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MBTN_MYCBO
ID   MBTN_MYCBO              Reviewed;         386 AA.
AC   P63432; A0A1R3XZ20; Q11016; X2BHU7;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Acyl-[acyl-carrier-protein] dehydrogenase MbtN;
DE            Short=Acyl-ACP dehydrogenase MbtN;
DE            EC=1.3.99.-;
DE   AltName: Full=Mycobactin synthase protein N;
GN   Name=mbtN; Synonyms=fadE14; OrderedLocusNames=BQ2027_MB1381;
OS   Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=233413;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA   Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA   Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA   Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA   Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT   "The complete genome sequence of Mycobacterium bovis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA   Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA   Robbe-Austerman S., Gordon S.V.;
RT   "Updated reference genome sequence and annotation of Mycobacterium bovis
RT   AF2122/97.";
RL   Genome Announc. 5:E00157-E00157(2017).
CC   -!- FUNCTION: Catalyzes the dehydrogenation at the alpha-beta position of
CC       ACP-bound acyl chains. This results in the introduction of a double
CC       bond in the lipidic chain, which is further transferred to the epsilon-
CC       amino group of lysine residue in the mycobactin core by MbtK (By
CC       similarity). {ECO:0000250}.
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
CC   -!- PATHWAY: Siderophore biosynthesis; mycobactin biosynthesis.
CC   -!- SIMILARITY: Belongs to the acyl-CoA dehydrogenase family.
CC       {ECO:0000305}.
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DR   EMBL; LT708304; SIT99984.1; -; Genomic_DNA.
DR   RefSeq; NP_855035.1; NC_002945.3.
DR   RefSeq; WP_003406953.1; NC_002945.4.
DR   AlphaFoldDB; P63432; -.
DR   SMR; P63432; -.
DR   EnsemblBacteria; SIT99984; SIT99984; BQ2027_MB1381.
DR   GeneID; 45425324; -.
DR   PATRIC; fig|233413.5.peg.1513; -.
DR   OMA; MMTRRQF; -.
DR   UniPathway; UPA00011; -.
DR   Proteomes; UP000001419; Chromosome.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR   GO; GO:0016627; F:oxidoreductase activity, acting on the CH-CH group of donors; IEA:InterPro.
DR   Gene3D; 1.10.540.10; -; 1.
DR   Gene3D; 2.40.110.10; -; 1.
DR   InterPro; IPR006091; Acyl-CoA_Oxase/DH_mid-dom.
DR   InterPro; IPR046373; Acyl-CoA_Oxase/DH_mid-dom_sf.
DR   InterPro; IPR036250; AcylCo_DH-like_C.
DR   InterPro; IPR009075; AcylCo_DH/oxidase_C.
DR   InterPro; IPR037069; AcylCoA_DH/ox_N_sf.
DR   InterPro; IPR009100; AcylCoA_DH/oxidase_NM_dom.
DR   Pfam; PF00441; Acyl-CoA_dh_1; 1.
DR   Pfam; PF02770; Acyl-CoA_dh_M; 1.
DR   SUPFAM; SSF47203; SSF47203; 1.
DR   SUPFAM; SSF56645; SSF56645; 1.
PE   3: Inferred from homology;
KW   FAD; Flavoprotein; Oxidoreductase.
FT   CHAIN           1..386
FT                   /note="Acyl-[acyl-carrier-protein] dehydrogenase MbtN"
FT                   /id="PRO_0000000539"
SQ   SEQUENCE   386 AA;  41180 MW;  60A2765380F89EFB CRC64;
     MTAGSDLDDF RGLLAKAFDE RVVAWTAEAE AQERFPRQLI EHLGVCGVFD AKWATDARPD
     VGKLVELAFA LGQLASAGIG VGVSLHDSAI AILRRFGKSD YLRDICDQAI RGAAVLCIGA
     SEESGGSDLQ IVETEIRSRD GGFEVRGVKK FVSLSPIADH IMVVARSVDH DPTSRHGNVA
     VVAVPAAQVS VQTPYRKVGA GPLDTAAVCI DTWVPADALV ARAGTGLAAI SWGLAHERMS
     IAGQIAASCQ RAIGITLARM MSRRQFGQTL FEHQALRLRM ADLQARVDLL RYALHGIAEQ
     GRLELRTAAA VKVTAARLGE EVISECMHIF GGAGYLVDET TLGKWWRDMK LARVGGGTDE
     VLWELVAAGM TPDHDGYAAV VGASKA
 
 
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