ID   MBTK_MYCPA              Reviewed;         221 AA.
AC   Q73ZP9;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-FEB-2007, sequence version 2.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Lysine N-acyltransferase MbtK;
DE            Short=N-acyltransferase MbtK;
DE            EC=2.3.1.-;
DE   AltName: Full=Mycobactin synthase protein K;
GN   Name=mbtK; OrderedLocusNames=MAP_1552;
OS   Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10)
OS   (Mycobacterium paratuberculosis).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium avium complex (MAC).
OX   NCBI_TaxID=262316;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-968 / K-10;
RX   PubMed=16116077; DOI=10.1073/pnas.0505662102;
RA   Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N.,
RA   Kanjilal S., Kapur V.;
RT   "The complete genome sequence of Mycobacterium avium subspecies
RT   paratuberculosis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005).
CC   -!- FUNCTION: Acyltransferase required for the direct transfer of
CC       medium- to long-chain fatty acyl moieties from a carrier protein (MbtL)
CC       on to the epsilon-amino group of lysine residue in the mycobactin core.
CC       {ECO:0000250}.
CC   -!- PATHWAY: Siderophore biosynthesis; mycobactin biosynthesis.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the lysine N-acyltransferase MbtK family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAS03869.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AE016958; AAS03869.1; ALT_FRAME; Genomic_DNA.
DR   AlphaFoldDB; Q73ZP9; -.
DR   SMR; Q73ZP9; -.
DR   STRING; 262316.MAP_1552; -.
DR   EnsemblBacteria; AAS03869; AAS03869; MAP_1552.
DR   KEGG; mpa:MAP_1552; -.
DR   eggNOG; COG1670; Bacteria.
DR   HOGENOM; CLU_039848_6_0_11; -.
DR   OMA; MALYALH; -.
DR   UniPathway; UPA00011; -.
DR   Proteomes; UP000000580; Chromosome.
DR   GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0019290; P:siderophore biosynthetic process; IEA:InterPro.
DR   InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR   InterPro; IPR019432; Acyltransferase_MbtK/IucB-like.
DR   SMART; SM01006; AlcB; 1.
DR   SUPFAM; SSF55729; SSF55729; 1.
PE   3: Inferred from homology;
KW   Acyltransferase; Reference proteome; Transferase.
FT   CHAIN           1..221
FT                   /note="Lysine N-acyltransferase MbtK"
FT                   /id="PRO_0000278302"
FT   REGION          1..34
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        179
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255"
FT   BINDING         141
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   221 AA;  24906 MW;  A51EEFF5A48A10E4 CRC64;
     MSDAPAESAP AQIDPAQTDP AEQPVQILPR ERSDIPDAVA RIPRPPVPHL DPPFALRVAR
     LGDADMVAEW MNRPHLAAAW EYDWPTPRWR RHLGAQLQGS YSLPLIGSMR GVDLAYLELY
     WAAKDLISRY YDAEPYDLGL HAAIADVKLV NRGLGPMLLP RIVASVFATE PRCRRVMFDP
     DHRNTTARRL CEYAGCRFLG EHDTTNRRMA LYALDAPTTD R