ID   MC005_MCV1              Reviewed;          85 AA.
AC   Q98176;
DT   20-DEC-2017, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   23-FEB-2022, entry version 42.
DE   RecName: Full=Protein MC005;
GN   Name=MC005L;
OS   Molluscum contagiosum virus subtype 1 (MOCV) (MCVI).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Molluscipoxvirus.
OX   NCBI_TaxID=10280;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=8670425; DOI=10.1126/science.273.5276.813;
RA   Senkevich T.G., Bugert J.J., Sisler J.R., Koonin E.V., Darai G., Moss B.;
RT   "Genome sequence of a human tumorigenic poxvirus: prediction of specific
RT   host response-evasion genes.";
RL   Science 273:813-816(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Lopez-Bueno A., Parras-Molto M., Lopez-Barrantes O., Belda S., Alejo A.;
RT   "Recombination events and variability among full-length genomes of co-
RT   circulating molluscum contagiosum virus subtypes 1 and 2.";
RL   J. Gen. Virol. 0:0-0(2017).
RN   [3]
RP   FUNCTION, INTERACTION WITH HOST IKBKG, AND SUBCELLULAR LOCATION.
RX   PubMed=28490597; DOI=10.1128/jvi.00545-17;
RA   Brady G., Haas D.A., Farrell P.J., Pichlmair A., Bowie A.G.;
RT   "Molluscum contagiosum virus protein MC005 inhibits NF-kappaB activation by
RT   targeting NEMO-regulated IkappaB kinase activation.";
RL   J. Virol. 91:0-0(2017).
CC   -!- FUNCTION: Plays a role in the inhibition of the host NF-kappa-B pathway
CC       by preventing ubiquitin binding-dependent regulation of host IKBKB
CC       activation by IKBKG/NEMO. {ECO:0000269|PubMed:28490597}.
CC   -!- SUBUNIT: Interacts with host IKBKG; this interaction prevents NF-kappa-
CC       B activation. {ECO:0000269|PubMed:28490597}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000269|PubMed:28490597}.
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DR   EMBL; U60315; AAC55133.1; -; Genomic_DNA.
DR   EMBL; KY040275; AQY16743.1; -; Genomic_DNA.
DR   EMBL; KY040277; AQY17103.1; -; Genomic_DNA.
DR   PIR; T30607; T30607.
DR   RefSeq; NP_043956.1; NC_001731.1.
DR   GeneID; 1487026; -.
DR   KEGG; vg:1487026; -.
DR   Proteomes; UP000000869; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0039644; P:suppression by virus of host NF-kappaB cascade; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Host cytoplasm; Host-virus interaction;
KW   Inhibition of host NF-kappa-B by virus; Reference proteome.
FT   CHAIN           1..85
FT                   /note="Protein MC005"
FT                   /id="PRO_0000442576"
SQ   SEQUENCE   85 AA;  8900 MW;  C03CAA881717F6E4 CRC64;
     MCLVAPMQCG CASCVRILDA LLSAMEALVQ MRLLSEEEKT SCASQFLELA IFAVENCRGG
     RQALLQARGE PASLGEVAGK GPAAD