed:19561603). Regulates olfactory
CC plasticity (PubMed:19561603). {ECO:0000250|UniProtKB:Q95YM8,
CC ECO:0000269|PubMed:16139210, ECO:0000269|PubMed:19561603}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16139210}.
CC -!- TISSUE SPECIFICITY: Expressed in AIM, RIC, AIZ, ADF, ADL, ASK, AWA,
CC AUA, AIN, RIH (or RIR) and RIF head neurons and, in PVP, PVQ and DVA
CC (or DVC) tail neurons, some intestinal cells, somatic gonad and vulva.
CC {ECO:0000269|PubMed:16139210, ECO:0000269|PubMed:19561603}.
CC -!- DEVELOPMENTAL STAGE: Expressed at the comma stage and throughout larval
CC stages and in adult. {ECO:0000269|PubMed:16139210}.
CC -!- DISRUPTION PHENOTYPE: The left and right AIM neurons and the left and
CC right RIF neurons are connected by abnormal neurites in 40% and 80% of
CC adults respectively (PubMed:16139210, PubMed:19561603). Fails to reduce
CC chemotaxis to benzaldehyde after pre-exposure to benzaldehyde
CC (PubMed:19561603). In mbr-1 and cam-1 double mutants, normal neurite
CC pruning between left and right AIM neurons is restored
CC (PubMed:19561603). {ECO:0000269|PubMed:16139210,
CC ECO:0000269|PubMed:19561603}.
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DR EMBL; AB236333; BAE45265.1; -; mRNA.
DR EMBL; BX284606; CAA92010.2; -; Genomic_DNA.
DR PIR; T24277; T24277.
DR RefSeq; NP_509794.2; NM_077393.4.
DR AlphaFoldDB; G5EGQ5; -.
DR SMR; G5EGQ5; -.
DR STRING; 6239.T01C1.2; -.
DR EPD; G5EGQ5; -.
DR PaxDb; G5EGQ5; -.
DR EnsemblMetazoa; T01C1.2.1; T01C1.2.1; WBGene00011315.
DR GeneID; 187937; -.
DR KEGG; cel:CELE_T01C1.2; -.
DR CTD; 187937; -.
DR WormBase; T01C1.2; CE39173; WBGene00011315; mbr-1.
DR eggNOG; KOG4565; Eukaryota.
DR GeneTree; ENSGT00940000172051; -.
DR HOGENOM; CLU_036655_0_0_1; -.
DR InParanoid; G5EGQ5; -.
DR OMA; KWLESIW; -.
DR OrthoDB; 1087662at2759; -.
DR PhylomeDB; G5EGQ5; -.
DR PRO; PR:G5EGQ5; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00011315; Expressed in larva and 4 other tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR007889; HTH_Psq.
DR Pfam; PF05225; HTH_psq; 2.
DR SUPFAM; SSF46689; SSF46689; 2.
DR PROSITE; PS50960; HTH_PSQ; 2.
PE 2: Evidence at transcript level;
KW DNA-binding; Neurogenesis; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation.
FT CHAIN 1..433
FT /note="Mblk-1-related factor 1"
FT /evidence="ECO:0000305"
FT /id="PRO_0000437684"
FT DOMAIN 145..197
FT /note="HTH psq-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00320"
FT DOMAIN 334..386
FT /note="HTH psq-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00320"
FT DNA_BIND 173..193
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00320"
FT DNA_BIND 362..382
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00320"
FT REGION 235..278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 304..338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 393..433
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 235..266
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 304..321
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 322..338
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 398..433
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 433 AA; 48044 MW; F8A4ED5A6E43D01E CRC64;
MNSEPKPGLA MSSHFMGTDN QDQYKGTYAM NRLSIANLLN SPSSTLPTGN DFQNFGLERQ
INEGVLPQLL QNPWAINFWL QFQNAQLQPH LQYAALACSL VTENPLDLSN KTMNMLQKIG
VFNSVTKSED DESVAPEKPV DESLNKSNIL RRNYTVEDLT QAVEDIRQGK LGTRRASVVY
GIPRSTLRNK IYKLEAEGAI PSKVRRGKIA ARRAEAEQKR CVEATAAAAL LDAFGNQSDS
SSSSPHASMC PSSPDSTNSS LEGTGETPEM SDKKSCSPLD PKWLESIWQN LFKTQGNVVP
VDSANISNVD THTPTPISEK SQKMHGNEEW KRSRPKRGQY RKYDKNALDE AVRSVRRGEM
TVHRAGSFFG VPHSTLEYKV KERNLMRKKK DCLYSHDSST SEDGSQLVTS TISEKSDSSS
HTSTPIPFPI SLV
