MBRL_ARATH
ID MBRL_ARATH Reviewed; 623 AA.
AC Q8GWG6; Q9C953;
DT 23-MAY-2018, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Membralin-like protein At1g60995 {ECO:0000305};
GN OrderedLocusNames=At1g60995 {ECO:0000312|Araport:AT1G60995};
GN ORFNames=T7P1.14 {ECO:0000312|EMBL:AAG51636.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the membralin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG51636.1; Type=Erroneous gene model prediction; Note=The predicted gene has been split into 2 genes: At1g60995 and At1g61000.; Evidence={ECO:0000305};
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DR EMBL; AC018908; AAG51636.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE33764.1; -; Genomic_DNA.
DR EMBL; AK118859; BAC43446.1; -; mRNA.
DR RefSeq; NP_001077749.1; NM_001084280.2.
DR AlphaFoldDB; Q8GWG6; -.
DR STRING; 3702.AT1G60995.1; -.
DR PaxDb; Q8GWG6; -.
DR PRIDE; Q8GWG6; -.
DR ProteomicsDB; 238696; -.
DR EnsemblPlants; AT1G60995.1; AT1G60995.1; AT1G60995.
DR GeneID; 5007825; -.
DR Gramene; AT1G60995.1; AT1G60995.1; AT1G60995.
DR KEGG; ath:AT1G60995; -.
DR Araport; AT1G60995; -.
DR TAIR; locus:4010713572; AT1G60995.
DR eggNOG; KOG2092; Eukaryota.
DR eggNOG; KOG4438; Eukaryota.
DR HOGENOM; CLU_021947_0_0_1; -.
DR InParanoid; Q8GWG6; -.
DR OMA; KTFEPTY; -.
DR OrthoDB; 426985at2759; -.
DR PhylomeDB; Q8GWG6; -.
DR PRO; PR:Q8GWG6; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q8GWG6; baseline and differential.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:TAIR.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:1904294; P:positive regulation of ERAD pathway; IBA:GO_Central.
DR GO; GO:0106118; P:regulation of sterol biosynthetic process; IMP:TAIR.
DR GO; GO:0034976; P:response to endoplasmic reticulum stress; IBA:GO_Central.
DR InterPro; IPR019144; Membralin.
DR PANTHER; PTHR21650:SF4; PTHR21650:SF4; 1.
DR Pfam; PF09746; Membralin; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..623
FT /note="Membralin-like protein At1g60995"
FT /id="PRO_0000444105"
FT TRANSMEM 24..44
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 315..335
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 363..383
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 392..412
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 424..444
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 99..119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 506..567
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 602..623
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 506..533
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 541..567
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 623 AA; 71729 MW; 6382536013528916 CRC64;
MDPEQTFIRV QERFSQILTP RIRGFLEYTY LFVAITLFCI LVVMHANYVQ QPGCSSELTG
VELAEAELMQ IKITSAGLWS RNDESTAADV PRVVAATDSL EVSKTDQESS TSEENTDDTF
VKIDKEEPRS SFSVSAKENV RAAILRFLKK CYRRISFVLQ HTARILRGVR KIWNIIGIPL
NLDVPKLLHV LYMDKVNYYA VQWLESKTQE FEPTYLYTME KGYFLLPDEA KSRHNIRTAN
VSISARHPCF GNRWQQLLIN RVVGYDTIIM NSLQNSAGQG YLYNYQTREF YNLSYSQELP
DGSAHFGDYL VTKCGVLMMS LFVFFTTTMS VSFTLRETQT RMLKFTVQLQ HHAQHRLPTF
QLIFVHVIES LVFVPIMIGI LFFLFEFYDD QLLAFMVLVL VWLCELFTLI SVRTPISMKF
FPRFFLLYFL VFHIYFFSYA YGFSYLALMT TAAFMQHLIL YFWNRFEVPA LQRFLQSRQS
HLQQHPDFHI TSSTILASTL HITRLNRTTR NRTPSGPNHT TPNQNTETRS FTADGGGVGN
PAQYQEQQEE NEANTVPAEP NPQQAGAMSS FSSMLLWILG GASSEGLNSF LSMFRDVRDE
DEAQVFADTS PPQNPHHDPL SVD
