MBTR1_CAEEL
ID MBTR1_CAEEL Reviewed; 564 AA.
AC A0SQM0; A9D1A1;
DT 16-MAY-2012, integrated into UniProtKB/Swiss-Prot.
DT 09-JAN-2007, sequence version 1.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=Malignant brain tumor repeat protein 1;
GN Name=mbtr-1; ORFNames=Y48G1A.6;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), AND DISRUPTION PHENOTYPE.
RC STRAIN=Bristol N2;
RX PubMed=17409073; DOI=10.1534/genetics.106.069633;
RA Harrison M.M., Lu X., Horvitz H.R.;
RT "LIN-61, one of two Caenorhabditis elegans malignant-brain-tumor-repeat-
RT containing proteins, acts with the DRM and NuRD-like protein complexes in
RT vulval development but not in certain other biological processes.";
RL Genetics 176:255-271(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), AND INTERACTION WITH HISTONE H3.
RC STRAIN=Bristol N2;
RX PubMed=21437264; DOI=10.1371/journal.pgen.1002017;
RA Koester-Eiserfunke N., Fischle W.;
RT "H3K9me2/3 binding of the MBT domain protein LIN-61 is essential for
RT Caenorhabditis elegans vulva development.";
RL PLoS Genet. 7:E1002017-E1002017(2011).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SUBUNIT: Interacts with histone H3 that is trimethylated at 'Lys-9'
CC (H3K9me3). {ECO:0000269|PubMed:21437264}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a;
CC IsoId=A0SQM0-1; Sequence=Displayed;
CC Name=b;
CC IsoId=A0SQM0-2; Sequence=VSP_043613;
CC -!- DISRUPTION PHENOTYPE: No visible phenotype.
CC {ECO:0000269|PubMed:17409073}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DQ904352; ABI78934.1; -; mRNA.
DR EMBL; FO080938; CCD67944.1; -; Genomic_DNA.
DR EMBL; FO080938; CCD67945.1; -; Genomic_DNA.
DR RefSeq; NP_001122542.1; NM_001129070.1. [A0SQM0-1]
DR RefSeq; NP_001122543.1; NM_001129071.2. [A0SQM0-2]
DR AlphaFoldDB; A0SQM0; -.
DR SMR; A0SQM0; -.
DR BioGRID; 37126; 1.
DR IntAct; A0SQM0; 1.
DR STRING; 6239.Y48G1A.6a; -.
DR PaxDb; A0SQM0; -.
DR PRIDE; A0SQM0; -.
DR EnsemblMetazoa; Y48G1A.6a.1; Y48G1A.6a.1; WBGene00021661. [A0SQM0-1]
DR EnsemblMetazoa; Y48G1A.6b.1; Y48G1A.6b.1; WBGene00021661. [A0SQM0-2]
DR GeneID; 171624; -.
DR KEGG; cel:CELE_Y48G1A.6; -.
DR UCSC; Y48G1A.6b; c. elegans.
DR CTD; 171624; -.
DR WormBase; Y48G1A.6a; CE41949; WBGene00021661; mbtr-1. [A0SQM0-1]
DR WormBase; Y48G1A.6b; CE41950; WBGene00021661; mbtr-1. [A0SQM0-2]
DR eggNOG; KOG3766; Eukaryota.
DR GeneTree; ENSGT00940000169237; -.
DR InParanoid; A0SQM0; -.
DR OrthoDB; 1621899at2759; -.
DR PhylomeDB; A0SQM0; -.
DR PRO; PR:A0SQM0; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00021661; Expressed in adult organism and 3 other tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IBA:GO_Central.
DR InterPro; IPR004092; Mbt.
DR Pfam; PF02820; MBT; 3.
DR SMART; SM00561; MBT; 4.
DR PROSITE; PS51079; MBT; 4.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome; Repeat.
FT CHAIN 1..564
FT /note="Malignant brain tumor repeat protein 1"
FT /id="PRO_0000417370"
FT REPEAT 64..176
FT /note="MBT 1"
FT REPEAT 205..327
FT /note="MBT 2"
FT REPEAT 331..442
FT /note="MBT 3"
FT REPEAT 450..549
FT /note="MBT 4"
FT VAR_SEQ 2..20
FT /note="EKSSSNFIQNGKRDHGGKL -> NFSNKK (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_043613"
SQ SEQUENCE 564 AA; 65751 MW; 427B07DB33BB2BFD CRC64;
MEKSSSNFIQ NGKRDHGGKL RQYNYKLEEA EYRYFTEERL FYRRRNPVEK IAQRIPKPQI
EGTFTWSDEL RCNYDGNTQF LPVEALEGCL PLEKLNQHLK PGFRLEVVVR PSLDPSITTK
SPEIRWFGEV TAVCGFYVAI KFVGELNRRP CWFHMLSEDI FDIGSGLKQD PAMKWLQYRP
LSLLKPMQCP KFWRRGSTPA PPVPRPTEEI LDEFQAELHE NRISEPKIFD QLRHLAHRPS
RFRLNQRVEL LNYLEPTEIR VARILRILGR RLMVMVTAQD YPEDLPSVEA KDRQVQHENV
EFWVDESSFF LFPVGFAMIN GLRTKATEGY LEHSRRIAEG SGSYHKDDVT FEQLFAGKPD
ISAEKLNLLK VGQKFELLDP LSDLRQSFCV ATIRKICKTP GFLIISPDET ESDDESFPIH
IDNHFMHPVG YAEKFGIKLD RLAGTEPGKF KWEGYLKEKQ AEKIPDEMLR PLPSKERRHM
FEFGRVLEAV GQNETYWISP ASVEEVHGRT VLIEFQGWDS EFSELYDMDS HDLLPAGWCE
FFNFKLRHPV LPVNDPNAEN GEYD
