ID   MBTK_MYCTO              Reviewed;         210 AA.
AC   P9WK14; L0T804; P64819; Q11017;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 35.
DE   RecName: Full=Lysine N-acyltransferase MbtK;
DE            Short=N-acyltransferase MbtK;
DE            EC=2.3.1.-;
DE   AltName: Full=Mycobactin synthase protein K;
GN   Name=mbtK; OrderedLocusNames=MT1389;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Acyltransferase required for the direct transfer of
CC       medium- to long-chain fatty acyl moieties from a carrier protein (MbtL)
CC       on to the epsilon-amino group of lysine residue in the mycobactin core.
CC       {ECO:0000250}.
CC   -!- PATHWAY: Siderophore biosynthesis; mycobactin biosynthesis.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the lysine N-acyltransferase MbtK family.
CC       {ECO:0000305}.
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DR   EMBL; AE000516; AAK45653.1; -; Genomic_DNA.
DR   PIR; B70740; B70740.
DR   RefSeq; WP_003406956.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WK14; -.
DR   SMR; P9WK14; -.
DR   EnsemblBacteria; AAK45653; AAK45653; MT1389.
DR   GeneID; 45425325; -.
DR   KEGG; mtc:MT1389; -.
DR   PATRIC; fig|83331.31.peg.1497; -.
DR   HOGENOM; CLU_039848_4_0_11; -.
DR   UniPathway; UPA00011; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0019290; P:siderophore biosynthetic process; IEA:InterPro.
DR   InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR   InterPro; IPR019432; Acyltransferase_MbtK/IucB-like.
DR   SMART; SM01006; AlcB; 1.
DR   SUPFAM; SSF55729; SSF55729; 1.
PE   3: Inferred from homology;
KW   Acyltransferase; Transferase.
FT   CHAIN           1..210
FT                   /note="Lysine N-acyltransferase MbtK"
FT                   /id="PRO_0000427733"
FT   ACT_SITE        168
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255"
FT   BINDING         130
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   210 AA;  23799 MW;  2ADDBB5D0BE81561 CRC64;
     MTKPTSAGQA DDALVRLARE RFDLPDQVRR LARPPVPSLE PPYGLRVAQL TDAEMLAEWM
     NRPHLAAAWE YDWPASRWRQ HLNAQLEGTY SLPLIGSWHG TDGGYLELYW AAKDLISHYY
     DADPYDLGLH AAIADLSKVN RGFGPLLLPR IVASVFANEP RCRRIMFDPD HRNTATRRLC
     EWAGCKFLGE HDTTNRRMAL YALEAPTTAA